SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 150
ILE A  38
LEU A  36
LEU A 114
LEU A 100
 None
 1.35A 1eiiA-1sg4A:
0.0		 1eiiA-1sg4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 156
HIS A 157
ALA A 163
ILE A 155
 None
 0.79A 1gtnE-1sg4A:
undetectable
1gtnF-1sg4A:
undetectable		 1gtnE-1sg4A:
13.69
1gtnF-1sg4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 156
HIS A 157
ALA A 163
ILE A 155
 None
 0.82A 1gtnP-1sg4A:
undetectable
1gtnQ-1sg4A:
undetectable		 1gtnP-1sg4A:
13.69
1gtnQ-1sg4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 112
GLY A 111
LEU A  28
SER A  29
LEU A  66
 None
 1.14A 1ya4B-1sg4A:
undetectable		 1ya4B-1sg4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 11 VAL A  15
ALA A  16
MET A  18
LEU A  98
VAL A  99
MET A 202
 None
 1.39A 2c12B-1sg4A:
undetectable		 2c12B-1sg4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL A  15
ALA A  16
MET A  18
LEU A  98
VAL A  99
 None
 1.25A 2c12D-1sg4A:
undetectable		 2c12D-1sg4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TRP A  83
ALA A 230
VAL A 232
 None
 1.00A 3l8lC-1sg4A:
undetectable
3l8lD-1sg4A:
undetectable		 3l8lC-1sg4A:
6.06
3l8lD-1sg4A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ALA A  13
VAL A  15
ASP A  10
LEU A 195
 None
 0.86A 4e7gA-1sg4A:
0.0		 4e7gA-1sg4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 172
CYH A 131
ALA A 163
GLY A 167
LEU A 166
 None
 1.30A 4oadA-1sg4A:
0.9		 4oadA-1sg4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  54
GLY A 112
GLY A  65
ASN A  26
CYH A 119
 None
 1.22A 4x61A-1sg4A:
undetectable		 4x61A-1sg4A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 143
GLU A 136
LEU A 151
LEU A 134
HIS A 157
 None
 1.22A 4zn7A-1sg4A:
undetectable		 4zn7A-1sg4A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 105
TYR A 130
CYH A 108
 None
 1.09A 5lsuB-1sg4A:
undetectable		 5lsuB-1sg4A:
21.55