SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 11 ILE A  91
LEU A 202
ILE A  98
ILE A 215
ILE A  90
 None
 1.02A 1dyrA-1sh2A:
undetectable		 1dyrA-1sh2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 ILE A 463
LEU A 444
LEU A 440
TYR A 455
ILE A 458
 None
 1.16A 1fmlB-1sh2A:
undetectable		 1fmlB-1sh2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 8 PRO A 214
HIS A 313
SER A 310
GLU A 345
 None
 1.07A 1jtvA-1sh2A:
undetectable		 1jtvA-1sh2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 LEU A 140
LEU A 113
ALA A 198
ALA A 196
GLN A 143
 None
 1.32A 1kt4A-1sh2A:
0.0		 1kt4A-1sh2A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		3 / 3 LYS A  68
ILE A 294
THR A   7
 None
 0.86A 1rx3A-1sh2A:
undetectable		 1rx3A-1sh2A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 LEU A 367
LEU A 298
GLY A 297
PHE A  70
ALA A 312
 None
 1.14A 1tlsB-1sh2A:
undetectable		 1tlsB-1sh2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 LEU A 367
LEU A 298
GLY A 297
PHE A  70
ALA A 312
 None
 1.16A 1tsnA-1sh2A:
undetectable		 1tsnA-1sh2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		3 / 3 ASP A 278
VAL A 160
PRO A 122
 None
 0.77A 2avvA-1sh2A:
undetectable		 2avvA-1sh2A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 8 LEU A 379
GLU A 345
HIS A 313
ALA A 241
 None
 0.98A 2bnnA-1sh2A:
undetectable
2bnnB-1sh2A:
undetectable		 2bnnA-1sh2A:
18.40
2bnnB-1sh2A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 6 LEU A 279
ALA A 198
ASP A 188
TYR A 161
 None
 1.34A 2dpzA-1sh2A:
undetectable		 2dpzA-1sh2A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 GLY A 163
GLY A 120
LEU A 165
ASP A 286
VAL A 287
 None
 1.04A 2oxtA-1sh2A:
undetectable		 2oxtA-1sh2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 GLY A 163
GLY A 120
LEU A 165
ASP A 286
VAL A 287
 None
 1.04A 2oxtC-1sh2A:
undetectable		 2oxtC-1sh2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		3 / 3 LEU A 318
LEU A  94
PHE A 338
 None
 0.67A 2pgrA-1sh2A:
undetectable		 2pgrA-1sh2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 ILE A 215
LEU A 213
ILE A 261
ALA A 258
LEU A 202
 None
 1.07A 3a50D-1sh2A:
0.0		 3a50D-1sh2A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		3 / 3 GLY A 377
PRO A 369
LEU A 379
 None
 0.64A 3hcpB-1sh2A:
undetectable		 3hcpB-1sh2A:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 5 ARG A 182
ASP A 242
ASP A 343
ASP A 344
ARG A 392
 None
 1.06A 3naiA-1sh2A:
50.3		 3naiA-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 4 ARG A 182
ASP A 242
ASP A 343
ASP A 344
 None
 0.94A 3naiB-1sh2A:
50.4		 3naiB-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 5 ARG A 182
ASP A 242
ASP A 344
ARG A 392
 None
 0.91A 3naiC-1sh2A:
50.7		 3naiC-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 5 ARG A 182
ASP A 343
ASP A 344
ARG A 392
 None
 0.44A 3naiC-1sh2A:
50.7		 3naiC-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		7 / 9 ASP A 247
SER A 300
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
 None
 0.86A 3sfuA-1sh2A:
49.0		 3sfuA-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 9 SER A 300
THR A 305
TYR A 341
GLY A 342
ASP A 344
 None
 0.84A 3sfuA-1sh2A:
49.0		 3sfuA-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		7 / 9 ASP A 247
ASN A 309
GLY A 342
ASP A 343
ASP A 344
LEU A 391
ARG A 392
 None
 0.79A 3sfuB-1sh2A:
49.7		 3sfuB-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		7 / 9 ASP A 247
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
LEU A 391
 None
 0.43A 3sfuB-1sh2A:
49.7		 3sfuB-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		6 / 11 ASP A 247
LEU A 298
THR A 305
ASN A 309
GLY A 342
ASP A 343
 None
 0.73A 3sfuC-1sh2A:
49.1		 3sfuC-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		6 / 11 LEU A 298
SER A 300
THR A 305
ASN A 309
GLY A 342
ASP A 343
 None
 0.89A 3sfuC-1sh2A:
49.1		 3sfuC-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		8 / 11 LYS A 166
ARG A 182
LEU A 184
ASP A 247
LEU A 298
ASN A 309
GLY A 342
ASP A 343
 None
 0.48A 3sfuC-1sh2A:
49.1		 3sfuC-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_C_SVRC517_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		6 / 11 GLN A  66
GLU A 168
VAL A 170
LYS A 180
ARG A 182
ARG A 245
 None
 0.64A 3ur0C-1sh2A:
50.0		 3ur0C-1sh2A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_C_SVRC517_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 11 GLN A  66
VAL A 170
LYS A 174
LYS A 180
ARG A 245
 None
 1.02A 3ur0C-1sh2A:
50.0		 3ur0C-1sh2A:
57.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		3 / 3 LYS A  68
ILE A 294
THR A   7
 None
 0.86A 4gh8A-1sh2A:
undetectable		 4gh8A-1sh2A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 5 PRO A 372
GLU A 407
ARG A 393
THR A 389
 None
 1.34A 5uxcA-1sh2A:
undetectable		 5uxcA-1sh2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		5 / 12 LEU A  22
GLY A  17
PRO A  20
THR A 291
VAL A 284
 None
 1.30A 5x6yA-1sh2A:
undetectable		 5x6yA-1sh2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 1sh2 RNA POLYMERASE
(Norwalk
virus) 		4 / 8 PHE A  70
VAL A 285
SER A 283
TYR A 161
 None
 1.25A 6huoC-1sh2A:
undetectable
6huoD-1sh2A:
undetectable		 6huoC-1sh2A:
9.82
6huoD-1sh2A:
13.60