SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 154
VAL A 158
TRP A 189
 None
 0.72A 1av2C-1sfsA:
undetectable
1av2D-1sfsA:
undetectable		 1av2C-1sfsA:
7.59
1av2D-1sfsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 116
VAL A 118
TRP A 117
 None
 0.88A 1bdwA-1sfsA:
undetectable
1bdwB-1sfsA:
undetectable		 1bdwA-1sfsA:
7.59
1bdwB-1sfsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 154
VAL A 158
TRP A 189
 None
 0.72A 1w5uC-1sfsA:
undetectable
1w5uD-1sfsA:
undetectable		 1w5uC-1sfsA:
7.59
1w5uD-1sfsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A  36
PRO A  63
LEU A  46
ARG A  48
 None
 1.38A 2hrcA-1sfsA:
undetectable		 2hrcA-1sfsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 189
ALA A 154
VAL A 158
 None
 0.76A 2izqA-1sfsA:
undetectable
2izqB-1sfsA:
undetectable		 2izqA-1sfsA:
7.59
2izqB-1sfsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A  68
ILE A 103
GLY A 129
ILE A 159
 None
 0.83A 2qwxA-1sfsA:
undetectable
2qwxB-1sfsA:
undetectable		 2qwxA-1sfsA:
22.26
2qwxB-1sfsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A  36
PRO A  63
LEU A  46
ARG A  48
 None
 1.39A 3hcoA-1sfsA:
undetectable		 3hcoA-1sfsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 154
VAL A 158
TRP A 189
 None
 0.73A 3l8lA-1sfsA:
undetectable
3l8lB-1sfsA:
undetectable		 3l8lA-1sfsA:
7.59
3l8lB-1sfsA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 154
VAL A 158
TRP A 189
 None
 0.75A 3l8lC-1sfsA:
undetectable
3l8lD-1sfsA:
undetectable		 3l8lC-1sfsA:
7.59
3l8lD-1sfsA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  36
TYR A  35
GLY A   7
LEU A  99
GLY A 129
 None
 1.17A 4blvA-1sfsA:
undetectable		 4blvA-1sfsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 PRO A 201
VAL A 202
PRO A  29
GLN A  20
 None
 1.07A 4iilA-1sfsA:
undetectable		 4iilA-1sfsA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A  68
ILE A 103
GLY A 129
ILE A 159
 None
 0.81A 4qogA-1sfsA:
undetectable
4qogB-1sfsA:
undetectable		 4qogA-1sfsA:
22.26
4qogB-1sfsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 THR A 120
ALA A 115
ALA A 146
GLY A  77
ASP A 110
 None
None
None
None
PO4  A 217 (-4.6A)
 1.11A 4qwuK-1sfsA:
undetectable
4qwuL-1sfsA:
undetectable		 4qwuK-1sfsA:
20.45
4qwuL-1sfsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 THR A 120
ALA A 115
ALA A 146
GLY A  77
ASP A 110
 None
None
None
None
PO4  A 217 (-4.6A)
 1.17A 4qwuY-1sfsA:
undetectable
4qwuZ-1sfsA:
undetectable		 4qwuY-1sfsA:
20.45
4qwuZ-1sfsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 ARG A 195
PHE A 107
ARG A  69
TYR A 131
 None
 1.33A 5a06B-1sfsA:
undetectable		 5a06B-1sfsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 ARG A 195
PHE A 107
ARG A  69
TYR A 131
 None
 1.31A 5a06F-1sfsA:
2.4		 5a06F-1sfsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A   9
VAL A  59
ILE A  54
ILE A  64
 None
 0.94A 5hw8H-1sfsA:
undetectable		 5hw8H-1sfsA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1sfs HYPOTHETICAL PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 THR A 120
ALA A 115
ALA A 146
GLY A  77
ASP A 110
 None
None
None
None
PO4  A 217 (-4.6A)
 1.02A 5l5zY-1sfsA:
undetectable
5l5zZ-1sfsA:
undetectable		 5l5zY-1sfsA:
17.53
5l5zZ-1sfsA:
21.03