SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  99
GLY A  64
ALA A  65
THR A  12
LEU A  24
 None
 1.14A 1nr6A-1sh8A:
undetectable		 1nr6A-1sh8A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  94
ARG A  96
ARG A  37
 None
 0.65A 2j9dA-1sh8A:
0.0
2j9dC-1sh8A:
0.0		 2j9dA-1sh8A:
23.23
2j9dC-1sh8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  53
ALA A  54
LEU A  58
LEU A  61
LEU A  36
 None
 0.95A 4o1zA-1sh8A:
undetectable		 4o1zA-1sh8A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 123
VAL A  34
VAL A  97
LEU A 101
 None
 1.10A 4pwdC-1sh8A:
undetectable		 4pwdC-1sh8A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  99
GLY A  64
ALA A  65
THR A  12
 None
 0.85A 4r1zB-1sh8A:
undetectable		 4r1zB-1sh8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		5 / 12 THR A   5
LEU A   7
ALA A   8
LEU A  68
GLY A  32
 None
 1.00A 4xi3C-1sh8A:
undetectable		 4xi3C-1sh8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		5 / 11 ALA A  99
GLY A  32
LEU A  58
LEU A  61
THR A  12
 None
 1.07A 4zmeA-1sh8A:
undetectable		 4zmeA-1sh8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		4 / 6 PRO A  62
GLY A  63
LEU A 101
VAL A  34
 None
 0.95A 5x80A-1sh8A:
undetectable
5x80B-1sh8A:
undetectable		 5x80A-1sh8A:
28.49
5x80B-1sh8A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1sh8 HYPOTHETICAL PROTEIN
PA5026
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  33
THR A  84
LEU A  66
LEU A  36
VAL A  97
 None
 1.37A 6a93B-1sh8A:
undetectable		 6a93B-1sh8A:
18.70