SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sj7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1sj7 TALIN 1
(Mus
musculus) 		5 / 12 LEU A 622
ALA A 511
ALA A 509
LEU A 615
ARG A 624
 None
 1.22A 1kt5A-1sj7A:
undetectable		 1kt5A-1sj7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sj7 TALIN 1
(Mus
musculus) 		4 / 7 VAL A 573
VAL A 577
SER A 581
VAL A 619
 None
 0.74A 3hs6B-1sj7A:
undetectable		 3hs6B-1sj7A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1sj7 TALIN 1
(Mus
musculus) 		4 / 7 LEU A 495
SER A 501
ASN A 500
THR A 578
 None
 0.87A 3lm8A-1sj7A:
undetectable
3lm8C-1sj7A:
undetectable		 3lm8A-1sj7A:
17.67
3lm8C-1sj7A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1sj7 TALIN 1
(Mus
musculus) 		5 / 9 ILE A 543
LEU A 584
THR A 554
GLU A 650
GLY A 617
 None
 1.45A 3nxuB-1sj7A:
undetectable		 3nxuB-1sj7A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1sj7 TALIN 1
(Mus
musculus) 		5 / 11 ALA A 616
LEU A 513
LEU A 594
GLY A 590
LEU A 584
 None
 1.10A 3zosA-1sj7A:
undetectable
3zosB-1sj7A:
undetectable		 3zosA-1sj7A:
18.01
3zosB-1sj7A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 1sj7 TALIN 1
(Mus
musculus) 		4 / 8 LEU A 651
GLY A 649
GLU A 650
ALA A 641
 None
 0.82A 4rjdA-1sj7A:
undetectable
4rjdB-1sj7A:
undetectable		 4rjdA-1sj7A:
19.42
4rjdB-1sj7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 1sj7 TALIN 1
(Mus
musculus) 		4 / 4 LEU A 615
LEU A 652
GLY A 649
GLU A 650
 None
 0.97A 5hhjA-1sj7A:
undetectable		 5hhjA-1sj7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sj7 TALIN 1
(Mus
musculus) 		5 / 5 LEU A 593
LYS A 592
ALA A 595
LEU A 598
LEU A 609
 None
 1.40A 5vkqA-1sj7A:
3.5
5vkqD-1sj7A:
3.5		 5vkqA-1sj7A:
7.73
5vkqD-1sj7A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sj7 TALIN 1
(Mus
musculus) 		5 / 5 LEU A 609
LEU A 593
LYS A 592
ALA A 595
LEU A 598
 None
 1.39A 5vkqA-1sj7A:
3.5
5vkqB-1sj7A:
3.5		 5vkqA-1sj7A:
7.73
5vkqB-1sj7A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sj7 TALIN 1
(Mus
musculus) 		5 / 5 LEU A 609
LEU A 593
LYS A 592
ALA A 595
LEU A 598
 None
 1.38A 5vkqB-1sj7A:
3.5
5vkqC-1sj7A:
3.5		 5vkqB-1sj7A:
7.73
5vkqC-1sj7A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sj7 TALIN 1
(Mus
musculus) 		5 / 5 LEU A 609
LEU A 593
LYS A 592
ALA A 595
LEU A 598
 None
 1.39A 5vkqC-1sj7A:
3.5
5vkqD-1sj7A:
3.5		 5vkqC-1sj7A:
7.73
5vkqD-1sj7A:
7.73