SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sjx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 1sjx IMMUNOGLOBULIN VH
DOMAIN
(Lama
glama) 		6 / 12 VAL A 802
LEU A 804
MET A 834
VAL A 878
ALA A 897
TYR A 908
 None
None
MPD  A8001 ( 3.5A)
None
None
None
 0.87A 3qxtB-1sjxA:
21.0		 3qxtB-1sjxA:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 1sjx IMMUNOGLOBULIN VH
DOMAIN
(Lama
glama) 		5 / 11 GLN A 911
MET A 834
GLY A 910
GLY A 826
ASN A 876
 None
MPD  A8001 ( 3.5A)
None
None
None
 1.39A 3v3nA-1sjxA:
undetectable		 3v3nA-1sjxA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1sjx IMMUNOGLOBULIN VH
DOMAIN
(Lama
glama) 		5 / 11 GLN A 911
MET A 834
GLY A 910
GLY A 826
ASN A 876
 None
MPD  A8001 ( 3.5A)
None
None
None
 1.39A 3v3nD-1sjxA:
undetectable		 3v3nD-1sjxA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 1sjx IMMUNOGLOBULIN VH
DOMAIN
(Lama
glama) 		5 / 11 GLN A 911
MET A 834
GLY A 910
GLY A 826
ASN A 876
 None
MPD  A8001 ( 3.5A)
None
None
None
 1.42A 4a99D-1sjxA:
undetectable		 4a99D-1sjxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 1sjx IMMUNOGLOBULIN VH
DOMAIN
(Lama
glama) 		3 / 3 TYR A 859
GLY A 865
THR A 868
 None
 0.19A 6cjkB-1sjxA:
19.9		 6cjkB-1sjxA:
28.82