SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sji'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		3 / 3 SER A 154
GLU A 155
GLU A 156
 None
 0.60A 1eqbD-1sjiA:
undetectable		 1eqbD-1sjiA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		3 / 3 SER A 154
GLU A 155
GLU A 156
 None
 0.60A 1eqbB-1sjiA:
undetectable		 1eqbB-1sjiA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		5 / 7 GLY A 108
VAL A 114
ASP A 291
LEU A 233
ARG A 232
 None
 1.21A 2uyqA-1sjiA:
undetectable		 2uyqA-1sjiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		5 / 12 GLY A 150
LEU A 190
PHE A 139
PRO A 205
ILE A 149
 None
 0.99A 2y7kD-1sjiA:
undetectable		 2y7kD-1sjiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		5 / 12 TYR A 160
PHE A 176
GLY A 150
VAL A 222
PHE A 170
 None
 1.19A 2zzmA-1sjiA:
undetectable		 2zzmA-1sjiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		4 / 7 VAL A 116
VAL A  97
ILE A 123
ARG A  14
 None
 1.28A 3ms9B-1sjiA:
undetectable		 3ms9B-1sjiA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		3 / 3 SER A  42
SER A  43
HIS A  38
 None
 0.80A 3mzeA-1sjiA:
undetectable		 3mzeA-1sjiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		4 / 8 ASP A 121
ASP A 144
ARG A 232
GLU A 128
 None
 1.05A 4gkhF-1sjiA:
0.0		 4gkhF-1sjiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		4 / 8 PRO A 228
ASN A 279
ILE A 284
MET A 202
 None
 1.06A 4iilA-1sjiA:
2.6		 4iilA-1sjiA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		3 / 3 TRP A 286
ILE A 287
ASP A 288
 None
 0.82A 6i0y7-1sjiA:
undetectable		 6i0y7-1sjiA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM
(Canis
lupus) 		5 / 10 ASP A  90
TYR A  96
ASP A  76
GLY A  93
GLU A  39
 None
 1.29A 6mb9D-1sjiA:
0.0		 6mb9D-1sjiA:
12.39