SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 391
GLU A 394
ALA A 396
SER A 149
 None
 1.13A 1errA-1sjpA:
0.0
1errB-1sjpA:
0.0		 1errA-1sjpA:
18.91
1errB-1sjpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 500
GLU A 123
ALA A 504
LEU A  93
 None
 1.14A 1eta1-1sjpA:
undetectable		 1eta1-1sjpA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		3 / 4 LYS A 401
ALA A 400
MET A 163
 None
 1.01A 1hk3A-1sjpA:
undetectable		 1hk3A-1sjpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 217
GLY A 189
ALA A 370
MET A 190
GLY A 334
 None
 1.17A 1kiaB-1sjpA:
undetectable		 1kiaB-1sjpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 7 LYS A 124
GLU A 127
ALA A 121
LEU A 428
 None
 0.98A 1sn0B-1sjpA:
undetectable
1sn0D-1sjpA:
undetectable		 1sn0B-1sjpA:
14.03
1sn0D-1sjpA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 292
GLU A 331
LEU A 369
VAL A 166
 None
 1.15A 1sn5A-1sjpA:
undetectable		 1sn5A-1sjpA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 262
PHE A 201
ALA A 210
VAL A 224
LEU A 234
 None
 1.06A 1xdkA-1sjpA:
undetectable		 1xdkA-1sjpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 246
ASN A 262
PHE A 201
VAL A 224
LEU A 234
 None
 0.87A 1xdkA-1sjpA:
undetectable		 1xdkA-1sjpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 158
VAL A 166
GLY A 167
ALA A 374
LEU A 186
 None
 1.22A 2bxgA-1sjpA:
2.6		 2bxgA-1sjpA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 288
LEU A 369
LYS A 368
ARG A 342
 None
 1.35A 2gj5A-1sjpA:
0.0		 2gj5A-1sjpA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 492
ASN A 399
ARG A 398
 None
 1.08A 2qeuB-1sjpA:
2.6		 2qeuB-1sjpA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 429
VAL A 441
ALA A 442
LEU A 114
ARG A 116
 None
 1.37A 3a3yA-1sjpA:
undetectable		 3a3yA-1sjpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 234
ALA A 255
THR A 327
VAL A 320
ILE A 217
 None
 1.03A 3c6gA-1sjpA:
undetectable		 3c6gA-1sjpA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 246
ASN A 262
PHE A 201
VAL A 224
LEU A 234
 None
 1.07A 3dzyA-1sjpA:
undetectable		 3dzyA-1sjpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 335
GLY A 189
ALA A 290
GLY A 295
ILE A 329
 None
 0.93A 3ku1C-1sjpA:
undetectable		 3ku1C-1sjpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		3 / 3 THR A 187
VAL A 373
GLU A 185
 None
 0.72A 3v4tA-1sjpA:
undetectable
3v4tD-1sjpA:
undetectable		 3v4tA-1sjpA:
24.24
3v4tD-1sjpA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 130
LEU A 500
THR A 415
VAL A 409
 None
 1.04A 4udaA-1sjpA:
undetectable		 4udaA-1sjpA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 158
LEU A 184
ALA A 146
MET A 163
ALA A 162
 None
 1.47A 5g44A-1sjpA:
0.1		 5g44A-1sjpA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 473
LEU A 417
THR A 478
ALA A 410
LEU A 484
ALA A 487
 None
 1.43A 5kpcA-1sjpA:
undetectable		 5kpcA-1sjpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		5 / 9 THR A 293
GLY A 294
ALA A 333
GLY A 295
LEU A 219
 None
 0.94A 5vw4A-1sjpA:
undetectable		 5vw4A-1sjpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 8 THR A 293
GLY A 294
ALA A 333
GLY A 295
 None
 0.71A 5vw9A-1sjpA:
undetectable		 5vw9A-1sjpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 476
VAL A 465
TYR A 481
 None
 0.69A 5zmqH-1sjpA:
undetectable		 5zmqH-1sjpA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 359
ILE A 350
SER A 353
 None
 0.77A 5zw2A-1sjpA:
undetectable		 5zw2A-1sjpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 234
LEU A 231
LEU A 256
GLY A 253
 None
 0.80A 6ce2A-1sjpA:
2.1		 6ce2A-1sjpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 369
THR A 293
PRO A 276
ARG A 282
 None
 1.26A 6ew0B-1sjpA:
0.3		 6ew0B-1sjpA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 369
THR A 293
PRO A 276
ARG A 282
 None
 1.26A 6ew0D-1sjpA:
0.2		 6ew0D-1sjpA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 369
THR A 293
PRO A 276
ARG A 282
 None
 1.26A 6ew0H-1sjpA:
0.0		 6ew0H-1sjpA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1sjp 60 KDA CHAPERONIN 2
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 369
THR A 293
PRO A 276
ARG A 282
 None
 1.26A 6ew0I-1sjpA:
0.0		 6ew0I-1sjpA:
11.04