SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1siq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 ARG A  88
SER A 261
GLY A 259
ARG A  84
ASN A 330
 None
 1.49A 1ho5B-1siqA:
undetectable		 1ho5B-1siqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 GLY A 310
ASP A 314
TYR A 251
TRP A 255
 None
 1.14A 1kf6M-1siqA:
0.0
1kf6N-1siqA:
0.0		 1kf6M-1siqA:
19.49
1kf6N-1siqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 8 LEU A 130
ALA A  96
GLY A 127
LEU A  62
GLY A  63
 None
 1.31A 2yfxA-1siqA:
undetectable		 2yfxA-1siqA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A  98
MET A  56
PHE A  48
ILE A  52
PHE A  27
 None
 1.45A 3aocC-1siqA:
undetectable		 3aocC-1siqA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 GLY A 310
ASP A 314
SER A  75
 None
 0.65A 3brfA-1siqA:
undetectable		 3brfA-1siqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 LEU A  35
ALA A  42
LEU A 212
VAL A  89
ILE A  39
 None
None
FAD  A 399 (-4.2A)
None
None
 0.93A 3em3A-1siqA:
undetectable		 3em3A-1siqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 121
GLN A 100
LEU A 193
LEU A 177
GLY A 131
 None
 1.19A 3g1uB-1siqA:
undetectable		 3g1uB-1siqA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 PHE A 263
CYH A 264
HIS A 359
 None
 1.34A 3u9fL-1siqA:
undetectable		 3u9fL-1siqA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ARG A  34
GLU A  58
ARG A  38
 None
 0.94A 4mwvA-1siqA:
undetectable		 4mwvA-1siqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 PRO A 234
LEU A 233
HIS A 106
 None
 0.70A 4pevA-1siqA:
undetectable		 4pevA-1siqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ARG A  28
HIS A 266
ARG A  88
 None
 1.06A 5iaoC-1siqA:
undetectable		 5iaoC-1siqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ARG A  28
HIS A 266
ARG A  88
 None
 1.07A 5iaoF-1siqA:
undetectable		 5iaoF-1siqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 THR A  65
SER A  76
ASP A 316
 None
 0.70A 5kvaA-1siqA:
undetectable		 5kvaA-1siqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 THR A  65
SER A  76
ASP A 316
 None
 0.69A 5kvaB-1siqA:
undetectable		 5kvaB-1siqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 PHE A 133
LEU A 246
GLY A 240
GLY A 112
 None
 0.78A 6eu9D-1siqA:
undetectable		 6eu9D-1siqA:
12.04