SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 8 THR A 246
GLY A  49
GLY A 241
ARG A  53
None
0.54A 1d0vA-1sezA:
undetectable
1d0vA-1sezA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 8 THR A 246
GLY A  49
GLY A 241
ARG A  53
None
0.51A 1jhaA-1sezA:
undetectable
1jhaA-1sezA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 8 THR A 246
GLY A  49
GLY A 241
ARG A  53
None
0.52A 1jhqA-1sezA:
undetectable
1jhqA-1sezA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 8 THR A 246
GLY A  49
GLY A 241
ARG A  53
None
0.57A 1jhvA-1sezA:
undetectable
1jhvA-1sezA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 10 LEU A 473
ALA A 438
GLY A 394
GLY A 395
THR A 176
None
FAD  A 600 (-3.7A)
None
None
None
0.98A 1k6cA-1sezA:
undetectable
1k6cA-1sezA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
3 / 3 PHE A 373
LEU A 421
LEU A 417
None
0.60A 1mx1E-1sezA:
undetectable
1mx1E-1sezA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.04A 1pxxC-1sezA:
undetectable
1pxxC-1sezA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 LEU A 479
CYH A 483
ALA A 486
LEU A  32
VAL A  18
None
1.07A 1s9pB-1sezA:
undetectable
1s9pB-1sezA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 6 PRO A 113
PHE A 200
LEU A 205
ILE A 208
None
1.20A 1sbrA-1sezA:
undetectable
1sbrB-1sezA:
undetectable
1sbrA-1sezA:
16.87
1sbrB-1sezA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 THR A 368
GLY A 394
GLY A 395
GLY A 178
SER A 335
None
None
None
OMN  A 601 (-3.6A)
None
1.19A 1wg8A-1sezA:
3.0
1wg8A-1sezA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 6 LEU A 473
ASN A 468
LEU A 450
ILE A 453
None
FAD  A 600 (-4.4A)
None
None
0.84A 1z95A-1sezA:
undetectable
1z95A-1sezA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 THR A 176
ILE A 169
VAL A 152
SER A 189
LEU A 184
None
1.23A 1z9hD-1sezA:
undetectable
1z9hD-1sezA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 LEU A  79
LEU A 479
GLY A  25
SER A 481
ALA A  48
None
1.15A 2bm9A-1sezA:
2.2
2bm9A-1sezA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 LEU A 334
ALA A 174
LEU A 184
LEU A 473
PHE A 392
OMN  A 601 (-4.7A)
None
None
None
OMN  A 601 (-3.6A)
1.48A 2oaxC-1sezA:
undetectable
2oaxC-1sezA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 11 ALA A 485
THR A 303
ALA A  28
GLY A 482
SER A 481
None
1.39A 2xfsB-1sezA:
0.0
2xfsB-1sezA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 11 SER A 481
THR A 303
ALA A 485
GLY A 482
ALA A  28
None
1.38A 2xh9A-1sezA:
0.0
2xh9A-1sezA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 10 SER A 481
THR A 303
ALA A 485
GLY A 482
ALA A  28
None
1.37A 2xh9B-1sezA:
0.0
2xh9B-1sezA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 LEU A 334
GLY A 395
LEU A 401
ASP A 180
LEU A 369
OMN  A 601 (-4.7A)
None
None
None
OMN  A 601 (-3.7A)
1.00A 3cjtC-1sezA:
3.9
3cjtC-1sezA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 LEU A 306
GLY A 467
MET A 456
LEU A 463
ILE A  19
None
FAD  A 600 ( 4.4A)
None
None
FAD  A 600 (-4.7A)
1.40A 3h52A-1sezA:
undetectable
3h52A-1sezA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1A-1sezA:
undetectable
3ln1A-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1B-1sezA:
undetectable
3ln1B-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1C-1sezA:
undetectable
3ln1C-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1D-1sezA:
undetectable
3ln1D-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 337
SER A 335
LEU A 409
ALA A 438
GLY A 370
None
None
None
FAD  A 600 (-3.7A)
OMN  A 601 (-3.5A)
0.98A 3ln1D-1sezA:
undetectable
3ln1D-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 11 GLN A 157
ASP A 182
LEU A 184
VAL A 173
ALA A 174
None
1.09A 3n23C-1sezA:
0.0
3n23C-1sezA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.09A 3nt1A-1sezA:
0.0
3nt1A-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.09A 3nt1B-1sezA:
0.0
3nt1B-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.03A 3pghD-1sezA:
0.0
3pghD-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 3rr3A-1sezA:
undetectable
3rr3A-1sezA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 4coxA-1sezA:
undetectable
4coxA-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.07A 4coxB-1sezA:
undetectable
4coxB-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.07A 4coxC-1sezA:
undetectable
4coxC-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.07A 4coxD-1sezA:
undetectable
4coxD-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 7 LEU A 473
ASN A 468
LEU A 450
ILE A 453
None
FAD  A 600 (-4.4A)
None
None
0.83A 4okwA-1sezA:
undetectable
4okwA-1sezA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 4rrwA-1sezA:
undetectable
4rrwA-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 4rrzA-1sezA:
undetectable
4rrzA-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
3 / 3 GLU A 424
LYS A 347
ASN A 345
None
0.99A 4y1dA-1sezA:
undetectable
4y1dD-1sezA:
undetectable
4y1dA-1sezA:
15.08
4y1dD-1sezA:
1.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 8 ALA A 466
GLY A 482
ALA A  28
GLY A  25
None
0.68A 4zjzA-1sezA:
undetectable
4zjzA-1sezA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 5ikqA-1sezA:
undetectable
5ikqA-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.04A 5ikrB-1sezA:
0.0
5ikrB-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 5jvzA-1sezA:
0.0
5jvzA-1sezA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 5kirA-1sezA:
undetectable
5kirA-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.08A 5kirB-1sezA:
undetectable
5kirB-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 ALA A  21
GLY A  22
ASN A 484
LEU A 479
GLU A  73
None
FAD  A 600 (-3.3A)
None
None
None
1.19A 5nwuA-1sezA:
undetectable
5nwuA-1sezA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 6 PRO A 181
LEU A 356
PHE A 172
LEU A 168
None
OMN  A 601 ( 4.7A)
TON  A 603 (-3.9A)
TON  A 603 (-4.5A)
1.21A 5tl8A-1sezA:
undetectable
5tl8A-1sezA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 ALA A 486
VAL A  41
GLY A  22
ALA A  21
LEU A 253
None
None
FAD  A 600 (-3.3A)
None
None
0.93A 5xxiA-1sezA:
undetectable
5xxiA-1sezA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 GLY A 175
THR A 176
CYH A 177
GLY A 178
LEU A 420
OMN  A 601 (-3.6A)
None
None
OMN  A 601 (-3.6A)
None
0.96A 5ybbA-1sezA:
undetectable
5ybbA-1sezA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 8 GLY A 370
PHE A 392
VAL A 337
GLY A 179
ALA A 438
OMN  A 601 (-3.5A)
OMN  A 601 (-3.6A)
None
None
FAD  A 600 (-3.7A)
1.43A 6hu9H-1sezA:
undetectable
6hu9e-1sezA:
undetectable
6hu9H-1sezA:
11.36
6hu9e-1sezA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 ILE A  19
GLY A  20
GLY A  22
ALA A  27
VAL A 264
FAD  A 600 (-4.7A)
FAD  A 600 (-3.4A)
FAD  A 600 (-3.3A)
None
FAD  A 600 (-3.8A)
0.74A 6iftA-1sezA:
3.2
6iftA-1sezA:
22.03