SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		4 / 7 PHE A 419
PHE A 427
ALA A 120
ILE A 123
 None
 0.94A 1fxhA-1sigA:
undetectable
1fxhB-1sigA:
undetectable		 1fxhA-1sigA:
21.31
1fxhB-1sigA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		4 / 8 ASP A 173
CYH A 132
ASP A 125
GLU A 124
 None
 1.03A 4feuF-1sigA:
1.0		 4feuF-1sigA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		4 / 8 ASP A 173
CYH A 132
ASP A 125
GLU A 124
 None
 1.09A 4fewF-1sigA:
1.0		 4fewF-1sigA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		4 / 8 ASP A 173
CYH A 132
ASP A 125
GLU A 124
 None
 1.05A 4gkhB-1sigA:
undetectable		 4gkhB-1sigA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		4 / 8 ASP A 173
CYH A 132
ASP A 125
GLU A 124
 None
 1.03A 4gkhD-1sigA:
undetectable		 4gkhD-1sigA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		4 / 8 ASP A 173
CYH A 132
ASP A 125
GLU A 124
 None
 1.07A 4gkiA-1sigA:
1.0		 4gkiA-1sigA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		5 / 12 GLY A 408
ALA A 438
ILE A 405
VAL A 387
ILE A 388
 None
 1.11A 4uw0A-1sigA:
undetectable		 4uw0A-1sigA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		4 / 6 ASN A 362
ASP A 278
THR A 351
VAL A 358
 None
 1.06A 4yoaA-1sigA:
undetectable		 4yoaA-1sigA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		5 / 10 PHE A 165
ARG A 157
LEU A 161
ILE A 162
SER A 159
 None
 1.47A 4z69I-1sigA:
2.1		 4z69I-1sigA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		3 / 3 LEU A 190
GLN A 187
LYS A 376
 None
 0.95A 6exiB-1sigA:
undetectable		 6exiB-1sigA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR
(Escherichia
coli) 		3 / 3 LEU A 190
GLN A 187
LYS A 376
 None
 0.97A 6exiA-1sigA:
undetectable		 6exiA-1sigA:
13.73