SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A  29
LEU A  51
LEU A  47
LEU A 140
 None
 0.89A 1ereE-1sfeA:
undetectable		 1ereE-1sfeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A  29
LEU A  51
LEU A  47
LEU A 140
 None
 0.91A 1ereF-1sfeA:
undetectable		 1ereF-1sfeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A  90
PHE A  55
ARG A  92
 None
 0.81A 2a3aA-1sfeA:
undetectable		 2a3aA-1sfeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A  24
ASP A  20
ARG A  25
GLY A  41
 None
 0.91A 5cdnR-1sfeA:
0.1
5cdnS-1sfeA:
undetectable		 5cdnR-1sfeA:
18.71
5cdnS-1sfeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A  24
ASP A  20
ARG A  25
GLY A  41
 None
 0.91A 5cdnC-1sfeA:
0.0
5cdnD-1sfeA:
undetectable		 5cdnC-1sfeA:
18.71
5cdnD-1sfeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A  24
ASP A  20
ARG A  25
GLY A  41
 None
 0.93A 5cdnT-1sfeA:
undetectable
5cdnU-1sfeA:
undetectable		 5cdnT-1sfeA:
18.71
5cdnU-1sfeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A  24
ASP A  20
ARG A  25
GLY A  41
 None
 0.97A 5cdpA-1sfeA:
undetectable
5cdpB-1sfeA:
undetectable		 5cdpA-1sfeA:
18.45
5cdpB-1sfeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 CYH A 135
LEU A 118
LEU A 104
ALA A 103
 None
 0.80A 5hpuA-1sfeA:
undetectable
5hpuB-1sfeA:
undetectable		 5hpuA-1sfeA:
10.27
5hpuB-1sfeA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		5 / 9 VAL A 143
LEU A  78
VAL A  28
HIS A  70
ILE A  38
 None
 1.21A 5om2A-1sfeA:
undetectable
5om2B-1sfeA:
undetectable		 5om2A-1sfeA:
18.54
5om2B-1sfeA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 VAL A 131
VAL A 128
TYR A 115
GLN A 117
 None
 1.36A 5qggA-1sfeA:
undetectable		 5qggA-1sfeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 VAL A 131
VAL A 128
TYR A 115
GLN A 117
 None
 1.37A 5qgoA-1sfeA:
undetectable		 5qgoA-1sfeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 VAL A 131
VAL A 128
TYR A 115
GLN A 117
 None
 1.40A 5qgpA-1sfeA:
undetectable		 5qgpA-1sfeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 VAL A 131
VAL A 128
TYR A 115
GLN A 117
 None
 1.41A 5qgqA-1sfeA:
undetectable		 5qgqA-1sfeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 VAL A 131
VAL A 128
TYR A 115
GLN A 117
 None
 1.37A 5qhbA-1sfeA:
undetectable		 5qhbA-1sfeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  27
LEU A  51
GLY A  34
ARG A  33
ASN A 138
 None
 1.01A 6ce2B-1sfeA:
undetectable		 6ce2B-1sfeA:
19.02