SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1si1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 12 LEU A 122
THR A 159
ASP A 120
LEU A 146
HIS A 153
 None
 1.48A 1d4fC-1si1A:
undetectable		 1d4fC-1si1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		4 / 6 ILE A 231
ARG A 101
TYR A 301
VAL A 235
 None
FE  A 321 ( 4.2A)
None
None
 1.00A 1db1A-1si1A:
0.0		 1db1A-1si1A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		4 / 7 TYR A 199
ARG A 136
ARG A 103
ASN A 140
 FE  A 321 (-4.0A)
None
None
None
 1.45A 1f9gA-1si1A:
undetectable		 1f9gA-1si1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		4 / 7 ALA A 298
ILE A  60
ILE A 231
PHE A  88
 None
 0.92A 1upfB-1si1A:
undetectable		 1upfB-1si1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		4 / 8 LYS A  44
VAL A  43
TYR A   7
LEU A  55
 None
 0.70A 1z2bB-1si1A:
undetectable		 1z2bB-1si1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 12 ILE A  32
VAL A   6
LEU A  56
VAL A  54
LEU A 253
 None
 0.75A 2aw1A-1si1A:
undetectable		 2aw1A-1si1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 8 ALA A 258
LEU A 249
ILE A  15
VAL A  54
ILE A 236
 None
 1.22A 2uxpA-1si1A:
undetectable		 2uxpA-1si1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 8 ALA A 258
LEU A 253
LEU A 249
VAL A  30
ILE A  32
 None
 1.29A 2uxpA-1si1A:
undetectable		 2uxpA-1si1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 10 ILE A 297
ILE A 292
GLY A 226
PHE A 287
LEU A 146
 None
 1.22A 3elzB-1si1A:
undetectable		 3elzB-1si1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 11 ALA A  69
GLU A  65
LEU A  39
GLY A  47
HIS A 239
 None
 1.28A 3uudA-1si1A:
undetectable		 3uudA-1si1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		4 / 7 LEU A 124
TYR A 121
LEU A 115
TYR A 129
 None
 1.11A 4b3qA-1si1A:
undetectable		 4b3qA-1si1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 10 VAL A   6
LEU A  56
VAL A  54
LEU A 253
VAL A 234
 None
 0.86A 4e3hA-1si1A:
undetectable		 4e3hA-1si1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 12 TYR A 142
GLY A 195
ASN A 196
ILE A 105
LEU A 166
 FE  A 321 (-4.3A)
None
None
None
None
 1.33A 4kovA-1si1A:
0.0		 4kovA-1si1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		3 / 3 LEU A 163
LYS A 160
THR A 159
 None
 0.60A 4lj0A-1si1A:
undetectable		 4lj0A-1si1A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		4 / 8 LEU A 253
VAL A  30
VAL A  54
TYR A 252
 None
 0.94A 4puoC-1si1A:
undetectable		 4puoC-1si1A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 12 VAL A 271
GLY A 233
ASP A  93
VAL A  54
ILE A 236
 None
 1.03A 4q5mA-1si1A:
undetectable		 4q5mA-1si1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 12 VAL A 271
GLY A 233
ILE A  84
VAL A  54
ILE A 236
 None
 0.99A 4q5mA-1si1A:
undetectable		 4q5mA-1si1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 11 GLY A 118
ILE A 194
SER A 193
TYR A 106
PRO A 221
 None
 1.46A 4rtrA-1si1A:
undetectable		 4rtrA-1si1A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		4 / 4 VAL A   4
ALA A   1
PHE A  22
THR A  26
 None
 1.49A 4z4hA-1si1A:
0.4		 4z4hA-1si1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 11 ALA A  69
GLU A  65
LEU A  39
GLY A  47
HIS A 239
 None
 1.22A 5dxbB-1si1A:
undetectable		 5dxbB-1si1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 12 ILE A 194
ALA A 303
ALA A 304
VAL A 308
GLY A 155
 None
 0.68A 5igjA-1si1A:
0.0		 5igjA-1si1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		5 / 12 ILE A 194
ALA A 303
ALA A 304
VAL A 308
TYR A 154
 None
 0.55A 5igpA-1si1A:
undetectable		 5igpA-1si1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		6 / 12 ILE A 194
ALA A 303
ALA A 304
VAL A 308
GLY A 155
TYR A 154
 None
 0.84A 5igtA-1si1A:
undetectable		 5igtA-1si1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		3 / 3 VAL A  58
TYR A   9
GLU A 268
 None
 0.87A 5zmqD-1si1A:
undetectable
5zmqE-1si1A:
undetectable		 5zmqD-1si1A:
21.77
5zmqE-1si1A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		3 / 3 ARG A  62
ARG A 136
ARG A 101
 None
None
FE  A 321 ( 4.2A)
 1.08A 6bplA-1si1A:
undetectable
6bplB-1si1A:
undetectable		 6bplA-1si1A:
14.18
6bplB-1si1A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1si1 IRON BINDING PROTEIN
FBPA
(Mannheimia
haemolytica) 		3 / 3 ARG A 179
ARG A 101
ARG A 136
 None
FE  A 321 ( 4.2A)
None
 1.10A 6bplA-1si1A:
undetectable
6bplB-1si1A:
undetectable		 6bplA-1si1A:
14.18
6bplB-1si1A:
14.18