SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1si8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.09A 1dfoA-1si8A:
undetectable		 1dfoA-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.09A 1dfoB-1si8A:
undetectable		 1dfoB-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.08A 1dfoC-1si8A:
undetectable		 1dfoC-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.09A 1dfoD-1si8A:
undetectable		 1dfoD-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.08A 1eqbA-1si8A:
undetectable		 1eqbA-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.08A 1eqbB-1si8A:
undetectable		 1eqbB-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.08A 1eqbC-1si8A:
undetectable		 1eqbC-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.08A 1eqbD-1si8A:
undetectable		 1eqbD-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 5 LEU A  88
LEU A 113
MET A 295
MET A 191
 None
 1.13A 2oaxF-1si8A:
0.0		 2oaxF-1si8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 7 ALA A 336
ALA A 340
PRO A 315
ARG A  51
 HEM  A 501 ( 3.9A)
HEM  A 501 (-3.6A)
None
HEM  A 501 (-4.0A)
 0.86A 2ql8A-1si8A:
undetectable
2ql8B-1si8A:
undetectable		 2ql8A-1si8A:
15.16
2ql8B-1si8A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 GLN A 147
PHE A 143
ARG A 135
ILE A 134
PHE A 164
 None
 1.32A 2vdyB-1si8A:
0.0		 2vdyB-1si8A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 11 LEU A 113
LYS A 114
LEU A  88
LEU A 124
THR A 117
 None
 1.34A 2x7hA-1si8A:
0.0
2x7hB-1si8A:
0.0		 2x7hA-1si8A:
23.28
2x7hB-1si8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 8 PHE A 111
GLY A 126
GLY A  59
MET A 295
 None
HEM  A 501 (-3.8A)
None
None
 0.93A 2y6rB-1si8A:
undetectable		 2y6rB-1si8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 8 GLY A 110
ASN A 128
PHE A 133
ARG A 109
 HEM  A 501 (-3.3A)
None
None
None
 1.33A 3ccfA-1si8A:
undetectable		 3ccfA-1si8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 8 ALA A  96
THR A  94
GLY A 234
PRO A 237
 None
 0.83A 3ny4A-1si8A:
undetectable		 3ny4A-1si8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 PHE A 111
GLY A 126
ALA A  60
GLY A  59
MET A 295
 None
HEM  A 501 (-3.8A)
None
None
None
 0.99A 3v3oA-1si8A:
undetectable		 3v3oA-1si8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 THR A  94
PHE A 111
GLY A 126
MET A 295
GLN A 219
 None
None
HEM  A 501 (-3.8A)
None
None
 1.24A 3v3oA-1si8A:
undetectable		 3v3oA-1si8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 PHE A 111
GLY A 126
ALA A  60
GLY A  59
MET A 295
 None
HEM  A 501 (-3.8A)
None
None
None
 1.05A 3v3oB-1si8A:
undetectable		 3v3oB-1si8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 ILE A 474
VAL A 470
TYR A 466
THR A 176
ILE A 452
 None
 1.26A 3vrjA-1si8A:
undetectable
3vrjC-1si8A:
undetectable		 3vrjA-1si8A:
19.38
3vrjC-1si8A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 5 ASP A 277
GLU A 170
TYR A 412
ASP A 327
 None
 1.34A 3w9tD-1si8A:
undetectable		 3w9tD-1si8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 11 PHE A 111
GLY A 126
ALA A  60
GLY A  59
MET A 295
 None
HEM  A 501 (-3.8A)
None
None
None
 1.20A 4a6nA-1si8A:
undetectable		 4a6nA-1si8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 LYS A  56
THR A  94
ILE A 184
 None
 0.71A 4e0fB-1si8A:
undetectable		 4e0fB-1si8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 6 GLY A 126
ASP A 123
PRO A 315
ARG A 333
 HEM  A 501 (-3.8A)
None
None
HEM  A 501 (-3.5A)
 1.04A 4lajA-1si8A:
undetectable
4lajB-1si8A:
undetectable		 4lajA-1si8A:
21.71
4lajB-1si8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 6 GLY A 195
ASP A 123
PRO A 315
ARG A 333
 None
None
None
HEM  A 501 (-3.5A)
 0.94A 4lajA-1si8A:
undetectable
4lajB-1si8A:
undetectable		 4lajA-1si8A:
21.71
4lajB-1si8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 12 LEU A 297
GLY A 110
ASN A 127
ALA A  90
GLY A 195
 None
HEM  A 501 (-3.3A)
HEM  A 501 (-3.2A)
None
None
 1.16A 4n09A-1si8A:
undetectable		 4n09A-1si8A:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_C_HQEC503_1
(CATALASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 8 ASP A 107
PRO A 108
PHE A 133
LEU A 178
 None
 0.46A 4qopC-1si8A:
57.1		 4qopC-1si8A:
50.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 10 PHE A 188
PHE A 313
LEU A 113
ALA A  90
ALA A  58
 None
HEM  A 501 (-4.5A)
None
None
None
 1.09A 4wnuD-1si8A:
undetectable		 4wnuD-1si8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 SER A 166
GLU A 450
ASP A 163
 None
 0.86A 4xudA-1si8A:
undetectable		 4xudA-1si8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 7 MET A 191
HIS A  54
GLY A 126
ASN A 127
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.8A)
HEM  A 501 (-3.2A)
 1.39A 5a5zC-1si8A:
undetectable		 5a5zC-1si8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 ALA A 422
ASN A 425
LEU A 426
 None
 0.50A 5i1nC-1si8A:
undetectable		 5i1nC-1si8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 ALA A 422
ASN A 425
LEU A 426
 None
 0.39A 5i1pA-1si8A:
undetectable		 5i1pA-1si8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 ALA A 422
ASN A 425
LEU A 426
 None
 0.49A 5i1pD-1si8A:
undetectable		 5i1pD-1si8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1si8 CATALASE
(Enterococcus
faecalis) 		5 / 9 GLY A 467
ALA A 440
VAL A 470
GLU A 433
ILE A 456
 None
 1.32A 5i3cA-1si8A:
undetectable		 5i3cA-1si8A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 8 TYR A 337
ASP A 327
VAL A 125
GLY A 126
 HEM  A 501 (-3.8A)
None
HEM  A 501 (-4.8A)
HEM  A 501 (-3.8A)
 0.96A 5nzyA-1si8A:
undetectable		 5nzyA-1si8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 GLN A 455
TRP A 162
VAL A 446
 None
 1.09A 6auuA-1si8A:
undetectable		 6auuA-1si8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 LEU A 244
THR A 217
ASN A 218
 None
 0.64A 6baaE-1si8A:
undetectable		 6baaE-1si8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 LEU A 244
THR A 217
ASN A 218
 None
 0.65A 6baaF-1si8A:
undetectable		 6baaF-1si8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 LEU A 244
THR A 217
ASN A 218
 None
 0.65A 6baaG-1si8A:
undetectable		 6baaG-1si8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1si8 CATALASE
(Enterococcus
faecalis) 		3 / 3 LEU A 244
THR A 217
ASN A 218
 None
 0.65A 6baaH-1si8A:
undetectable		 6baaH-1si8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 1si8 CATALASE
(Enterococcus
faecalis) 		4 / 8 ARG A 149
GLY A 100
LEU A  99
ALA A  55
 None
 0.80A 6mdqA-1si8A:
undetectable		 6mdqA-1si8A:
11.79