SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 6 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.53A 2fcnA-1sifA:
15.1
2fcnB-1sifA:
14.8		 2fcnA-1sifA:
90.79
2fcnB-1sifA:
90.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 7 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.65A 4w5oA-1sifA:
undetectable		 4w5oA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.62A 4w5qA-1sifA:
undetectable		 4w5qA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.77A 4w5tA-1sifA:
undetectable		 4w5tA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  43
LEU A  67
GLU A  24
LEU A  26
LEU A  56
 None
 1.05A 4wg0B-1sifA:
undetectable
4wg0C-1sifA:
undetectable
4wg0D-1sifA:
undetectable		 4wg0B-1sifA:
12.24
4wg0C-1sifA:
12.24
4wg0D-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  43
LEU A  67
LYS A  27
LEU A  26
LEU A  56
 None
 1.12A 4wg0B-1sifA:
undetectable
4wg0C-1sifA:
undetectable
4wg0D-1sifA:
undetectable		 4wg0B-1sifA:
12.24
4wg0C-1sifA:
12.24
4wg0D-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  43
LEU A  67
GLU A  24
LEU A  26
LEU A  56
 None
 1.05A 4wg0D-1sifA:
undetectable
4wg0E-1sifA:
undetectable
4wg0F-1sifA:
undetectable		 4wg0D-1sifA:
12.24
4wg0E-1sifA:
12.24
4wg0F-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  43
LEU A  67
LYS A  27
LEU A  26
LEU A  56
 None
 1.13A 4wg0D-1sifA:
undetectable
4wg0E-1sifA:
undetectable
4wg0F-1sifA:
undetectable		 4wg0D-1sifA:
12.24
4wg0E-1sifA:
12.24
4wg0F-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  56
GLU A  24
LEU A  26
LEU A  43
LEU A  67
 None
 0.97A 4wg0C-1sifA:
undetectable
4wg0D-1sifA:
undetectable
4wg0E-1sifA:
undetectable		 4wg0C-1sifA:
12.24
4wg0D-1sifA:
12.24
4wg0E-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  43
LEU A  67
GLU A  24
LEU A  26
LEU A  56
 None
 0.97A 4wg0F-1sifA:
undetectable
4wg0G-1sifA:
undetectable
4wg0H-1sifA:
undetectable		 4wg0F-1sifA:
12.24
4wg0G-1sifA:
12.24
4wg0H-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  56
GLU A  24
LEU A  26
LEU A  43
LEU A  67
 None
 0.95A 4wg0E-1sifA:
undetectable
4wg0F-1sifA:
undetectable
4wg0G-1sifA:
undetectable		 4wg0E-1sifA:
12.24
4wg0F-1sifA:
12.24
4wg0G-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  56
GLU A  24
LEU A  26
LEU A  43
LEU A  67
 None
 0.94A 4wg0G-1sifA:
undetectable
4wg0H-1sifA:
undetectable
4wg0I-1sifA:
undetectable		 4wg0G-1sifA:
12.24
4wg0H-1sifA:
12.24
4wg0I-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  43
LEU A  67
GLU A  24
LEU A  26
LEU A  56
 None
 1.06A 4wg0J-1sifA:
undetectable
4wg0K-1sifA:
undetectable
4wg0L-1sifA:
undetectable		 4wg0J-1sifA:
12.24
4wg0K-1sifA:
12.24
4wg0L-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  56
GLU A  24
LEU A  26
LEU A  43
LEU A  67
 None
 1.07A 4wg0I-1sifA:
undetectable
4wg0J-1sifA:
undetectable
4wg0K-1sifA:
undetectable		 4wg0I-1sifA:
12.24
4wg0J-1sifA:
12.24
4wg0K-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		5 / 11 LEU A  56
LYS A  27
LEU A  26
LEU A  43
LEU A  67
 None
 1.10A 4wg0I-1sifA:
undetectable
4wg0J-1sifA:
undetectable
4wg0K-1sifA:
undetectable		 4wg0I-1sifA:
12.24
4wg0J-1sifA:
12.24
4wg0K-1sifA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 7 LEU A  43
LEU A  67
GLU A  24
LEU A  26
 None
 0.82A 4wg0L-1sifA:
undetectable
4wg0M-1sifA:
undetectable		 4wg0L-1sifA:
12.24
4wg0M-1sifA:
12.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 4 LEU A   8
ILE A  44
HIS A  68
VAL A  70
 None
 0.69A 4xyzA-1sifA:
15.5		 4xyzA-1sifA:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.65A 4z4cA-1sifA:
undetectable		 4z4cA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.64A 4z4dA-1sifA:
undetectable		 4z4dA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 7 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.63A 4z4eA-1sifA:
undetectable		 4z4eA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 7 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.64A 4z4gA-1sifA:
0.0		 4z4gA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1sif UBIQUITIN
(Homo
sapiens) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.73A 6cbdA-1sifA:
undetectable		 6cbdA-1sifA:
8.43