SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		7 / 12 HIS A 205
TYR A 207
ASP A 328
GLU A 357
ASP A 424
ASP A 468
ARG A 472
 None
 1.04A 1dedA-1smaA:
38.6		 1dedA-1smaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		7 / 12 HIS A 205
TYR A 207
ASP A 328
HIS A 423
ASP A 424
ASP A 468
ARG A 472
 None
 0.82A 1dedA-1smaA:
38.6		 1dedA-1smaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		8 / 12 HIS A 205
TYR A 207
ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
ARG A 472
 None
 0.84A 1dedB-1smaA:
36.6		 1dedB-1smaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 4 THR A  56
LEU A  39
VAL A  75
LEU A  23
 None
 0.94A 1fbmD-1smaA:
undetectable		 1fbmD-1smaA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 ILE A 354
GLY A 356
HIS A 423
MET A 240
TYR A 207
 None
 1.11A 1fm6X-1smaA:
undetectable		 1fm6X-1smaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		8 / 12 TYR A 207
HIS A 247
PHE A 289
ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.88A 1mxdA-1smaA:
28.9		 1mxdA-1smaA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 8 LEU A 188
ILE A 455
ILE A 494
ARG A 497
 None
 0.85A 2bu8A-1smaA:
undetectable		 2bu8A-1smaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 6 LEU A 419
SER A 422
ASP A 424
GLU A 357
 None
 1.04A 2j2pE-1smaA:
undetectable
2j2pF-1smaA:
undetectable		 2j2pE-1smaA:
16.78
2j2pF-1smaA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 8 HIS A 233
LEU A 175
ILE A 178
LEU A 195
LEU A 225
 None
 1.24A 2xfhA-1smaA:
undetectable		 2xfhA-1smaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.85A 3aicA-1smaA:
9.5		 3aicA-1smaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.88A 3aicB-1smaA:
4.7		 3aicB-1smaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		6 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
TYR A 207
 None
 0.92A 3aicC-1smaA:
9.7		 3aicC-1smaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.88A 3aicE-1smaA:
9.7		 3aicE-1smaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.91A 3aicH-1smaA:
9.6		 3aicH-1smaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 8 VAL A 229
LEU A 228
ILE A 322
VAL A 239
LEU A 195
 None
 1.15A 3kp6A-1smaA:
undetectable
3kp6B-1smaA:
undetectable		 3kp6A-1smaA:
13.40
3kp6B-1smaA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 5 GLY A 506
ASP A 526
ARG A 505
GLN A 499
 None
 1.04A 3qx3B-1smaA:
undetectable		 3qx3B-1smaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 8 TYR A  16
HIS A   8
LEU A  39
MET A  57
 None
 1.38A 3uzzB-1smaA:
9.2		 3uzzB-1smaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 VAL A 490
ILE A 190
TYR A 353
SER A 452
LEU A 447
 None
 1.23A 4a84A-1smaA:
undetectable		 4a84A-1smaA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 7 ARG A 504
THR A 450
GLY A 451
VAL A 132
 None
 1.00A 4qwpB-1smaA:
undetectable		 4qwpB-1smaA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 5 ILE A 198
HIS A 247
TYR A 308
VAL A 312
 None
 0.89A 4s0vA-1smaA:
undetectable		 4s0vA-1smaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 7 GLU A 223
CYH A 232
LEU A 185
ILE A 179
 None
 0.98A 4xumA-1smaA:
undetectable		 4xumA-1smaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		3 / 3 LEU A 298
VAL A 329
ASP A 328
 None
 0.47A 4y8wC-1smaA:
undetectable		 4y8wC-1smaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 ARG A 326
ASP A 328
GLU A 357
HIS A 423
ASP A 424
 None
 0.61A 5csyB-1smaA:
19.5		 5csyB-1smaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 12 PRO A 254
PHE A 252
THR A 288
GLU A 251
TYR A 250
 None
 1.37A 5hfjG-1smaA:
undetectable		 5hfjG-1smaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		3 / 3 LEU A 228
LEU A 195
ARG A 200
 None
 0.65A 5hnzB-1smaA:
undetectable		 5hnzB-1smaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 5 PRO A 453
LEU A 486
TYR A 457
PHE A 145
 None
 1.48A 5igjA-1smaA:
3.2		 5igjA-1smaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 6 PHE A 219
PRO A 217
THR A 224
ILE A 215
 None
 1.40A 5ih0A-1smaA:
undetectable		 5ih0A-1smaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 5 ILE A 178
ILE A 237
HIS A 233
VAL A 239
 None
 0.86A 5jmnA-1smaA:
undetectable		 5jmnA-1smaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		3 / 3 THR A 425
SER A 422
ASP A 328
 None
 0.71A 5kvaA-1smaA:
2.0		 5kvaA-1smaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		3 / 3 THR A 425
SER A 422
ASP A 328
 None
 0.69A 5kvaB-1smaA:
2.0		 5kvaB-1smaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 7 ILE A 193
LEU A 175
PHE A 219
ARG A 144
 None
 0.75A 5vc0A-1smaA:
undetectable		 5vc0A-1smaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		6 / 12 TYR A 207
HIS A 247
MET A 295
ASP A 328
HIS A 423
ASP A 424
 None
 1.28A 6ag0A-1smaA:
24.9		 6ag0A-1smaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		4 / 6 GLN A 127
VAL A 132
ARG A 367
PRO A 409
 None
 1.30A 6brdB-1smaA:
undetectable		 6brdB-1smaA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1sma MALTOGENIC AMYLASE
(Thermus
sp.
IM6501) 		5 / 10 LEU A 225
THR A 224
GLY A 177
ILE A 178
ILE A 198
 None
 1.12A 6ebpC-1smaA:
undetectable		 6ebpC-1smaA:
7.50