SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1skx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		4 / 4 ILE A 254
MET A 246
VAL A 291
GLY A 253
 None
 1.21A 1e06B-1skxA:
undetectable		 1e06B-1skxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		3 / 3 PHE A 172
LEU A 215
LEU A 213
 None
 0.67A 1mx1E-1skxA:
1.1		 1mx1E-1skxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		4 / 4 LEU A 154
LEU A 348
SER A 347
LEU A 286
 None
 0.91A 1ya3A-1skxA:
19.6		 1ya3A-1skxA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 12 PHE A 369
LEU A 342
ALA A 157
SER A 262
TYR A 263
 None
 1.38A 3apvA-1skxA:
undetectable		 3apvA-1skxA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 12 PHE A 369
LEU A 342
ALA A 157
SER A 262
TYR A 263
 None
 1.38A 3apwB-1skxA:
undetectable		 3apwB-1skxA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		4 / 8 PHE A 169
LEU A 215
TYR A 306
LEU A 174
 None
 1.02A 3i45A-1skxA:
undetectable		 3i45A-1skxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 12 SER A 247
THR A 248
ILE A 414
LEU A 412
LEU A 428
 RFP  A   1 (-3.1A)
None
RFP  A   1 ( 4.2A)
None
None
 1.19A 3lcvB-1skxA:
undetectable		 3lcvB-1skxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 11 ASP A 266
LEU A 365
PHE A 369
ILE A 261
SER A 262
 None
 1.45A 3o94A-1skxA:
undetectable		 3o94A-1skxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 11 ASP A 266
LEU A 365
PHE A 369
ILE A 261
SER A 262
 None
 1.48A 3o94B-1skxA:
undetectable		 3o94B-1skxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 11 ASP A 266
LEU A 365
PHE A 369
ILE A 261
SER A 262
 None
 1.48A 3o94C-1skxA:
undetectable		 3o94C-1skxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 11 ASP A 266
LEU A 365
PHE A 369
ILE A 261
SER A 262
 None
 1.47A 3o94D-1skxA:
undetectable		 3o94D-1skxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		3 / 3 LEU A 239
HIS A 242
MET A 243
 None
None
RFP  A   1 (-3.5A)
 0.61A 3thrD-1skxA:
undetectable		 3thrD-1skxA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		3 / 3 GLN A 383
HIS A 386
ARG A 381
 None
 1.27A 4qyqA-1skxA:
0.0		 4qyqA-1skxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		3 / 3 GLN A 383
HIS A 386
ARG A 381
 None
 1.18A 4qyqB-1skxA:
0.0		 4qyqB-1skxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		4 / 7 LEU A 373
MET A 343
ALA A 345
MET A 155
 None
 1.02A 4rjdB-1skxA:
undetectable		 4rjdB-1skxA:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		7 / 12 LEU A 240
SER A 247
PHE A 251
ARG A 410
LEU A 411
ILE A 414
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-3.1A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
RFP  A   1 ( 4.2A)
None
 0.72A 4x1fA-1skxA:
37.9		 4x1fA-1skxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		6 / 12 MET A 243
PHE A 251
ARG A 410
LEU A 411
ILE A 414
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
RFP  A   1 ( 4.2A)
None
 0.86A 4x1fA-1skxA:
37.9		 4x1fA-1skxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		7 / 12 LEU A 240
SER A 247
PHE A 251
ARG A 410
LEU A 411
ILE A 414
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-3.1A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
RFP  A   1 ( 4.2A)
None
 0.73A 4x1gA-1skxA:
37.7		 4x1gA-1skxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 12 MET A 243
PHE A 251
ARG A 410
LEU A 411
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
None
 1.01A 4x1gA-1skxA:
37.7		 4x1gA-1skxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 11 VAL A 356
GLY A 355
ASP A 352
SER A 274
LEU A 275
 None
 0.96A 5x6yA-1skxA:
undetectable		 5x6yA-1skxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		3 / 3 ARG A 410
LYS A 210
ARG A 413
 RFP  A   1 ( 4.2A)
RFP  A   1 (-3.5A)
None
 1.29A 6az3C-1skxA:
0.0
6az3L-1skxA:
0.0
6az3M-1skxA:
undetectable		 6az3C-1skxA:
10.53
6az3L-1skxA:
13.85
6az3M-1skxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 10 LEU A 348
ALA A 345
LEU A 154
MET A 155
LEU A 373
 None
 1.34A 6cbzB-1skxA:
21.1		 6cbzB-1skxA:
14.18