SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1shx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_2 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	1shx	EPHRIN-A5 (Mus musculus)	4 / 8	VAL A 38 VAL A 163 VAL A 161 LEU A 62	None	0.90A	1igxA-1shxA: undetectable	1igxA-1shxA: 12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SV5_A_65BA600_0 (REVERSE TRANSCRIPTASE)	1shx	EPHRIN-A5 (Mus musculus)	5 / 10	LEU A 159 LYS A 160 VAL A 56 LEU A 62 TYR A 142	None	1.39A	1sv5A-1shxA: undetectable	1sv5A-1shxA: 12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_A_FFOA505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1shx	EPHRIN-A5 (Mus musculus)	4 / 6	GLU A 120 TYR A 140 TYR A 142 PHE A 134	None	1.36A	2vmyA-1shxA: undetectable	2vmyA-1shxA: 15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YFB_A_ACTA501_0 (METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER)	1shx	EPHRIN-A5 (Mus musculus)	4 / 7	ARG A 138 VAL A 163 ILE A 58 TYR A 140	None	1.12A	2yfbA-1shxA: undetectable	2yfbA-1shxA: 15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YFB_B_ACTB501_0 (METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER)	1shx	EPHRIN-A5 (Mus musculus)	4 / 6	ARG A 138 VAL A 163 ILE A 58 TYR A 140	None	1.08A	2yfbB-1shxA: undetectable	2yfbB-1shxA: 15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1shx	EPHRIN-A5 (Mus musculus)	5 / 9	LEU A 159 LYS A 160 VAL A 56 LEU A 62 TYR A 142	None	1.27A	4b3oA-1shxA: undetectable	4b3oA-1shxA: 12.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IGX_A_EPAA700_2","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","1shx","EPHRIN-A5","Mus musculus",4,"VAL A  38;VAL A 163;VAL A 161;LEU A  62","None","0.90A","1igxA-1shxA:undetectable","1igxA-1shxA:12.57"],["1SV5_A_65BA600_0","REVERSE TRANSCRIPTASE","1shx","EPHRIN-A5","Mus musculus",5,"LEU A 159;LYS A 160;VAL A  56;LEU A  62;TYR A 142","None","1.39A","1sv5A-1shxA:undetectable","1sv5A-1shxA:12.77"],["2VMY_A_FFOA505_0","SERINE HYDROXYMETHYLTRANSFERASE","1shx","EPHRIN-A5","Mus musculus",4,"GLU A 120;TYR A 140;TYR A 142;PHE A 134","None","1.36A","2vmyA-1shxA:undetectable","2vmyA-1shxA:15.01"],["2YFB_A_ACTA501_0","METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER","1shx","EPHRIN-A5","Mus musculus",4,"ARG A 138;VAL A 163;ILE A  58;TYR A 140","None","1.12A","2yfbA-1shxA:undetectable","2yfbA-1shxA:15.50"],["2YFB_B_ACTB501_0","METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER","1shx","EPHRIN-A5","Mus musculus",4,"ARG A 138;VAL A 163;ILE A  58;TYR A 140","None","1.08A","2yfbB-1shxA:undetectable","2yfbB-1shxA:15.50"],["4B3O_A_EFZA1557_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1shx","EPHRIN-A5","Mus musculus",5,"LEU A 159;LYS A 160;VAL A  56;LEU A  62;TYR A 142","None","1.27A","4b3oA-1shxA:undetectable","4b3oA-1shxA:12.41"]]