SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1scj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 GLY A 229
HIS A 226
VAL A  81
ALA A 228
ASN A 123
 None
 1.16A 1eqbD-1scjA:
2.9		 1eqbD-1scjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 7 LEU A 250
GLY A   7
ILE A   8
VAL A 227
ILE A 268
 None
 1.49A 2aojB-1scjA:
undetectable		 2aojB-1scjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 VAL A 165
GLY A 166
GLY A 127
THR A 224
ALA A 176
 None
None
None
None
CA  A 382 (-3.8A)
 1.06A 2egvA-1scjA:
2.2		 2egvA-1scjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 VAL A 165
GLY A 166
GLY A 127
THR A 224
ALA A 176
 None
None
None
None
CA  A 382 (-3.8A)
 1.02A 2egvB-1scjA:
2.9		 2egvB-1scjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 SER A 125
ILE A  11
ALA A 150
ASN A 123
VAL A 180
 None
 1.32A 2gl0D-1scjA:
undetectable
2gl0E-1scjA:
undetectable		 2gl0D-1scjA:
18.28
2gl0E-1scjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		4 / 8 GLY A 202
GLY A   7
ILE A   8
THR A  71
 None
 0.64A 3d41A-1scjA:
undetectable		 3d41A-1scjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 ILE A 234
ALA A 274
GLN A 271
ILE A 268
VAL A 148
 None
 1.10A 3dzuA-1scjA:
undetectable		 3dzuA-1scjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		4 / 5 ASP A  32
ILE A  72
VAL A 121
THR A 174
 None
None
None
CA  A 382 (-4.1A)
 1.18A 3eigA-1scjA:
undetectable		 3eigA-1scjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		3 / 3 TYR B 377
TYR A 104
GLY A 166
 None
 0.55A 3eteB-1scjB:
undetectable
3eteD-1scjB:
undetectable
3eteF-1scjB:
undetectable		 3eteB-1scjB:
9.17
3eteD-1scjB:
9.17
3eteF-1scjB:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 10 ALA A 150
VAL A 121
ALA A 273
ILE A 234
LEU A 235
 None
 1.21A 3fl9A-1scjA:
undetectable		 3fl9A-1scjA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 ALA A  73
GLY A  83
LEU A  42
SER A  87
GLY A  23
 None
 1.10A 3g2oB-1scjA:
2.6		 3g2oB-1scjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 GLY A  70
GLY A  83
ILE A  35
ASP A  41
LEU A  42
 None
None
None
CA  A 381 (-2.4A)
None
 1.02A 3ihtA-1scjA:
2.7		 3ihtA-1scjA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 11 TYR A  21
THR A  22
ALA A  15
GLN A  19
THR A 253
 None
 1.34A 3qelA-1scjA:
4.4
3qelB-1scjA:
6.2		 3qelA-1scjA:
23.04
3qelB-1scjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 10 ALA A 176
LEU A 250
ALA A 231
VAL A  84
THR A  71
 CA  A 382 (-3.8A)
None
None
None
None
 1.31A 3r9cA-1scjA:
undetectable		 3r9cA-1scjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1scj SUBTILISIN E
SUBTILISIN E
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 12 ALA A 176
GLY A 154
ALA B 374
PRO A 168
LEU A 135
 CA  A 382 (-3.8A)
None
None
None
None
 1.33A 3tm4A-1scjA:
2.5		 3tm4A-1scjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1scj SUBTILISIN E
SUBTILISIN E
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 12 ALA A 176
GLY A 154
ALA B 374
PRO A 168
LEU A 135
 CA  A 382 (-3.8A)
None
None
None
None
 1.32A 3tm4B-1scjA:
undetectable		 3tm4B-1scjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		4 / 6 MET A 119
ILE A 268
ILE A  11
VAL A 270
 None
 1.00A 4olmA-1scjA:
0.0		 4olmA-1scjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 8 LEU A 233
VAL A  84
ILE A 268
ALA A 273
LEU A 250
 None
 1.32A 4qrcA-1scjA:
undetectable		 4qrcA-1scjA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 TYR A  21
THR A  22
ALA A  15
GLN A  19
THR A 253
 None
 1.38A 5ewjC-1scjA:
6.5
5ewjD-1scjA:
6.2		 5ewjC-1scjA:
23.04
5ewjD-1scjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		4 / 5 GLY A 154
SER A 190
ARG A 186
GLY A 157
 None
 1.12A 5kprA-1scjA:
1.8		 5kprA-1scjA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1scj SUBTILISIN E
(Bacillus
subtilis) 		5 / 12 VAL B 344
VAL A 138
GLY A 102
THR A 130
GLY A 131
 None
 1.15A 6brdC-1scjB:
undetectable		 6brdC-1scjB:
19.05