SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sgf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 8 HIS G  57
ASP G 189
SER G 195
GLY G 216
GLY G 226
None
0.74A 1aq7A-1sgfG:
35.9
1aq7A-1sgfG:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 9 ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
None
0.33A 1bcuH-1sgfG:
17.3
1bcuH-1sgfG:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 9 HIS G  57
ASP G 189
SER G 195
TRP G 215
GLY G 226
None
0.49A 1dwcH-1sgfG:
32.6
1dwcH-1sgfG:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 HIS G  57
ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
None
0.70A 1etrH-1sgfG:
32.2
1etrH-1sgfG:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 8 ASP G 189
SER G 195
GLY G 216
GLY G 226
None
0.52A 1f5lA-1sgfG:
13.2
1f5lA-1sgfG:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 10 SER G 195
SER G 214
ILE G 212
GLY G 211
GLY G 226
None
1.29A 1mehA-1sgfG:
undetectable
1mehA-1sgfG:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 8 SER A  95
GLN A  95
ASN A  95
ASP A  97
NAG  A  11 (-3.4A)
None
NAG  A  11 (-2.0A)
NAG  A  11 (-4.2A)
1.36A 1p6kA-1sgfA:
0.0
1p6kA-1sgfA:
17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 6 ASP G 189
SER G 195
GLY G 216
GLY G 226
None
0.45A 1tnlA-1sgfG:
36.7
1tnlA-1sgfG:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 8 SER A  95
GLN A  95
ASN A  95
ASP A  97
NAG  A  11 (-3.4A)
None
NAG  A  11 (-2.0A)
NAG  A  11 (-4.2A)
1.33A 1zzqA-1sgfA:
undetectable
1zzqA-1sgfA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 6 ASP G 189
SER G 195
GLY G 216
GLY G 226
None
0.33A 2otvA-1sgfG:
36.8
2otvA-1sgfG:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
TYR G 228
None
0.46A 2p16A-1sgfG:
16.8
2p16A-1sgfG:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 TYR G  99
ASP G 189
TRP G 215
GLY G 216
GLY G 226
TYR G 228
None
0.78A 2p16A-1sgfG:
16.8
2p16A-1sgfG:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 8 ASP G 189
SER G 195
GLY G 216
GLY G 226
None
0.59A 2vinA-1sgfG:
13.8
2vinA-1sgfG:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
TYR G 228
None
0.45A 2w26A-1sgfG:
17.6
2w26A-1sgfG:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 TYR G  99
ASP G 189
TRP G 215
GLY G 216
GLY G 226
TYR G 228
None
0.78A 2w26A-1sgfG:
17.6
2w26A-1sgfG:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 11 ALA G 138
GLY G 196
GLY G 140
ILE G  16
HIS G  30
None
0.96A 2x1lA-1sgfG:
undetectable
2x1lA-1sgfG:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 ALA G 138
GLY G 196
GLY G 140
ILE G  16
HIS G  30
None
0.93A 2x1lB-1sgfG:
undetectable
2x1lB-1sgfG:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 11 ALA G 138
GLY G 196
GLY G 140
ILE G  16
HIS G  30
None
0.96A 2x1lC-1sgfG:
undetectable
2x1lC-1sgfG:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 6 TRP G 141
SER G 139
ALA G 138
ASP G 194
None
1.17A 3aruA-1sgfG:
undetectable
3aruA-1sgfG:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 11 HIS G  57
ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
None
0.56A 3gy3A-1sgfG:
35.5
3gy3A-1sgfG:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 8 TYR G  40
VAL G  66
TRP G  67
GLY G  44
None
0.70A 3hjoA-1sgfG:
undetectable
3hjoA-1sgfG:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
None
0.85A 3keeA-1sgfG:
11.3
3keeA-1sgfG:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
None
0.84A 3keeB-1sgfG:
11.6
3keeB-1sgfG:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
None
0.86A 3keeC-1sgfG:
11.0
3keeC-1sgfG:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
None
0.82A 3keeD-1sgfG:
11.4
3keeD-1sgfG:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 7 TYR G  40
VAL G  66
TRP G  67
GLY G  44
None
0.70A 3kmoB-1sgfG:
undetectable
3kmoB-1sgfG:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
3 / 4 SER G  26
GLY G  19
GLU G 185
None
0.47A 3raeA-1sgfG:
undetectable
3raeC-1sgfG:
undetectable
3raeA-1sgfG:
17.54
3raeC-1sgfG:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 6 SER G 195
TRP G 215
GLY G 216
GLY G 226
None
0.39A 3rxfA-1sgfG:
15.4
3rxfA-1sgfG:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
None
0.79A 3sueA-1sgfG:
10.3
3sueA-1sgfG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
None
0.87A 3sufA-1sgfG:
10.6
3sufA-1sgfG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 GLY G  69
LEU G  73
ASN G  71
ALA G 112
LEU G  46
None
1.21A 3vywD-1sgfG:
undetectable
3vywD-1sgfG:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
4 / 5 GLU A 173
GLY A 216
TYR A  99
ASP A 102
None
1.38A 3w9tD-1sgfA:
0.0
3w9tD-1sgfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 GLY G 142
GLY G  44
GLY G 196
GLY G 193
THR G  54
VAL G  52
None
1.38A 4ctkC-1sgfG:
undetectable
4ctkC-1sgfG:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
3 / 3 LYS A  39
TYR A  40
ARG A  35
None
1.25A 4gc9A-1sgfA:
undetectable
4gc9A-1sgfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
3 / 4 SER G  26
GLY G  19
GLU G 185
None
0.41A 4juoA-1sgfG:
undetectable
4juoC-1sgfG:
undetectable
4juoA-1sgfG:
17.54
4juoC-1sgfG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 ALA A 179
SER A 236
ILE A 238
LEU A  53
THR A 177
None
1.08A 4ky8C-1sgfA:
undetectable
4ky8C-1sgfA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 12 SER A 195
ALA A  55
ASP A 102
GLU A 218
THR A 229
None
1.06A 4xt8A-1sgfA:
undetectable
4xt8A-1sgfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 GLY G 142
GLY G  44
GLY G 196
GLY G 193
THR G  54
VAL G  52
None
1.38A 5eiwC-1sgfG:
undetectable
5eiwC-1sgfG:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 GLY G 142
GLY G  44
GLY G 196
GLY G 193
THR G  54
VAL G  52
None
1.39A 5ekxB-1sgfG:
undetectable
5ekxB-1sgfG:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
6 / 12 GLY G 142
GLY G  44
GLY G 196
GLY G 193
THR G  54
VAL G  52
None
1.39A 5m5bA-1sgfG:
undetectable
5m5bA-1sgfG:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
3 / 3 SER A 214
SER A 195
PHE A  94
None
0.91A 5mugA-1sgfA:
undetectable
5mugA-1sgfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
3 / 3 SER G 214
SER G 195
PHE G  94
None
0.71A 5mugA-1sgfG:
undetectable
5mugA-1sgfG:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
5 / 7 GLY A  44
LEU A 181
ILE A 121
LEU A  47
ILE A 232
None
1.34A 5vkqA-1sgfA:
undetectable
5vkqB-1sgfA:
undetectable
5vkqA-1sgfA:
9.27
5vkqB-1sgfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
1sgf NERVE GROWTH FACTOR
(Mus
musculus)
3 / 3 GLN A  41
TRP A  67
VAL A  66
None
1.16A 6auuA-1sgfA:
undetectable
6auuA-1sgfA:
18.01