SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  54
ILE A  24
LEU A  27
ARG A  31
 None
 0.88A 2byoA-1sfxA:
0.0		 2byoA-1sfxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008
(Archaeoglobus
fulgidus) 		3 / 3 LEU A   5
PRO A   4
LEU A   8
 None
 0.63A 2po5B-1sfxA:
undetectable		 2po5B-1sfxA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  18
PRO A  19
SER A  20
 None
CL  A 501 (-4.0A)
CL  A 501 (-3.2A)
 0.42A 4k50I-1sfxA:
undetectable		 4k50I-1sfxA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  64
LYS A  81
TYR A  25
 None
 1.20A 6gnaA-1sfxA:
undetectable		 6gnaA-1sfxA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  64
LYS A  81
TYR A  25
 None
 1.20A 6gnbA-1sfxA:
undetectable		 6gnbA-1sfxA:
18.73