SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ser'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		3 / 3 ALA A 389
VAL A 137
TRP A 146
 None
 0.87A 1nt6A-1serA:
undetectable		 1nt6A-1serA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		3 / 3 ALA A 389
VAL A 137
TRP A 146
 None
 0.87A 1nt6B-1serA:
undetectable		 1nt6B-1serA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 7 THR A 380
GLU A 227
SER A 350
VAL A 318
 None
 1.18A 1tv8A-1serA:
undetectable		 1tv8A-1serA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 10 ALA A 360
LEU A 244
LEU A 246
SER A 235
ARG A 363
 None
 1.30A 2ceoB-1serA:
0.0		 2ceoB-1serA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 9 ILE A 305
ILE A 333
GLU A 303
ALA A 302
THR A 346
 None
 1.31A 2dtjA-1serA:
undetectable
2dtjB-1serA:
undetectable		 2dtjA-1serA:
17.62
2dtjB-1serA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 6 ARG A 314
GLU A 317
PRO A 110
ALA A 116
 None
 1.17A 2ejfB-1serA:
4.6		 2ejfB-1serA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 8 THR A 380
GLU A 227
SER A 350
VAL A 318
 None
 1.16A 2fb2A-1serA:
undetectable		 2fb2A-1serA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 7 THR A 380
GLU A 227
SER A 350
VAL A 318
 None
 1.22A 2fb2B-1serA:
undetectable		 2fb2B-1serA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 LEU A 417
ILE A 387
PRO A 405
VAL A 404
VAL A 402
 None
 0.74A 2nnkB-1serA:
undetectable		 2nnkB-1serA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 MET A 140
LEU A 161
LEU A 388
ILE A 150
VAL A 272
 None
 1.26A 2pnjB-1serA:
undetectable		 2pnjB-1serA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 MET A 140
LEU A 161
LEU A 388
ILE A 150
VAL A 272
 None
 1.20A 3aqiB-1serA:
undetectable		 3aqiB-1serA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 11 LYS A 277
TYR A 281
TYR A 248
LEU A 190
GLU A 227
 None
 1.28A 3m8pA-1serA:
1.8
3m8pB-1serA:
1.2		 3m8pA-1serA:
20.45
3m8pB-1serA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 9 LEU A 172
LEU A 382
THR A 346
HIS A 395
LEU A 306
 None
 1.36A 3q1eB-1serA:
0.0
3q1eD-1serA:
0.0		 3q1eB-1serA:
13.29
3q1eD-1serA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 8 GLU A 119
GLU A 334
TYR A 313
GLY A 125
ARG A 122
 None
 1.47A 4fgzA-1serA:
undetectable
4fgzB-1serA:
undetectable		 4fgzA-1serA:
18.78
4fgzB-1serA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 ILE A 333
LEU A 417
LEU A 165
LEU A 311
HIS A 395
 None
 1.17A 4j03A-1serA:
undetectable		 4j03A-1serA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 8 ARG A 271
ASP A 332
GLU A 114
ARG A 386
 None
 1.37A 4kr4C-1serA:
undetectable		 4kr4C-1serA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 ILE A 387
ALA A 302
LEU A 306
LEU A 309
LEU A 311
 None
 0.96A 4o1zA-1serA:
undetectable		 4o1zA-1serA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 ILE A 409
THR A 384
LEU A 408
LEU A 165
LEU A 417
 None
 1.40A 4qynB-1serA:
0.0		 4qynB-1serA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 11 TYR A 248
TYR A 281
HIS A 234
LEU A 239
LEU A 244
 None
 1.49A 4yvpA-1serA:
undetectable		 4yvpA-1serA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 ASN A 231
VAL A 228
GLY A 250
TYR A 281
MET A 180
 None
 1.42A 5fhrA-1serA:
undetectable		 5fhrA-1serA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 5 LEU A 408
LEU A 417
LEU A 388
HIS A 395
 None
 1.03A 5gtrA-1serA:
undetectable		 5gtrA-1serA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		3 / 3 LEU A   7
LEU A  98
ARG A 363
 None
 0.60A 5hnzB-1serA:
undetectable		 5hnzB-1serA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 8 ALA A 171
LEU A 165
LEU A 417
LEU A 388
 None
 0.63A 5jqbA-1serA:
undetectable
5jqbB-1serA:
undetectable		 5jqbA-1serA:
20.65
5jqbB-1serA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		3 / 3 LEU A 388
ALA A 389
LEU A 165
 None
 0.47A 5uunB-1serA:
undetectable		 5uunB-1serA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		5 / 12 GLN A 356
GLY A 203
VAL A 212
LYS A 327
GLY A 326
 None
 1.08A 6c2mD-1serA:
undetectable		 6c2mD-1serA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 5 ARG A 195
ALA A 194
TYR A 221
ILE A 215
 None
 1.33A 6g9bA-1serA:
undetectable
6g9bB-1serA:
0.0		 6g9bA-1serA:
10.98
6g9bB-1serA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 4 ASP A  26
ILE A  18
PRO A 102
LEU A  25
 None
 1.38A 6mkeB-1serA:
undetectable		 6mkeB-1serA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))
(Thermus
thermophilus) 		4 / 4 ASP A  26
ILE A  18
PRO A 102
LEU A  25
 None
 1.34A 6mkeA-1serA:
0.0		 6mkeA-1serA:
11.20