SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		5 / 11 ILE E  16
ASN E  78
ARG E 139
SER E 141
GLY E  19
 None
 1.27A 1ho5A-1sgqE:
undetectable		 1ho5A-1sgqE:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		4 / 7 ILE E 124
GLY E 117
PRO E 198
ASN E  47
 None
 0.97A 1oniG-1sgqE:
undetectable
1oniI-1sgqE:
undetectable		 1oniG-1sgqE:
20.94
1oniI-1sgqE:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		3 / 3 PRO E  99
ASP E 102
ASP E  60
 None
 0.80A 1sqfA-1sgqE:
undetectable		 1sqfA-1sgqE:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		5 / 12 GLY E 196
GLY E 140
GLN E 229
ASP E 102
SER E 214
 None
 1.19A 1wg8A-1sgqE:
undetectable		 1wg8A-1sgqE:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		4 / 6 LEU E  85
TYR E 108
ILE E 113
GLY E  18
 None
 0.92A 2du8A-1sgqE:
undetectable		 2du8A-1sgqE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		4 / 6 LEU E  85
TYR E 108
ILE E 113
GLY E  18
 None
 0.92A 2du8B-1sgqE:
undetectable		 2du8B-1sgqE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		5 / 12 ILE E 124
ALA E 127
LEU E 235
LEU E 212
LEU E  44
 None
 1.16A 3ix9A-1sgqE:
undetectable		 3ix9A-1sgqE:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		6 / 12 ASP E  60
ASP E 102
GLY E 197
GLY E 193
ASP E 175
ILE E  31
 None
 1.30A 3prsA-1sgqE:
undetectable		 3prsA-1sgqE:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		4 / 5 THR E 157
GLY E 140
PRO E 198
TYR E 200
 None
 1.09A 3u8qA-1sgqE:
undetectable		 3u8qA-1sgqE:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		3 / 3 SER E  43
ASP E 102
ASP E 175
 None
 0.90A 3uj7A-1sgqE:
undetectable		 3uj7A-1sgqE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		3 / 3 ASP E 102
TRP E  66
SER E 195
 None
 1.01A 4lrhB-1sgqE:
undetectable		 4lrhB-1sgqE:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		3 / 3 ASP E 102
TRP E  66
SER E 195
 None
 1.10A 4lrhF-1sgqE:
0.0		 4lrhF-1sgqE:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		5 / 12 ALA E 192
ILE E 113
PHE E  52
GLY E  86
THR E  65
 None
 1.19A 5eshA-1sgqE:
undetectable		 5eshA-1sgqE:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		5 / 10 ILE E  31
GLY E 104
SER E 195
GLY E 197
VAL E 106
 None
 1.13A 5i6xA-1sgqE:
undetectable		 5i6xA-1sgqE:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1sgq STREPTOMYCES GRISEUS
PROTEINASE B
(Streptomyces
griseus) 		5 / 12 GLY E 193
GLY E 223
THR E 157
GLY E 156
GLY E 140
 None
 0.90A 5koxA-1sgqE:
undetectable		 5koxA-1sgqE:
18.98