SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 ILE A 141
GLY A 168
VAL A 166
ALA A 180
HIS A 200
 None
 1.19A 1kiaB-1sdeA:
undetectable		 1kiaB-1sdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 ILE A 141
GLY A 168
VAL A 166
ALA A 180
HIS A 200
 None
 1.20A 1nbhA-1sdeA:
undetectable		 1nbhA-1sdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 ILE A 141
GLY A 168
VAL A 166
ALA A 180
HIS A 200
 None
 1.18A 1nbhC-1sdeA:
undetectable		 1nbhC-1sdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 ILE A 141
GLY A 168
VAL A 166
ALA A 180
HIS A 200
 None
 1.19A 1nbhD-1sdeA:
undetectable		 1nbhD-1sdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 9 LEU A  72
ILE A 187
PHE A  67
GLY A 283
PHE A 250
 None
 1.39A 1td7A-1sdeA:
undetectable		 1td7A-1sdeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 9 LEU A  73
ILE A 187
PHE A  67
GLY A 283
PHE A 250
 None
 1.08A 1td7A-1sdeA:
undetectable		 1td7A-1sdeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		3 / 3 ASP A 195
ASP A 248
ASP A  56
 None
 0.59A 2igtA-1sdeA:
undetectable		 2igtA-1sdeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		3 / 3 ASP A 195
ASP A 248
ASP A  56
 None
 0.56A 2igtB-1sdeA:
undetectable		 2igtB-1sdeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 6 SER A 158
SER A 110
LEU A 112
GLY A 111
 None
 0.99A 2j2pA-1sdeA:
0.0
2j2pC-1sdeA:
undetectable		 2j2pA-1sdeA:
22.57
2j2pC-1sdeA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 6 SER A 158
SER A 110
LEU A 112
GLY A 111
 None
 0.99A 2j2pD-1sdeA:
undetectable
2j2pF-1sdeA:
undetectable		 2j2pD-1sdeA:
22.57
2j2pF-1sdeA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 10 PHE A 343
ASP A  32
ASN A  33
ASP A 248
VAL A 319
 None
 1.35A 3ay0A-1sdeA:
undetectable		 3ay0A-1sdeA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 MET A 119
THR A 123
VAL A 124
GLN A 229
THR A 230
 None
 1.19A 3em0A-1sdeA:
0.0		 3em0A-1sdeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 ARG A 287
ASP A  32
VAL A  30
GLY A 345
VAL A 319
 None
 1.11A 3gguA-1sdeA:
undetectable		 3gguA-1sdeA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 5 GLY A  49
ASP A  45
ARG A  46
MET A 335
 None
 1.38A 3qx3A-1sdeA:
undetectable		 3qx3A-1sdeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 5 GLY A  49
ASP A  45
ARG A  46
MET A 335
 None
 1.30A 3qx3B-1sdeA:
0.0		 3qx3B-1sdeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 4 GLY A  61
GLY A 300
THR A 307
LEU A 247
 2PB  A 400 (-3.6A)
2PB  A 400 (-3.4A)
None
None
 0.80A 3si7C-1sdeA:
undetectable
3si7D-1sdeA:
undetectable		 3si7C-1sdeA:
22.04
3si7D-1sdeA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		3 / 3 LEU A  83
LEU A  91
ASN A 163
 None
 0.77A 4otwA-1sdeA:
undetectable		 4otwA-1sdeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		3 / 3 ASN A 161
SER A  62
ARG A 285
 2PB  A 400 ( 3.6A)
2PB  A 400 (-1.6A)
2PB  A 400 (-3.9A)
 0.91A 5b2qA-1sdeA:
undetectable		 5b2qA-1sdeA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		3 / 3 SER A  86
LEU A 282
MET A 106
 None
 0.61A 5ikrB-1sdeA:
undetectable		 5ikrB-1sdeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		3 / 3 TYR A 159
TYR A 198
SER A  68
 2PB  A 400 (-4.2A)
None
None
 1.00A 5iktB-1sdeA:
undetectable		 5iktB-1sdeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		3 / 3 THR A 272
SER A 107
ASP A  84
 None
 0.80A 5kvaA-1sdeA:
undetectable		 5kvaA-1sdeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 GLY A 283
TYR A 157
THR A 272
VAL A 274
LEU A  83
 None
 1.24A 5nz0A-1sdeA:
0.0		 5nz0A-1sdeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 5 GLY A  49
ASP A  45
ARG A  46
MET A 335
 None
 1.39A 5zrfB-1sdeA:
undetectable		 5zrfB-1sdeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 4 GLY A  49
ASP A  45
ARG A  46
MET A 335
 None
 1.39A 5zrfA-1sdeA:
undetectable		 5zrfA-1sdeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 5 SER A 107
VAL A 105
ASN A 163
PRO A 153
 None
 1.44A 6fi4A-1sdeA:
undetectable
6fi4B-1sdeA:
undetectable		 6fi4A-1sdeA:
20.97
6fi4B-1sdeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 5 ASN A 275
TYR A 296
GLY A 297
ASP A 288
 None
 1.30A 6gh9A-1sdeA:
undetectable		 6gh9A-1sdeA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		4 / 8 VAL A  87
ASN A  88
GLN A 138
PRO A  92
 None
 1.08A 6hzpA-1sdeA:
undetectable		 6hzpA-1sdeA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Streptomyces
sp.
R61) 		5 / 12 GLY A  25
LEU A  19
GLY A  22
ASN A 211
VAL A 331
 None
None
GOL  A 500 ( 4.6A)
None
None
 1.03A 6mhtA-1sdeA:
undetectable		 6mhtA-1sdeA:
21.34