SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1sgl TRICHOMAGLIN
(Trichosanthes
lepiniana) 		3 / 3 GLN A  39
LYS A 134
VAL A 132
 None
 0.83A 2jfaB-1sglA:
undetectable		 2jfaB-1sglA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 1sgl TRICHOMAGLIN
(Trichosanthes
lepiniana) 		3 / 3 GLU A  95
GLY A  99
SER A  89
 None
 0.71A 4b53B-1sglA:
undetectable		 4b53B-1sglA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 1sgl TRICHOMAGLIN
(Trichosanthes
lepiniana) 		5 / 12 GLY A 174
VAL A 176
LEU A 151
SER A 197
VAL A 195
 None
 1.24A 4f84A-1sglA:
undetectable		 4f84A-1sglA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1sgl TRICHOMAGLIN
(Trichosanthes
lepiniana) 		3 / 3 SER A  18
TYR A  82
PRO A 205
 None
 0.98A 4kahB-1sglA:
undetectable		 4kahB-1sglA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1sgl TRICHOMAGLIN
(Trichosanthes
lepiniana) 		3 / 3 SER A  18
TYR A  82
PRO A 205
 None
 0.94A 4kbeB-1sglA:
undetectable		 4kbeB-1sglA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sgl TRICHOMAGLIN
(Trichosanthes
lepiniana) 		4 / 4 LEU A 126
TYR A 102
PRO A  47
ILE A   9
 None
None
None
SO4  A 253 ( 4.8A)
 1.03A 5esgA-1sglA:
undetectable		 5esgA-1sglA:
19.01