SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 8 TYR A1237
LEU A1191
SER A1115
GLU A1118
 None
 0.97A 1i7zA-1sfnA:
undetectable		 1i7zA-1sfnA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		3 / 3 LEU A1190
LEU A1236
SER A1168
 None
 0.32A 1tlmA-1sfnA:
undetectable		 1tlmA-1sfnA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 GLU A1194
SER A1171
ARG A1154
TYR A1093
 None
 1.49A 1tufA-1sfnA:
undetectable
1tufB-1sfnA:
undetectable		 1tufA-1sfnA:
20.09
1tufB-1sfnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 8 PHE A1023
ARG A1008
ALA A1210
LEU A1191
 None
 1.18A 1x8vA-1sfnA:
undetectable		 1x8vA-1sfnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 8 PHE A1172
LEU A1178
LEU A1236
LEU A1190
 None
 0.99A 2bfpB-1sfnA:
undetectable		 2bfpB-1sfnA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		3 / 3 MET A1192
VAL A1037
GLU A1021
 None
 0.89A 2x9gA-1sfnA:
undetectable		 2x9gA-1sfnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 8 PHE A1163
VAL A1096
LEU A1098
PRO A1099
 None
 1.03A 3jq7C-1sfnA:
undetectable		 3jq7C-1sfnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 PHE A1050
ASP A1239
TYR A1237
PRO A1042
 None
 1.37A 3jqaA-1sfnA:
undetectable		 3jqaA-1sfnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 PHE A1050
ASP A1239
TYR A1237
PRO A1042
 None
 1.35A 3jqaB-1sfnA:
undetectable		 3jqaB-1sfnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 PHE A1050
ASP A1239
TYR A1237
PRO A1042
 None
 1.38A 3jqaC-1sfnA:
undetectable		 3jqaC-1sfnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 PHE A1050
ASP A1239
TYR A1237
PRO A1042
 None
 1.37A 3jqaD-1sfnA:
undetectable		 3jqaD-1sfnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		3 / 3 ARG A1049
TRP A1215
GLY A1217
 None
 0.95A 4e7cA-1sfnA:
undetectable		 4e7cA-1sfnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A1038
LEU A1028
GLN A1052
ILE A1018
PHE A1023
 None
 1.36A 4p6xA-1sfnA:
undetectable		 4p6xA-1sfnA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A1038
LEU A1028
GLN A1052
ILE A1018
PHE A1023
 None
 1.25A 4p6xE-1sfnA:
undetectable		 4p6xE-1sfnA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A1038
LEU A1028
GLN A1052
ILE A1018
PHE A1023
 None
 1.25A 4p6xI-1sfnA:
undetectable		 4p6xI-1sfnA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 8 LEU A1028
VAL A1051
VAL A1116
TYR A1068
 None
 1.19A 4q0bA-1sfnA:
undetectable		 4q0bA-1sfnA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1sfn CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 7 ASN A1140
LYS A1155
TYR A1234
LEU A1193
 None
 1.25A 4yv5B-1sfnA:
undetectable		 4yv5B-1sfnA:
19.09