SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sg9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NV8_A_SAMA300_0 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	7 / 12	PHE A 100 PRO A 102 GLY A 129 GLY A 131 THR A 150 PHE A 180 PRO A 198	SAM A 301 ( 3.4A) SAM A 301 (-3.6A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) None SAM A 301 (-3.5A) GLN A 400 (-4.9A)	1.42A	1nv8A-1sg9A: 39.7	1nv8A-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NV8_A_SAMA300_0 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	12 / 12	PHE A 100 PRO A 102 THR A 106 ILE A 128 GLY A 129 GLY A 131 THR A 150 VAL A 152 PHE A 180 ASN A 197 PRO A 199 ALA A 218	SAM A 301 ( 3.4A) SAM A 301 (-3.6A) SAM A 301 (-3.4A) None SAM A 301 (-3.3A) SAM A 301 ( 3.8A) None SAM A 301 (-4.3A) SAM A 301 (-3.5A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A) SAM A 301 (-3.3A)	0.19A	1nv8A-1sg9A: 39.7	1nv8A-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NV8_B_SAMB301_0 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	12 / 12	PHE A 100 THR A 106 ILE A 128 GLY A 129 GLY A 131 ILE A 135 THR A 150 VAL A 152 GLU A 179 PHE A 180 PRO A 199 ALA A 218	SAM A 301 ( 3.4A) SAM A 301 (-3.4A) None SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 (-4.8A) None SAM A 301 (-4.3A) None SAM A 301 (-3.5A) SAM A 301 ( 4.6A) SAM A 301 (-3.3A)	0.18A	1nv8B-1sg9A: 41.5	1nv8B-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SG9_A_SAMA301_0 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	6 / 12	PHE A 100 PRO A 102 GLY A 131 THR A 150 PHE A 180 PRO A 198	SAM A 301 ( 3.4A) SAM A 301 (-3.6A) SAM A 301 ( 3.8A) None SAM A 301 (-3.5A) GLN A 400 (-4.9A)	1.45A	1sg9A-1sg9A: 46.2	1sg9A-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SG9_A_SAMA301_0 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	12 / 12	PHE A 100 PRO A 102 ILE A 128 GLY A 131 ILE A 135 THR A 150 VAL A 152 SER A 153 GLU A 179 PHE A 180 ASN A 197 PRO A 199	SAM A 301 ( 3.4A) SAM A 301 (-3.6A) None SAM A 301 ( 3.8A) SAM A 301 (-4.8A) None SAM A 301 (-4.3A) None None SAM A 301 (-3.5A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A)	0.05A	1sg9A-1sg9A: 46.2	1sg9A-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SG9_A_SAMA301_1 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 4	THR A 106 GLY A 129 ASP A 151 ALA A 218	SAM A 301 (-3.4A) SAM A 301 (-3.3A) SAM A 301 (-2.9A) SAM A 301 (-3.3A)	0.00A	1sg9A-1sg9A: 46.2	1sg9A-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SG9_B_SAMB302_0 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	12 / 12	PHE A 100 PRO A 102 THR A 106 ILE A 128 GLY A 129 GLY A 131 ILE A 135 VAL A 152 SER A 153 GLU A 179 PRO A 199 ALA A 218	SAM A 301 ( 3.4A) SAM A 301 (-3.6A) SAM A 301 (-3.4A) None SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 (-4.8A) SAM A 301 (-4.3A) None None SAM A 301 ( 4.6A) SAM A 301 (-3.3A)	0.14A	1sg9B-1sg9A: 43.8	1sg9B-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SG9_B_SAMB302_1 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	3 / 3	ASP A 151 PHE A 180 ASN A 197	SAM A 301 (-2.9A) SAM A 301 (-3.5A) GLN A 400 ( 3.1A)	0.10A	1sg9B-1sg9A: 43.8	1sg9B-1sg9A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SG9_C_SAMC303_0 (HEMK PROTEIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	12 / 12	PHE A 100 PRO A 102 ILE A 128 GLY A 131 ALA A 134 VAL A 152 SER A 153 GLU A 179 PHE A 180 ASN A 197 PRO A 199 ALA A 218	SAM A 301 ( 3.4A) SAM A 301 (-3.6A) None SAM A 301 ( 3.8A) SAM A 301 ( 4.0A) SAM A 301 (-4.3A) None None SAM A 301 (-3.5A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A) SAM A 301 (-3.3A)	0.15A	1sg9C-1sg9A: 43.7	1sg9C-1sg9A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V8B_B_ADNB1502_2 (ADENOSYLHOMOCYSTEINA SE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	3 / 3	GLU A 97 GLU A 217 LEU A 207	None	0.72A	1v8bB-1sg9A: 2.6	1v8bB-1sg9A: 23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1VQ1_A_SAMA301_0 (N5-GLUTAMINE METHYLTRANSFERASE, HEMK)	1sg9	HEMK PROTEIN (Thermotoga maritima)	12 / 12	PHE A 100 THR A 106 ILE A 128 GLY A 131 ALA A 134 ILE A 135 THR A 150 VAL A 152 GLU A 179 PHE A 180 PRO A 199 ALA A 218	SAM A 301 ( 3.4A) SAM A 301 (-3.4A) None SAM A 301 ( 3.8A) SAM A 301 ( 4.0A) SAM A 301 (-4.8A) None SAM A 301 (-4.3A) None SAM A 301 (-3.5A) SAM A 301 ( 4.6A) SAM A 301 (-3.3A)	0.22A	1vq1A-1sg9A: 39.6	1vq1A-1sg9A: 95.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1VQ1_A_SAMA301_1 (N5-GLUTAMINE METHYLTRANSFERASE, HEMK)	1sg9	HEMK PROTEIN (Thermotoga maritima)	3 / 3	GLY A 129 ASP A 151 ASN A 197	SAM A 301 (-3.3A) SAM A 301 (-2.9A) GLN A 400 ( 3.1A)	0.10A	1vq1A-1sg9A: 39.6	1vq1A-1sg9A: 95.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1VQ1_B_SAMB301_0 (N5-GLUTAMINE METHYLTRANSFERASE, HEMK)	1sg9	HEMK PROTEIN (Thermotoga maritima)	12 / 12	PHE A 100 THR A 106 ILE A 128 GLY A 129 GLY A 131 SER A 132 ILE A 135 VAL A 152 GLU A 179 PHE A 180 PRO A 199 ALA A 218	SAM A 301 ( 3.4A) SAM A 301 (-3.4A) None SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 ( 4.8A) SAM A 301 (-4.8A) SAM A 301 (-4.3A) None SAM A 301 (-3.5A) SAM A 301 ( 4.6A) SAM A 301 (-3.3A)	0.31A	1vq1B-1sg9A: 39.0	1vq1B-1sg9A: 95.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOJ_C_FRDC305_2 (POL POLYPROTEIN PEPTIDE INHIBITOR)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 7	LEU A 116 GLY A 136 ILE A 135 ILE A 117	None None SAM A 301 (-4.8A) None	0.79A	2aojB-1sg9A: undetectable	2aojB-1sg9A: 16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BYO_A_LNLA1216_1 (LIPOPROTEIN LPPX)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 5	LEU A 181 ILE A 194 LEU A 195 SER A 196	None	0.86A	2byoA-1sg9A: 0.0	2byoA-1sg9A: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_A_SAMA302_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 12	PHE A 100 ASP A 127 GLY A 129 GLY A 131 ASN A 197	SAM A 301 ( 3.4A) SAM A 301 ( 4.9A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) GLN A 400 ( 3.1A)	0.34A	2nxeA-1sg9A: 16.5	2nxeA-1sg9A: 25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_B_SAMB303_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 12	PHE A 100 ASP A 127 GLY A 129 GLY A 131 ASN A 197	SAM A 301 ( 3.4A) SAM A 301 ( 4.9A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) GLN A 400 ( 3.1A)	0.39A	2nxeB-1sg9A: 16.7	2nxeB-1sg9A: 25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZUL_A_SAMA376_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 12	PHE A 100 ALA A 134 ASN A 197 PRO A 199 PHE A 228	SAM A 301 ( 3.4A) SAM A 301 ( 4.0A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A) None	1.06A	2zulA-1sg9A: 18.5	2zulA-1sg9A: 23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZUL_A_SAMA376_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	6 / 12	PHE A 100 GLY A 129 GLY A 131 ALA A 134 ASN A 197 PRO A 199	SAM A 301 ( 3.4A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 ( 4.0A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A)	0.49A	2zulA-1sg9A: 18.5	2zulA-1sg9A: 23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BRF_A_SORA1_0 (LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A)	1sg9	HEMK PROTEIN (Thermotoga maritima)	3 / 3	GLY A 131 ASP A 151 SER A 153	SAM A 301 ( 3.8A) SAM A 301 (-2.9A) None	0.58A	3brfA-1sg9A: undetectable	3brfA-1sg9A: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMF_A_SAMA388_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 12	PHE A 100 ALA A 134 ASN A 197 PRO A 199 PHE A 228	SAM A 301 ( 3.4A) SAM A 301 ( 4.0A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A) None	1.03A	3dmfA-1sg9A: 18.5	3dmfA-1sg9A: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMF_A_SAMA388_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	6 / 12	PHE A 100 GLY A 129 GLY A 131 ALA A 134 ASN A 197 PRO A 199	SAM A 301 ( 3.4A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 ( 4.0A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A)	0.48A	3dmfA-1sg9A: 18.5	3dmfA-1sg9A: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMH_A_SAMA384_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 12	PHE A 100 ALA A 134 ASN A 197 PRO A 199 PHE A 228	SAM A 301 ( 3.4A) SAM A 301 ( 4.0A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A) None	1.00A	3dmhA-1sg9A: 12.8	3dmhA-1sg9A: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMH_A_SAMA384_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	6 / 12	PHE A 100 GLY A 129 GLY A 131 ALA A 134 ASN A 197 PRO A 199	SAM A 301 ( 3.4A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 ( 4.0A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A)	0.45A	3dmhA-1sg9A: 12.8	3dmhA-1sg9A: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_G_TRPG1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 8	GLY A 23 ILE A 18 VAL A 36 VAL A 70	None	0.73A	3fi0G-1sg9A: undetectable	3fi0G-1sg9A: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q87_B_SAMB300_0 (N6 ADENINE SPECIFIC DNA METHYLASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	6 / 12	THR A 106 GLY A 129 ILE A 135 ASP A 151 ASN A 197 PRO A 199	SAM A 301 (-3.4A) SAM A 301 (-3.3A) SAM A 301 (-4.8A) SAM A 301 (-2.9A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A)	0.90A	3q87B-1sg9A: 18.2	3q87B-1sg9A: 22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SOA_A_DB8A445_1 (CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 6	LEU A 277 VAL A 243 PHE A 232 PHE A 188	None	0.99A	3soaA-1sg9A: undetectable	3soaA-1sg9A: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A81_A_DXCA1161_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 12	GLY A 225 ASP A 224 ILE A 258 VAL A 259 MET A 245	None	1.15A	4a81A-1sg9A: undetectable	4a81A-1sg9A: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DCM_A_SAMA401_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE G)	1sg9	HEMK PROTEIN (Thermotoga maritima)	8 / 11	PHE A 100 ASP A 127 GLY A 129 GLY A 131 ILE A 135 ASP A 151 ASN A 197 PRO A 199	SAM A 301 ( 3.4A) SAM A 301 ( 4.9A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 (-4.8A) SAM A 301 (-2.9A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A)	0.57A	4dcmA-1sg9A: 17.2	4dcmA-1sg9A: 22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAT_A_BEZA1000_0 (BENZOATE-COENZYME A LIGASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 7	ALA A 156 ALA A 149 ILE A 128 GLY A 129	SAM A 301 ( 4.7A) None None SAM A 301 (-3.3A)	0.59A	4eatA-1sg9A: 2.4	4eatA-1sg9A: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_SAMA401_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 12	GLY A 129 GLY A 131 ILE A 135 ASN A 197 PRO A 199	SAM A 301 (-3.3A) SAM A 301 ( 3.8A) SAM A 301 (-4.8A) GLN A 400 ( 3.1A) SAM A 301 ( 4.6A)	0.50A	4gc9A-1sg9A: 9.7	4gc9A-1sg9A: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MGH_A_ACTA1320_0 (PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 5	VAL A 40 LEU A 51 ILE A 14 LEU A 17	None	0.84A	4mghA-1sg9A: undetectable	4mghA-1sg9A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 4	GLY A 136 LEU A 181 PHE A 188 ILE A 194	None	0.84A	4xv2A-1sg9A: undetectable	4xv2A-1sg9A: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBR_A_ACTA608_0 (SERUM ALBUMIN)	1sg9	HEMK PROTEIN (Thermotoga maritima)	3 / 3	LYS A 162 ARG A 166 HIS A 167	None	1.25A	4zbrA-1sg9A: 2.8	4zbrA-1sg9A: 18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJZ_B_BEZB601_0 (BENZOATE-COENZYME A LIGASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 8	ALA A 160 VAL A 175 PHE A 173 GLY A 133 ALA A 134	None None None None SAM A 301 ( 4.0A)	1.36A	4zjzB-1sg9A: 3.2	4zjzB-1sg9A: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_B_ACRB1421_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1sg9	HEMK PROTEIN (Thermotoga maritima)	4 / 6	GLU A 246 TYR A 200 GLY A 225 GLY A 222	GLN A 400 ( 4.8A) GLN A 400 (-3.2A) None None	0.74A	5x7pB-1sg9A: undetectable	5x7pB-1sg9A: 12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NQA_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 10	ASP A 127 GLY A 129 GLY A 131 ASN A 197 PHE A 228	SAM A 301 ( 4.9A) SAM A 301 (-3.3A) SAM A 301 ( 3.8A) GLN A 400 ( 3.1A) None	1.12A	6nqaK-1sg9A: 8.0	6nqaK-1sg9A: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NQA_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	1sg9	HEMK PROTEIN (Thermotoga maritima)	5 / 10	THR A 106 ASP A 127 GLY A 129 ASN A 197 PHE A 228	SAM A 301 (-3.4A) SAM A 301 ( 4.9A) SAM A 301 (-3.3A) GLN A 400 ( 3.1A) None	1.48A	6nqaK-1sg9A: 8.0	6nqaK-1sg9A: 23.31

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NV8_A_SAMA300_0","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",7,"PHE A 100;PRO A 102;GLY A 129;GLY A 131;THR A 150;PHE A 180;PRO A 198","SAM A 301 ( 3.4A);SAM A 301 (-3.6A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);None;SAM A 301 (-3.5A);GLN A 400 (-4.9A)","1.42A","1nv8A-1sg9A:39.7","1nv8A-1sg9A:100.00"],["1NV8_A_SAMA300_0","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",12,"PHE A 100;PRO A 102;THR A 106;ILE A 128;GLY A 129;GLY A 131;THR A 150;VAL A 152;PHE A 180;ASN A 197;PRO A 199;ALA A 218","SAM A 301 ( 3.4A);SAM A 301 (-3.6A);SAM A 301 (-3.4A);None;SAM A 301 (-3.3A);SAM A 301 ( 3.8A);None;SAM A 301 (-4.3A);SAM A 301 (-3.5A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A);SAM A 301 (-3.3A)","0.19A","1nv8A-1sg9A:39.7","1nv8A-1sg9A:100.00"],["1NV8_B_SAMB301_0","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",12,"PHE A 100;THR A 106;ILE A 128;GLY A 129;GLY A 131;ILE A 135;THR A 150;VAL A 152;GLU A 179;PHE A 180;PRO A 199;ALA A 218","SAM A 301 ( 3.4A);SAM A 301 (-3.4A);None;SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 (-4.8A);None;SAM A 301 (-4.3A);None;SAM A 301 (-3.5A);SAM A 301 ( 4.6A);SAM A 301 (-3.3A)","0.18A","1nv8B-1sg9A:41.5","1nv8B-1sg9A:100.00"],["1SG9_A_SAMA301_0","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",6,"PHE A 100;PRO A 102;GLY A 131;THR A 150;PHE A 180;PRO A 198","SAM A 301 ( 3.4A);SAM A 301 (-3.6A);SAM A 301 ( 3.8A);None;SAM A 301 (-3.5A);GLN A 400 (-4.9A)","1.45A","1sg9A-1sg9A:46.2","1sg9A-1sg9A:100.00"],["1SG9_A_SAMA301_0","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",12,"PHE A 100;PRO A 102;ILE A 128;GLY A 131;ILE A 135;THR A 150;VAL A 152;SER A 153;GLU A 179;PHE A 180;ASN A 197;PRO A 199","SAM A 301 ( 3.4A);SAM A 301 (-3.6A);None;SAM A 301 ( 3.8A);SAM A 301 (-4.8A);None;SAM A 301 (-4.3A);None;None;SAM A 301 (-3.5A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A)","0.05A","1sg9A-1sg9A:46.2","1sg9A-1sg9A:100.00"],["1SG9_A_SAMA301_1","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"THR A 106;GLY A 129;ASP A 151;ALA A 218","SAM A 301 (-3.4A);SAM A 301 (-3.3A);SAM A 301 (-2.9A);SAM A 301 (-3.3A)","0.00A","1sg9A-1sg9A:46.2","1sg9A-1sg9A:100.00"],["1SG9_B_SAMB302_0","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",12,"PHE A 100;PRO A 102;THR A 106;ILE A 128;GLY A 129;GLY A 131;ILE A 135;VAL A 152;SER A 153;GLU A 179;PRO A 199;ALA A 218","SAM A 301 ( 3.4A);SAM A 301 (-3.6A);SAM A 301 (-3.4A);None;SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 (-4.8A);SAM A 301 (-4.3A);None;None;SAM A 301 ( 4.6A);SAM A 301 (-3.3A)","0.14A","1sg9B-1sg9A:43.8","1sg9B-1sg9A:100.00"],["1SG9_B_SAMB302_1","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",3,"ASP A 151;PHE A 180;ASN A 197","SAM A 301 (-2.9A);SAM A 301 (-3.5A);GLN A 400 ( 3.1A)","0.10A","1sg9B-1sg9A:43.8","1sg9B-1sg9A:100.00"],["1SG9_C_SAMC303_0","HEMK PROTEIN","1sg9","HEMK PROTEIN","Thermotoga maritima",12,"PHE A 100;PRO A 102;ILE A 128;GLY A 131;ALA A 134;VAL A 152;SER A 153;GLU A 179;PHE A 180;ASN A 197;PRO A 199;ALA A 218","SAM A 301 ( 3.4A);SAM A 301 (-3.6A);None;SAM A 301 ( 3.8A);SAM A 301 ( 4.0A);SAM A 301 (-4.3A);None;None;SAM A 301 (-3.5A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A);SAM A 301 (-3.3A)","0.15A","1sg9C-1sg9A:43.7","1sg9C-1sg9A:100.00"],["1V8B_B_ADNB1502_2","ADENOSYLHOMOCYSTEINASE","1sg9","HEMK PROTEIN","Thermotoga maritima",3,"GLU A  97;GLU A 217;LEU A 207","None","0.72A","1v8bB-1sg9A:2.6","1v8bB-1sg9A:23.38"],["1VQ1_A_SAMA301_0","N5-GLUTAMINE METHYLTRANSFERASE, HEMK","1sg9","HEMK PROTEIN","Thermotoga maritima",12,"PHE A 100;THR A 106;ILE A 128;GLY A 131;ALA A 134;ILE A 135;THR A 150;VAL A 152;GLU A 179;PHE A 180;PRO A 199;ALA A 218","SAM A 301 ( 3.4A);SAM A 301 (-3.4A);None;SAM A 301 ( 3.8A);SAM A 301 ( 4.0A);SAM A 301 (-4.8A);None;SAM A 301 (-4.3A);None;SAM A 301 (-3.5A);SAM A 301 ( 4.6A);SAM A 301 (-3.3A)","0.22A","1vq1A-1sg9A:39.6","1vq1A-1sg9A:95.92"],["1VQ1_A_SAMA301_1","N5-GLUTAMINE METHYLTRANSFERASE, HEMK","1sg9","HEMK PROTEIN","Thermotoga maritima",3,"GLY A 129;ASP A 151;ASN A 197","SAM A 301 (-3.3A);SAM A 301 (-2.9A);GLN A 400 ( 3.1A)","0.10A","1vq1A-1sg9A:39.6","1vq1A-1sg9A:95.92"],["1VQ1_B_SAMB301_0","N5-GLUTAMINE METHYLTRANSFERASE, HEMK","1sg9","HEMK PROTEIN","Thermotoga maritima",12,"PHE A 100;THR A 106;ILE A 128;GLY A 129;GLY A 131;SER A 132;ILE A 135;VAL A 152;GLU A 179;PHE A 180;PRO A 199;ALA A 218","SAM A 301 ( 3.4A);SAM A 301 (-3.4A);None;SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 ( 4.8A);SAM A 301 (-4.8A);SAM A 301 (-4.3A);None;SAM A 301 (-3.5A);SAM A 301 ( 4.6A);SAM A 301 (-3.3A)","0.31A","1vq1B-1sg9A:39.0","1vq1B-1sg9A:95.92"],["2AOJ_C_FRDC305_2","POL POLYPROTEIN;PEPTIDE INHIBITOR","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"LEU A 116;GLY A 136;ILE A 135;ILE A 117","None;None;SAM A 301 (-4.8A);None","0.79A","2aojB-1sg9A:undetectable","2aojB-1sg9A:16.13"],["2BYO_A_LNLA1216_1","LIPOPROTEIN LPPX","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"LEU A 181;ILE A 194;LEU A 195;SER A 196","None","0.86A","2byoA-1sg9A:0.0","2byoA-1sg9A:20.60"],["2NXE_A_SAMA302_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"PHE A 100;ASP A 127;GLY A 129;GLY A 131;ASN A 197","SAM A 301 ( 3.4A);SAM A 301 ( 4.9A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);GLN A 400 ( 3.1A)","0.34A","2nxeA-1sg9A:16.5","2nxeA-1sg9A:25.51"],["2NXE_B_SAMB303_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"PHE A 100;ASP A 127;GLY A 129;GLY A 131;ASN A 197","SAM A 301 ( 3.4A);SAM A 301 ( 4.9A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);GLN A 400 ( 3.1A)","0.39A","2nxeB-1sg9A:16.7","2nxeB-1sg9A:25.51"],["2ZUL_A_SAMA376_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"PHE A 100;ALA A 134;ASN A 197;PRO A 199;PHE A 228","SAM A 301 ( 3.4A);SAM A 301 ( 4.0A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A);None","1.06A","2zulA-1sg9A:18.5","2zulA-1sg9A:23.35"],["2ZUL_A_SAMA376_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",6,"PHE A 100;GLY A 129;GLY A 131;ALA A 134;ASN A 197;PRO A 199","SAM A 301 ( 3.4A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 ( 4.0A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A)","0.49A","2zulA-1sg9A:18.5","2zulA-1sg9A:23.35"],["3BRF_A_SORA1_0","LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A","1sg9","HEMK PROTEIN","Thermotoga maritima",3,"GLY A 131;ASP A 151;SER A 153","SAM A 301 ( 3.8A);SAM A 301 (-2.9A);None","0.58A","3brfA-1sg9A:undetectable","3brfA-1sg9A:19.18"],["3DMF_A_SAMA388_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"PHE A 100;ALA A 134;ASN A 197;PRO A 199;PHE A 228","SAM A 301 ( 3.4A);SAM A 301 ( 4.0A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A);None","1.03A","3dmfA-1sg9A:18.5","3dmfA-1sg9A:23.10"],["3DMF_A_SAMA388_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",6,"PHE A 100;GLY A 129;GLY A 131;ALA A 134;ASN A 197;PRO A 199","SAM A 301 ( 3.4A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 ( 4.0A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A)","0.48A","3dmfA-1sg9A:18.5","3dmfA-1sg9A:23.10"],["3DMH_A_SAMA384_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"PHE A 100;ALA A 134;ASN A 197;PRO A 199;PHE A 228","SAM A 301 ( 3.4A);SAM A 301 ( 4.0A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A);None","1.00A","3dmhA-1sg9A:12.8","3dmhA-1sg9A:23.10"],["3DMH_A_SAMA384_0","PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE","1sg9","HEMK PROTEIN","Thermotoga maritima",6,"PHE A 100;GLY A 129;GLY A 131;ALA A 134;ASN A 197;PRO A 199","SAM A 301 ( 3.4A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 ( 4.0A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A)","0.45A","3dmhA-1sg9A:12.8","3dmhA-1sg9A:23.10"],["3FI0_G_TRPG1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"GLY A  23;ILE A  18;VAL A  36;VAL A  70","None","0.73A","3fi0G-1sg9A:undetectable","3fi0G-1sg9A:23.91"],["3Q87_B_SAMB300_0","N6 ADENINE SPECIFIC DNA METHYLASE","1sg9","HEMK PROTEIN","Thermotoga maritima",6,"THR A 106;GLY A 129;ILE A 135;ASP A 151;ASN A 197;PRO A 199","SAM A 301 (-3.4A);SAM A 301 (-3.3A);SAM A 301 (-4.8A);SAM A 301 (-2.9A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A)","0.90A","3q87B-1sg9A:18.2","3q87B-1sg9A:22.89"],["3SOA_A_DB8A445_1","CALCIUM\/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"LEU A 277;VAL A 243;PHE A 232;PHE A 188","None","0.99A","3soaA-1sg9A:undetectable","3soaA-1sg9A:22.81"],["4A81_A_DXCA1161_0","MAJOR POLLEN ALLERGEN BET V 1-A","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"GLY A 225;ASP A 224;ILE A 258;VAL A 259;MET A 245","None","1.15A","4a81A-1sg9A:undetectable","4a81A-1sg9A:21.02"],["4DCM_A_SAMA401_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE G","1sg9","HEMK PROTEIN","Thermotoga maritima",8,"PHE A 100;ASP A 127;GLY A 129;GLY A 131;ILE A 135;ASP A 151;ASN A 197;PRO A 199","SAM A 301 ( 3.4A);SAM A 301 ( 4.9A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 (-4.8A);SAM A 301 (-2.9A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A)","0.57A","4dcmA-1sg9A:17.2","4dcmA-1sg9A:22.83"],["4EAT_A_BEZA1000_0","BENZOATE-COENZYME A LIGASE","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"ALA A 156;ALA A 149;ILE A 128;GLY A 129","SAM A 301 ( 4.7A);None;None;SAM A 301 (-3.3A)","0.59A","4eatA-1sg9A:2.4","4eatA-1sg9A:21.32"],["4GC9_A_SAMA401_0","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"GLY A 129;GLY A 131;ILE A 135;ASN A 197;PRO A 199","SAM A 301 (-3.3A);SAM A 301 ( 3.8A);SAM A 301 (-4.8A);GLN A 400 ( 3.1A);SAM A 301 ( 4.6A)","0.50A","4gc9A-1sg9A:9.7","4gc9A-1sg9A:21.73"],["4MGH_A_ACTA1320_0","PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"VAL A  40;LEU A  51;ILE A  14;LEU A  17","None","0.84A","4mghA-1sg9A:undetectable","4mghA-1sg9A:12.47"],["4XV2_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"GLY A 136;LEU A 181;PHE A 188;ILE A 194","None","0.84A","4xv2A-1sg9A:undetectable","4xv2A-1sg9A:23.12"],["4ZBR_A_ACTA608_0","SERUM ALBUMIN","1sg9","HEMK PROTEIN","Thermotoga maritima",3,"LYS A 162;ARG A 166;HIS A 167","None","1.25A","4zbrA-1sg9A:2.8","4zbrA-1sg9A:18.76"],["4ZJZ_B_BEZB601_0","BENZOATE-COENZYME A LIGASE","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"ALA A 160;VAL A 175;PHE A 173;GLY A 133;ALA A 134","None;None;None;None;SAM A 301 ( 4.0A)","1.36A","4zjzB-1sg9A:3.2","4zjzB-1sg9A:21.32"],["5X7P_B_ACRB1421_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1sg9","HEMK PROTEIN","Thermotoga maritima",4,"GLU A 246;TYR A 200;GLY A 225;GLY A 222","GLN A 400 ( 4.8A);GLN A 400 (-3.2A);None;None","0.74A","5x7pB-1sg9A:undetectable","5x7pB-1sg9A:12.64"],["6NQA_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"ASP A 127;GLY A 129;GLY A 131;ASN A 197;PHE A 228","SAM A 301 ( 4.9A);SAM A 301 (-3.3A);SAM A 301 ( 3.8A);GLN A 400 ( 3.1A);None","1.12A","6nqaK-1sg9A:8.0","6nqaK-1sg9A:23.31"],["6NQA_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","1sg9","HEMK PROTEIN","Thermotoga maritima",5,"THR A 106;ASP A 127;GLY A 129;ASN A 197;PHE A 228","SAM A 301 (-3.4A);SAM A 301 ( 4.9A);SAM A 301 (-3.3A);GLN A 400 ( 3.1A);None","1.48A","6nqaK-1sg9A:8.0","6nqaK-1sg9A:23.31"]]