SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 6 LEU A 598
GLU A 601
ALA A 596
LEU A 608
 None
 1.19A 1etb1-1sj8A:
undetectable		 1etb1-1sj8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1sj8 TALIN 1
(Mus
musculus) 		5 / 11 LEU A 495
ALA A 505
VAL A 577
LEU A 623
GLN A 627
 None
 1.35A 1hbpA-1sj8A:
undetectable		 1hbpA-1sj8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 8 ALA A 676
ALA A 672
GLY A 740
ALA A 777
 None
 0.92A 2vh3B-1sj8A:
2.3		 2vh3B-1sj8A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 7 VAL A 573
VAL A 577
SER A 581
VAL A 619
 None
 0.90A 3hs6B-1sj8A:
undetectable		 3hs6B-1sj8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1sj8 TALIN 1
(Mus
musculus) 		3 / 3 ARG A 741
ASP A 564
GLN A 701
 None
 0.90A 3lcvB-1sj8A:
undetectable		 3lcvB-1sj8A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sj8 TALIN 1
(Mus
musculus) 		6 / 12 SER A 714
LEU A 638
ALA A 679
VAL A 743
GLY A 740
ALA A 739
 None
 1.24A 3ln1D-1sj8A:
undetectable		 3ln1D-1sj8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1sj8 TALIN 1
(Mus
musculus) 		5 / 11 THR A 561
GLY A 553
THR A 554
ALA A 555
CYH A 719
 None
 1.20A 3mg0H-1sj8A:
undetectable
3mg0I-1sj8A:
undetectable		 3mg0H-1sj8A:
22.29
3mg0I-1sj8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1sj8 TALIN 1
(Mus
musculus) 		5 / 9 ILE A 543
LEU A 584
THR A 554
GLU A 650
GLY A 617
 None
 1.31A 3nxuB-1sj8A:
undetectable		 3nxuB-1sj8A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 7 ILE A 580
LEU A 623
ALA A 641
ALA A 640
 None
 0.84A 3r9tB-1sj8A:
undetectable		 3r9tB-1sj8A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 7 ALA A 770
ARG A 741
GLY A 740
GLU A 738
 None
 0.84A 5bs8A-1sj8A:
undetectable
5bs8C-1sj8A:
undetectable
5bs8D-1sj8A:
undetectable		 5bs8A-1sj8A:
20.12
5bs8C-1sj8A:
20.12
5bs8D-1sj8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 6 ALA A 770
ARG A 741
GLY A 740
GLU A 738
 None
 0.89A 5btgA-1sj8A:
1.8
5btgB-1sj8A:
undetectable
5btgC-1sj8A:
undetectable		 5btgA-1sj8A:
20.12
5btgB-1sj8A:
22.01
5btgC-1sj8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 7 ALA A 770
ARG A 741
GLY A 740
GLU A 738
 None
 0.90A 5btgA-1sj8A:
1.8
5btgC-1sj8A:
undetectable
5btgD-1sj8A:
undetectable		 5btgA-1sj8A:
20.12
5btgC-1sj8A:
20.12
5btgD-1sj8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sj8 TALIN 1
(Mus
musculus) 		5 / 11 THR A 561
GLY A 553
THR A 554
ALA A 555
CYH A 719
 None
 1.20A 5bxnV-1sj8A:
undetectable
5bxnW-1sj8A:
undetectable		 5bxnV-1sj8A:
22.36
5bxnW-1sj8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 6 LEU A 594
LEU A 513
LEU A 609
LEU A 651
 None
 0.94A 5gs4A-1sj8A:
1.4		 5gs4A-1sj8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 4 LEU A 615
LEU A 652
GLY A 649
GLU A 650
 None
 1.03A 5hhjA-1sj8A:
0.2		 5hhjA-1sj8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1sj8 TALIN 1
(Mus
musculus) 		4 / 5 LYS A 540
ILE A 543
HIS A 544
VAL A 547
 None
 0.81A 5jmnA-1sj8A:
undetectable		 5jmnA-1sj8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1sj8 TALIN 1
(Mus
musculus) 		3 / 3 VAL A 591
HIS A 544
VAL A 547
 None
 0.55A 5jmnC-1sj8A:
undetectable		 5jmnC-1sj8A:
16.00