SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  69
ASP A  72
ASP A  65
 None
 0.76A 1sqfA-1sd5A:
3.0		 1sqfA-1sd5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  61
ILE A  25
ILE A 118
VAL A  16
ILE A  63
 None
IOD  A 414 ( 4.4A)
None
None
None
 1.01A 2avoA-1sd5A:
undetectable		 2avoA-1sd5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  91
LEU A  61
PHE A 116
 None
None
IOD  A 414 (-3.9A)
 0.56A 2pgrA-1sd5A:
undetectable		 2pgrA-1sd5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  61
ILE A  25
ILE A 118
VAL A  16
ILE A  63
 None
IOD  A 414 ( 4.4A)
None
None
None
 1.17A 3d1yB-1sd5A:
undetectable		 3d1yB-1sd5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		6 / 11 ALA A  77
ALA A  76
VAL A  90
ALA A 108
GLY A 107
ALA A 103
 None
None
None
IOD  A 407 ( 4.3A)
None
None
 1.21A 3mg0K-1sd5A:
undetectable
3mg0L-1sd5A:
undetectable		 3mg0K-1sd5A:
21.98
3mg0L-1sd5A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		6 / 12 ALA A  77
ALA A  76
VAL A  90
ALA A 108
GLY A 107
ALA A 103
 None
None
None
IOD  A 407 ( 4.3A)
None
None
 1.22A 3mg0Y-1sd5A:
undetectable
3mg0Z-1sd5A:
undetectable		 3mg0Y-1sd5A:
21.98
3mg0Z-1sd5A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 170
LEU A 127
ARG A 131
SER A 130
ALA A 192
 None
 1.46A 4mx0A-1sd5A:
undetectable		 4mx0A-1sd5A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		5 / 12 SER A  95
THR A  92
TYR A 111
GLU A  20
ASP A  65
 None
 1.47A 4qb9E-1sd5A:
0.0		 4qb9E-1sd5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 170
ARG A 131
VAL A 195
LEU A 196
GLY A 160
 None
None
IOD  A 415 ( 4.0A)
None
None
 1.17A 5vooE-1sd5A:
2.8		 5vooE-1sd5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1sd5 PUTATIVE
ANTITERMINATOR
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  65
GLN A  96
VAL A  66
GLU A  20
 None
 1.19A 6djzB-1sd5A:
undetectable		 6djzB-1sd5A:
24.18