SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		5 / 12 VAL A 134
GLY A 131
LEU A 160
PHE A 151
GLU A 170
 None
 1.43A 1a27A-1sgjA:
undetectable		 1a27A-1sgjA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 8 ALA A 182
LEU A 180
LEU A 169
LEU A 172
 None
 0.91A 1dvtA-1sgjA:
undetectable
1dvtB-1sgjA:
undetectable		 1dvtA-1sgjA:
18.09
1dvtB-1sgjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 7 ARG A  74
VAL A  98
ASN A  76
ASP A  39
 OAA  A 285 ( 2.3A)
None
None
OAA  A 285 (-4.6A)
 1.34A 1hwiC-1sgjA:
undetectable		 1hwiC-1sgjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 7 ARG A  74
VAL A  98
ASN A  76
ASP A  39
 OAA  A 285 ( 2.3A)
None
None
OAA  A 285 (-4.6A)
 1.35A 1hwiD-1sgjA:
undetectable		 1hwiD-1sgjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		5 / 8 LEU A 102
ALA A 126
GLY A 133
GLY A 152
ASP A 155
 None
None
None
OAA  A 285 ( 4.8A)
MG  A 286 ( 4.6A)
 1.35A 2yfxA-1sgjA:
undetectable		 2yfxA-1sgjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		3 / 3 LEU A  25
ARG A  74
ASN A  17
 None
OAA  A 285 ( 2.3A)
None
 0.71A 3qxvD-1sgjA:
undetectable		 3qxvD-1sgjA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		5 / 12 TYR A 156
GLY A 133
GLY A 131
LEU A 160
PHE A 151
 None
 1.17A 3vywA-1sgjA:
2.4		 3vywA-1sgjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		5 / 12 TYR A 156
GLY A 133
GLY A 131
LEU A 160
PHE A 151
 None
 1.22A 3vywB-1sgjA:
undetectable		 3vywB-1sgjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 4 LEU A 190
SER A  10
LEU A   7
LEU A 125
 None
 0.94A 4n09A-1sgjA:
2.6		 4n09A-1sgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 5 LEU A 190
SER A  10
LEU A   7
LEU A 125
 None
 0.93A 4n09B-1sgjA:
2.5		 4n09B-1sgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 5 LEU A 190
SER A  10
LEU A   7
LEU A 125
 None
 0.95A 4n09D-1sgjA:
2.7		 4n09D-1sgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		3 / 3 GLU A 201
TYR A 232
GLU A 208
 None
 0.71A 4ryaA-1sgjA:
undetectable		 4ryaA-1sgjA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 7 ILE A  35
GLY A  16
ASP A  86
PHE A  83
 None
 0.84A 5hieB-1sgjA:
undetectable		 5hieB-1sgjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		4 / 8 ILE A  35
GLY A  16
ASP A  86
PHE A  83
 None
 0.86A 5hieD-1sgjA:
undetectable		 5hieD-1sgjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1sgj CITRATE LYASE, BETA
SUBUNIT
(Deinococcus
radiodurans) 		5 / 12 LEU A 128
GLY A 105
ASN A 136
ALA A 181
VAL A 146
 None
 1.20A 5kbwB-1sgjA:
undetectable		 5kbwB-1sgjA:
22.97