SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1shc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1shc SHC
(Homo
sapiens) 		4 / 8 VAL A 164
TYR A 166
GLY A 155
LEU A 124
 None
 0.83A 1jlbA-1shcA:
undetectable		 1jlbA-1shcA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1shc SHC
(Homo
sapiens) 		4 / 7 THR A  78
ASN A  72
LEU A 106
GLN A  76
 None
 0.90A 1qzrA-1shcA:
undetectable		 1qzrA-1shcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1shc SHC
(Homo
sapiens) 		4 / 7 THR A  78
ASN A  72
LEU A 106
GLN A  76
 None
 0.89A 1qzrB-1shcA:
undetectable		 1qzrB-1shcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1shc SHC
(Homo
sapiens) 		5 / 12 VAL A 167
ALA A 165
ILE A  82
ASP A 159
LEU A 110
 None
 1.09A 2w3vA-1shcA:
undetectable		 2w3vA-1shcA:
25.93