SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_B_SAMB300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	1sfc	PROTEIN (SYNAPTOBREVIN 2) PROTEIN (SYNTAXIN 1A) (Rattus norvegicus; Rattus norvegicus)	3 / 3	TYR B 235 ASP A 64 ASP A 57	None	0.87A	3ou6B-1sfcB: undetectable	3ou6B-1sfcB: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QX3_A_EVPA1_1 (DNA TOPOISOMERASE 2-BETA)	1sfc	PROTEIN (SNAP-25B) PROTEIN (SYNAPTOBREVIN 2) PROTEIN (SYNTAXIN 1A) (Rattus norvegicus)	4 / 5	GLY D 132 ASP D 147 ARG B 198 GLN A 36	None	1.34A	3qx3A-1sfcD: undetectable	3qx3A-1sfcD: 8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_B_SAMB601_1 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	1sfc	PROTEIN (SYNAPTOBREVIN 2) PROTEIN (SYNTAXIN 1A) (Rattus norvegicus; Rattus norvegicus)	4 / 4	LYS B 204 ASP A 44 ASN A 49 SER B 208	None	1.48A	4obwB-1sfcB: undetectable	4obwB-1sfcB: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R82_A_ACTA205_0 (OXIDOREDUCTASE)	1sfc	PROTEIN (SNAP-25B) (Rattus norvegicus)	4 / 5	SER D 154 GLY D 155 GLU D 151 PHE D 133	None	1.31A	4r82A-1sfcD: undetectable 4r82B-1sfcD: undetectable	4r82A-1sfcD: 19.30 4r82B-1sfcD: 19.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OU6_B_SAMB300_1","SAM-DEPENDENT METHYLTRANSFERASE","1sfc","PROTEIN (SYNAPTOBREVIN 2);PROTEIN (SYNTAXIN 1A)","Rattus norvegicus;Rattus norvegicus",3,"TYR B 235;ASP A  64;ASP A  57","None","0.87A","3ou6B-1sfcB:undetectable","3ou6B-1sfcB:16.44"],["3QX3_A_EVPA1_1","DNA TOPOISOMERASE 2-BETA","1sfc","PROTEIN (SNAP-25B);PROTEIN (SYNAPTOBREVIN 2);PROTEIN (SYNTAXIN 1A)","Rattus norvegicus",4,"GLY D 132;ASP D 147;ARG B 198;GLN A  36","None","1.34A","3qx3A-1sfcD:undetectable","3qx3A-1sfcD:8.92"],["4OBW_B_SAMB601_1","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","1sfc","PROTEIN (SYNAPTOBREVIN 2);PROTEIN (SYNTAXIN 1A)","Rattus norvegicus;Rattus norvegicus",4,"LYS B 204;ASP A  44;ASN A  49;SER B 208","None","1.48A","4obwB-1sfcB:undetectable","4obwB-1sfcB:17.53"],["4R82_A_ACTA205_0","OXIDOREDUCTASE","1sfc","PROTEIN (SNAP-25B)","Rattus norvegicus",4,"SER D 154;GLY D 155;GLU D 151;PHE D 133","None","1.31A","4r82A-1sfcD:undetectable;4r82B-1sfcD:undetectable","4r82A-1sfcD:19.30;4r82B-1sfcD:19.30"]]