SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		3 / 3 TYR A 162
TYR A 254
GLU A 160
 None
 0.93A 3pfgA-1sefA:
undetectable		 3pfgA-1sefA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 5 ALA A 240
GLU A 163
GLU A 199
ALA A 196
 None
 1.08A 3r9tC-1sefA:
undetectable		 3r9tC-1sefA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 8 THR A 103
ARG A  96
LEU A 122
MET A 120
 None
 1.15A 3wipG-1sefA:
0.7
3wipH-1sefA:
0.8		 3wipG-1sefA:
22.60
3wipH-1sefA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 9 ASP A  82
ILE A  84
GLY A  81
THR A  86
GLN A  75
 None
 1.42A 4acaB-1sefA:
undetectable
4acaC-1sefA:
undetectable		 4acaB-1sefA:
17.96
4acaC-1sefA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 9 GLY A  59
PHE A 232
ASP A  64
TYR A  65
SER A  51
 None
 1.50A 4gcpB-1sefA:
0.0		 4gcpB-1sefA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 8 VAL A 168
TYR A 162
GLY A 164
ALA A 193
 None
 0.85A 4m48A-1sefA:
undetectable		 4m48A-1sefA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 PRO A 238
ALA A  30
ALA A  60
GLY A  59
LEU A  58
 None
 0.96A 4oaeA-1sefA:
undetectable		 4oaeA-1sefA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 7 GLU A 199
TYR A 252
LEU A 250
TYR A 162
 None
 1.07A 4twdF-1sefA:
0.0
4twdJ-1sefA:
undetectable		 4twdF-1sefA:
21.58
4twdJ-1sefA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 5 ASP A 257
ASP A  64
PHE A 232
GLY A 206
 None
 1.24A 4xp6A-1sefA:
undetectable		 4xp6A-1sefA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASP A  35
HIS A  34
SER A  51
HIS A  70
ASP A 129
 None
 1.45A 5ef8A-1sefA:
undetectable		 5ef8A-1sefA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 7 VAL A  48
ILE A  50
VAL A 132
ALA A  67
 None
 0.51A 5ospA-1sefA:
undetectable		 5ospA-1sefA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1sef CONSERVED
HYPOTHETICAL PROTEIN
(Enterococcus
faecalis) 		4 / 7 VAL A  48
ILE A  50
VAL A 132
ALA A  67
 None
 0.52A 5osrA-1sefA:
undetectable		 5osrA-1sefA:
21.41