SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		3 / 3 TRP A  98
VAL A 190
TRP A 227
 None
 1.29A 1gmkC-1sieA:
undetectable
1gmkD-1sieA:
undetectable		 1gmkC-1sieA:
4.22
1gmkD-1sieA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		4 / 6 PHE A 165
PHE A 240
THR A 127
VAL A 125
 None
 1.06A 3lb3A-1sieA:
undetectable		 3lb3A-1sieA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		4 / 6 PHE A 165
PHE A 240
THR A 127
VAL A 125
 None
 1.05A 3lb3B-1sieA:
undetectable		 3lb3B-1sieA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		3 / 3 THR A 147
PRO A 144
THR A 150
 None
 0.87A 4hivD-1sieA:
undetectable		 4hivD-1sieA:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		3 / 3 HIS A 163
GLY A 287
ILE A 285
 None
 0.51A 4k50A-1sieA:
undetectable		 4k50A-1sieA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		3 / 3 HIS A 163
GLY A 287
ILE A 285
 None
 0.50A 4k50I-1sieA:
undetectable		 4k50I-1sieA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		3 / 3 PRO A 144
VAL A 290
HIS A 298
 None
None
SIA  A 384 (-3.6A)
 0.83A 4pevC-1sieA:
undetectable		 4pevC-1sieA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		3 / 3 TYR A 305
LYS A 307
LYS A 126
 None
 1.22A 5dbyA-1sieA:
undetectable		 5dbyA-1sieA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		4 / 5 PRO A  90
GLY A  91
THR A  94
ASN A  92
 None
GAL  A 385 ( 4.6A)
None
None
 1.21A 5x23A-1sieA:
undetectable		 5x23A-1sieA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1sie POLYOMAVIRUS COAT
PROTEIN VP1
(Mus
musculus
polyomavirus
1) 		4 / 6 PRO A  90
GLY A  91
THR A  94
ASN A  92
 None
GAL  A 385 ( 4.6A)
None
None
 1.05A 5xxiA-1sieA:
0.0		 5xxiA-1sieA:
22.27