SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 7 VAL A   4
ARG A 202
ILE A 192
GLY A 210
 None
DHK  A 239 (-2.6A)
DHK  A 239 ( 4.2A)
None
 0.96A 11gsA-1sfjA:
undetectable		 11gsA-1sfjA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 12 LEU A  34
GLN A  22
ARG A  27
ILE A  31
PHE A  63
 None
 1.46A 1skxA-1sfjA:
undetectable		 1skxA-1sfjA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 8 VAL A   4
ARG A 202
ILE A 192
GLY A 210
 None
DHK  A 239 (-2.6A)
DHK  A 239 ( 4.2A)
None
 0.93A 2gssA-1sfjA:
undetectable		 2gssA-1sfjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 8 VAL A   4
ARG A 202
ILE A 192
GLY A 210
 None
DHK  A 239 (-2.6A)
DHK  A 239 ( 4.2A)
None
 0.93A 2gssB-1sfjA:
undetectable		 2gssB-1sfjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 6 ASP A  39
ILE A  38
LEU A  92
GLU A  35
 None
None
None
DHK  A 239 (-3.1A)
 1.04A 2ya7B-1sfjA:
undetectable		 2ya7B-1sfjA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 11 HIS A 133
LEU A 144
GLY A 191
VAL A 189
HIS A 132
 DHK  A 239 (-4.8A)
None
None
None
None
 1.15A 2yy8A-1sfjA:
undetectable
2yy8B-1sfjA:
2.6		 2yy8A-1sfjA:
19.69
2yy8B-1sfjA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		3 / 3 GLU A 136
HIS A 133
HIS A 132
 None
DHK  A 239 (-4.8A)
None
 0.90A 3co4A-1sfjA:
11.1		 3co4A-1sfjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 10 ILE A 226
SER A 195
GLY A 224
SER A 193
LEU A 231
 None
 1.35A 3ik6B-1sfjA:
undetectable
3ik6E-1sfjA:
undetectable		 3ik6B-1sfjA:
23.55
3ik6E-1sfjA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 12 HIS A 114
ILE A 118
VAL A 128
ILE A 101
ILE A  89
 None
 1.24A 3kpbC-1sfjA:
undetectable		 3kpbC-1sfjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 8 VAL A   4
ARG A 202
ILE A 192
GLY A 210
 None
DHK  A 239 (-2.6A)
DHK  A 239 ( 4.2A)
None
 0.93A 3n9jA-1sfjA:
undetectable		 3n9jA-1sfjA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 4 ILE A  89
ARG A  70
TYR A  85
GLU A 104
 None
DHK  A 239 (-3.6A)
None
None
 1.41A 4zzbD-1sfjA:
undetectable		 4zzbD-1sfjA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 7 ASP A 102
THR A  68
TYR A  69
THR A  71
 None
DHK  A 239 ( 3.8A)
None
None
 1.00A 5b6iA-1sfjA:
undetectable		 5b6iA-1sfjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 6 ASP A 102
THR A  68
TYR A  69
THR A  71
 None
DHK  A 239 ( 3.8A)
None
None
 0.99A 5b6iB-1sfjA:
undetectable		 5b6iB-1sfjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		4 / 5 GLN A 122
HIS A 120
ILE A 118
ILE A  89
 None
 1.21A 5dnuA-1sfjA:
2.2		 5dnuA-1sfjA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		5 / 8 VAL A  49
ILE A 101
ILE A  38
ILE A  89
ASP A  91
 None
 1.15A 5hi2A-1sfjA:
undetectable		 5hi2A-1sfjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		6 / 12 GLY A 206
GLY A 209
SER A 179
LEU A 175
VAL A 235
THR A 236
 None
 1.46A 5kpcA-1sfjA:
undetectable		 5kpcA-1sfjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		3 / 3 PHE A 181
ASP A 183
LEU A 172
 None
 0.69A 5uhbC-1sfjA:
undetectable		 5uhbC-1sfjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		3 / 3 PHE A 181
ASP A 183
LEU A 172
 None
 0.60A 5uhcC-1sfjA:
undetectable		 5uhcC-1sfjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		3 / 3 THR A  71
GLU A 104
HIS A 132
 None
 0.85A 5xioA-1sfjA:
undetectable		 5xioA-1sfjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		3 / 3 THR A  71
GLU A 104
HIS A 132
 None
 0.87A 5xiqB-1sfjA:
undetectable		 5xiqB-1sfjA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1sfj 3-DEHYDROQUINATE
DEHYDRATASE
(Staphylococcus
aureus) 		3 / 3 THR A  71
GLU A 104
HIS A 132
 None
 0.81A 5xiqD-1sfjA:
undetectable		 5xiqD-1sfjA:
18.29