SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.10A 1a52B-1sgvA:
undetectable		 1a52B-1sgvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.19A 1ereA-1sgvA:
undetectable		 1ereA-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.13A 1ereA-1sgvA:
undetectable		 1ereA-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.17A 1ereB-1sgvA:
undetectable		 1ereB-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.11A 1ereB-1sgvA:
undetectable		 1ereB-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.18A 1ereC-1sgvA:
undetectable		 1ereC-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.12A 1ereC-1sgvA:
undetectable		 1ereC-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.17A 1ereD-1sgvA:
undetectable		 1ereD-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.10A 1ereD-1sgvA:
undetectable		 1ereD-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.18A 1ereE-1sgvA:
undetectable		 1ereE-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.19A 1ereF-1sgvA:
undetectable		 1ereF-1sgvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 239
LEU A 241
GLU A 245
ALA A 248
PRO A 256
 None
 1.45A 1mjoA-1sgvA:
undetectable		 1mjoA-1sgvA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 239
LEU A 241
GLU A 245
ALA A 248
PRO A 256
 None
 1.47A 1mjoB-1sgvA:
undetectable		 1mjoB-1sgvA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 239
LEU A 241
GLU A 245
ALA A 248
PRO A 256
 None
 1.47A 1mjoC-1sgvA:
undetectable		 1mjoC-1sgvA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.13A 1pcgA-1sgvA:
undetectable		 1pcgA-1sgvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.08A 1pcgA-1sgvA:
undetectable		 1pcgA-1sgvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.13A 1pcgB-1sgvA:
undetectable		 1pcgB-1sgvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.09A 1qkuA-1sgvA:
undetectable		 1qkuA-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.13A 1qkuA-1sgvA:
undetectable		 1qkuA-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.10A 1qkuB-1sgvA:
undetectable		 1qkuB-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.13A 1qkuB-1sgvA:
undetectable		 1qkuB-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.09A 1qkuC-1sgvA:
undetectable		 1qkuC-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.13A 1qkuC-1sgvA:
undetectable		 1qkuC-1sgvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		4 / 7 THR A   4
LEU A 224
VAL A   9
ILE A  29
 None
 0.98A 1t87B-1sgvA:
undetectable		 1t87B-1sgvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 268
PRO A 292
ALA A 250
ILE A 274
 None
 1.04A 2aofB-1sgvA:
undetectable		 2aofB-1sgvA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 291
LEU A 290
ILE A  59
LEU A  63
GLY A  52
 None
 1.26A 2bxmA-1sgvA:
undetectable		 2bxmA-1sgvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ILE A   8
ILE A  51
ALA A 223
LEU A 224
SER A 225
 None
 1.09A 2h79A-1sgvA:
undetectable		 2h79A-1sgvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 231
GLU A 230
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.11A 2jfaA-1sgvA:
undetectable		 2jfaA-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 231
GLU A 230
LEU A 234
LEU A 226
LEU A 224
LEU A  63
 None
 1.15A 2jfaA-1sgvA:
undetectable		 2jfaA-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 231
GLU A 230
LEU A 234
LEU A 226
LEU A 224
LEU A  63
 None
 1.15A 2jfaB-1sgvA:
undetectable		 2jfaB-1sgvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.11A 2yjaB-1sgvA:
undetectable		 2yjaB-1sgvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.07A 2yjaB-1sgvA:
undetectable		 2yjaB-1sgvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.12A 3olsB-1sgvA:
undetectable		 3olsB-1sgvA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.09A 3q95A-1sgvA:
undetectable		 3q95A-1sgvA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.15A 3uudA-1sgvA:
undetectable		 3uudA-1sgvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.15A 3uudB-1sgvA:
0.0		 3uudB-1sgvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 191
GLY A 193
GLY A 187
LEU A 186
GLY A  77
 None
 0.87A 4o3fA-1sgvA:
undetectable		 4o3fA-1sgvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  48
LEU A 224
SER A 225
LEU A 218
PHE A  30
 None
 1.46A 4qdcA-1sgvA:
0.0		 4qdcA-1sgvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 279
THR A 242
ALA A 246
ALA A 248
TYR A 264
 None
 1.48A 4u14A-1sgvA:
undetectable		 4u14A-1sgvA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 THR A  32
GLY A   7
GLY A   5
ALA A 231
ALA A  56
 None
 0.76A 4uciA-1sgvA:
undetectable		 4uciA-1sgvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 THR A  32
GLY A   7
GLY A   5
ALA A 231
ALA A  56
 None
 0.75A 4uciB-1sgvA:
undetectable		 4uciB-1sgvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 THR A  32
GLY A   7
GLY A   5
ALA A 231
ALA A  56
 None
 0.76A 4uckA-1sgvA:
undetectable		 4uckA-1sgvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.12A 5dxbB-1sgvA:
undetectable		 5dxbB-1sgvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.09A 5dxbB-1sgvA:
undetectable		 5dxbB-1sgvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.12A 5dxeB-1sgvA:
undetectable		 5dxeB-1sgvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.14A 5dxgB-1sgvA:
0.0		 5dxgB-1sgvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 255
LEU A 241
VAL A 263
ARG A 239
ALA A 266
 None
 1.19A 5g44A-1sgvA:
0.0		 5g44A-1sgvA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.04A 5gtrA-1sgvA:
undetectable		 5gtrA-1sgvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.14A 5gtrA-1sgvA:
undetectable		 5gtrA-1sgvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		4 / 4 CYH A 232
LEU A 290
LEU A 276
ALA A 288
 None
 0.86A 5hpuA-1sgvA:
undetectable
5hpuB-1sgvA:
undetectable		 5hpuA-1sgvA:
5.71
5hpuB-1sgvA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.16A 5hyrA-1sgvA:
undetectable		 5hyrA-1sgvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 230
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.16A 5toaB-1sgvA:
undetectable		 5toaB-1sgvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.18A 5wgdA-1sgvA:
undetectable		 5wgdA-1sgvA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1sgv TRNA PSEUDOURIDINE
SYNTHASE B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.09A 5wgqB-1sgvA:
0.0		 5wgqB-1sgvA:
12.89