SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1slm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 10 LEU A  54
VAL A  80
TYR A  25
TYR A  24
LEU A 222
 None
 1.43A 1fkoA-1slmA:
undetectable		 1fkoA-1slmA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.22A 1os2A-1slmA:
28.6		 1os2A-1slmA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.23A 1os2D-1slmA:
28.6		 1os2D-1slmA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.32A 1uttA-1slmA:
28.7		 1uttA-1slmA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.24A 1utzA-1slmA:
29.1		 1utzA-1slmA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.27A 1utzB-1slmA:
29.2		 1utzB-1slmA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 6 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.25A 1y93A-1slmA:
28.1		 1y93A-1slmA:
41.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 10 HIS A 201
HIS A 211
HIS A 205
ASP A 181
PHE A 180
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 3.1A)
ZN  A 257 ( 3.2A)
CA  A 259 ( 3.3A)
None
 1.41A 2dttA-1slmA:
undetectable
2dttC-1slmA:
undetectable		 2dttA-1slmA:
17.25
2dttC-1slmA:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.24A 2hu6A-1slmA:
28.6		 2hu6A-1slmA:
41.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 9 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 2jihA-1slmA:
9.7		 2jihA-1slmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 8 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.38A 2jihB-1slmA:
10.1		 2jihB-1slmA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 6 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.32A 2ow9A-1slmA:
28.3		 2ow9A-1slmA:
43.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 2ow9B-1slmA:
28.4		 2ow9B-1slmA:
43.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 2ozrC-1slmA:
28.4		 2ozrC-1slmA:
43.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 2ozrD-1slmA:
28.5		 2ozrD-1slmA:
43.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.38A 2ozrE-1slmA:
28.3		 2ozrE-1slmA:
43.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		3 / 3 HIS A 201
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.31A 2ozrF-1slmA:
28.1		 2ozrF-1slmA:
43.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		3 / 3 HIS A 166
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
 0.39A 3ba0A-1slmA:
26.6		 3ba0A-1slmA:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 12 LEU A 245
GLY A  88
GLY A 208
LEU A 209
PHE A 210
 None
 0.92A 3e23A-1slmA:
undetectable		 3e23A-1slmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 9 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 3hy7A-1slmA:
10.3		 3hy7A-1slmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 9 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.35A 3hy7B-1slmA:
10.2		 3hy7B-1slmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 8 LEU A 222
TYR A 220
PHE A  53
LEU A  54
 None
 1.01A 3i45A-1slmA:
2.4		 3i45A-1slmA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.23A 3kecA-1slmA:
28.4		 3kecA-1slmA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		3 / 3 HIS A 201
GLU A 202
HIS A 205
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
 0.11A 3kecB-1slmA:
28.4		 3kecB-1slmA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.34A 3likA-1slmA:
28.4		 3likA-1slmA:
41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.25A 3lilA-1slmA:
28.7		 3lilA-1slmA:
41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.27A 3ljgA-1slmA:
28.7		 3ljgA-1slmA:
41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.31A 3lkaA-1slmA:
28.5		 3lkaA-1slmA:
46.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 6 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.32A 4a7bA-1slmA:
28.0		 4a7bA-1slmA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
 0.15A 4a7bB-1slmA:
28.6		 4a7bB-1slmA:
43.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 5 GLN A 243
THR A 128
LEU A 218
LEU A 234
 None
 0.99A 4lvcB-1slmA:
undetectable		 4lvcB-1slmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 8 TYR A  99
ILE A 101
ILE A 144
ALA A 199
 None
 0.88A 4ou1A-1slmA:
undetectable		 4ou1A-1slmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1slm STROMELYSIN-1
(Homo
sapiens) 		5 / 8 ALA A 120
LEU A 207
LEU A 218
MET A 219
LEU A 234
 None
 1.21A 5jqbA-1slmA:
1.0
5jqbB-1slmA:
undetectable		 5jqbA-1slmA:
21.26
5jqbB-1slmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 GLN A 243
THR A 128
LEU A 218
LEU A 234
 None
 0.99A 5m5kB-1slmA:
2.2		 5m5kB-1slmA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.24A 5n5jA-1slmA:
28.8		 5n5jA-1slmA:
46.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.19A 5n5kA-1slmA:
28.6		 5n5kA-1slmA:
40.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 7 THR A 227
LEU A 226
THR A 190
TYR A 223
 None
 0.92A 5ov9A-1slmA:
undetectable		 5ov9A-1slmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
CYH A  75
HIS A 211
HIS A 205
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 2.1A)
ZN  A 257 ( 3.1A)
ZN  A 257 ( 3.2A)
 1.40A 5zrdA-1slmA:
undetectable		 5zrdA-1slmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1slm STROMELYSIN-1
(Homo
sapiens) 		3 / 3 LEU A 245
ASN A 175
LEU A  97
 None
 0.68A 6exiA-1slmA:
undetectable		 6exiA-1slmA:
18.54