SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		4 / 5 THR A  41
ASP A 150
PRO A  76
SER A  48
 None
 1.42A 2hdnA-1sgwA:
0.0
2hdnB-1sgwA:
0.1
2hdnD-1sgwA:
undetectable		 2hdnA-1sgwA:
15.00
2hdnB-1sgwA:
21.20
2hdnD-1sgwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		4 / 5 SER A  48
THR A  41
ASP A 150
PRO A  76
 None
 1.41A 2hdnB-1sgwA:
0.1
2hdnC-1sgwA:
0.0
2hdnD-1sgwA:
undetectable		 2hdnB-1sgwA:
21.20
2hdnC-1sgwA:
15.00
2hdnD-1sgwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		5 / 12 ILE A  58
ILE A  47
LEU A   3
VAL A 148
VAL A  30
 None
 1.04A 2nnhA-1sgwA:
0.0		 2nnhA-1sgwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		4 / 5 ILE A  47
ARG A   6
MET A  22
THR A  23
 None
 1.11A 3abkN-1sgwA:
undetectable
3abkW-1sgwA:
undetectable		 3abkN-1sgwA:
17.74
3abkW-1sgwA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		4 / 6 SER A 181
PHE A  32
ILE A  47
PHE A  73
 None
 1.03A 3ko0S-1sgwA:
0.6		 3ko0S-1sgwA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		3 / 3 GLY A  37
GLY A  39
THR A  41
 CL  A 207 (-3.7A)
CL  A 207 (-4.0A)
None
 0.43A 3si7B-1sgwA:
17.5		 3si7B-1sgwA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		5 / 10 ILE A  85
LEU A 123
VAL A 116
ILE A 107
LEU A 111
 None
 1.19A 5ienB-1sgwA:
0.0		 5ienB-1sgwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		5 / 10 ILE A  20
ILE A   5
VAL A  10
THR A  46
ILE A  47
 None
 1.46A 5mzrA-1sgwA:
undetectable		 5mzrA-1sgwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		5 / 10 ILE A  20
ILE A   5
VAL A  10
THR A  46
ILE A  47
 None
 1.49A 5mzrC-1sgwA:
undetectable		 5mzrC-1sgwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1sgw PUTATIVE ABC
TRANSPORTER
(Pyrococcus
furiosus) 		5 / 9 ILE A  20
ILE A   5
VAL A  10
THR A  46
ILE A  47
 None
 1.49A 5mzrD-1sgwA:
0.0		 5mzrD-1sgwA:
21.98