SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1shz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 LEU C  76
MET C  60
LEU C  59
GLN C 153
 None
 1.48A 1p93D-1shzC:
undetectable		 1p93D-1shzC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		4 / 5 LEU A 152
ASP A 155
VAL A 100
ILE A 158
 None
 0.91A 2aoiB-1shzA:
undetectable		 2aoiB-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
ASN A 160
ILE A 158
 None
 0.90A 2f80B-1shzA:
undetectable		 2f80B-1shzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 11 ILE A 206
GLY A 225
GLU A 229
LEU A  52
GLY A 205
 None
ALF  A 378 (-3.2A)
None
None
None
 1.17A 2fn1A-1shzA:
undetectable		 2fn1A-1shzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
ASN A 160
ILE A 158
 None
 0.91A 2pymA-1shzA:
undetectable		 2pymA-1shzA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.97A 2pymA-1shzA:
undetectable		 2pymA-1shzA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.96A 2pymB-1shzA:
undetectable		 2pymB-1shzA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
ASN A 160
ILE A 158
 None
 0.92A 2pynA-1shzA:
undetectable		 2pynA-1shzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.96A 2pynA-1shzA:
undetectable		 2pynA-1shzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
ASN A 160
ILE A 158
 None
 0.93A 2pynB-1shzA:
undetectable		 2pynB-1shzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.96A 2pynB-1shzA:
undetectable		 2pynB-1shzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.99A 2q63B-1shzA:
undetectable		 2q63B-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
ASN A 160
ILE A 158
 None
 0.91A 2q64A-1shzA:
undetectable		 2q64A-1shzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		6 / 12 LEU A 152
ASP A 155
GLY A 111
ASN A 160
VAL A 100
ILE A 158
 None
 1.10A 2q64B-1shzA:
undetectable		 2q64B-1shzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
ASN A 160
ILE A 158
 None
 0.93A 2qakB-1shzA:
undetectable		 2qakB-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.90A 3cywA-1shzA:
undetectable		 3cywA-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLY C  73
GLN C 146
VAL C 112
VAL C  66
GLN C 153
 None
 1.34A 3fi0H-1shzC:
undetectable		 3fi0H-1shzC:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.97A 3k4vD-1shzA:
undetectable		 3k4vD-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.91A 3lzuB-1shzA:
undetectable		 3lzuB-1shzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.98A 3nduB-1shzA:
undetectable		 3nduB-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.99A 3nduC-1shzA:
undetectable		 3nduC-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.98A 3oxcB-1shzA:
undetectable		 3oxcB-1shzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A 152
ASP A 155
GLY A 111
VAL A 100
ILE A 158
 None
 0.97A 3tkgB-1shzA:
undetectable		 3tkgB-1shzA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 7 ALA C  57
PRO C  56
ARG C  54
ARG C 183
 None
 1.03A 3twpC-1shzC:
undetectable		 3twpC-1shzC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		6 / 12 GLY A  60
GLY A  57
GLY A 225
SER A  59
ALA A 348
THR A 349
 GDP  A 475 (-3.2A)
ALF  A 378 (-3.3A)
ALF  A 378 (-3.2A)
GDP  A 475 (-3.4A)
GDP  A 475 (-3.5A)
GDP  A 475 (-3.8A)
 1.35A 4uckA-1shzA:
undetectable		 4uckA-1shzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 TYR C 225
PHE C 103
GLY C  73
LEU C  63
LEU C  59
 None
 1.40A 4ze0A-1shzC:
undetectable		 4ze0A-1shzC:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU C  59
ALA C  57
GLU C 190
LEU C 172
LEU C 197
 None
 1.23A 4zn7A-1shzC:
undetectable		 4zn7A-1shzC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU C  76
LEU C  59
LEU C  62
MET C  83
LEU C  49
 None
 1.22A 4zn7A-1shzC:
undetectable		 4zn7A-1shzC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 THR A  87
ALA A 199
ASN A  91
 None
 0.60A 5ersA-1shzA:
2.1		 5ersA-1shzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 4 ALA C 108
PRO C  72
LEU C  79
HIS C  80
 None
 1.34A 5eskA-1shzC:
1.6		 5eskA-1shzC:
19.27