SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1smk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ILE A  88
ALA A  95
ILE A 117
LEU A  60
THR A  93
 None
 1.16A 1ddrB-1smkA:
undetectable		 1ddrB-1smkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ILE A  88
ALA A  95
ILE A 117
LEU A  60
THR A  93
 None
 1.17A 1ddsB-1smkA:
undetectable		 1ddsB-1smkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 6 ASN A 137
GLY A  54
ILE A  56
ILE A 140
 None
 0.87A 1n49D-1smkA:
undetectable		 1n49D-1smkA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 5 ALA A  81
ALA A  52
TYR A  76
GLN A 103
 None
 1.06A 1xl6A-1smkA:
0.0
1xl6B-1smkA:
0.0		 1xl6A-1smkA:
22.69
1xl6B-1smkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 5 PRO A 227
VAL A 214
VAL A 201
ILE A 250
 None
 0.97A 1z2bC-1smkA:
2.5		 1z2bC-1smkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 8 PHE A 278
ALA A 281
LEU A 314
ASP A 213
 None
 1.12A 2bxkA-1smkA:
undetectable		 2bxkA-1smkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 5 SER A 310
VAL A 217
SER A 300
VAL A 322
 None
 1.33A 2j9cA-1smkA:
undetectable
2j9cB-1smkA:
undetectable
2j9cC-1smkA:
undetectable		 2j9cA-1smkA:
18.52
2j9cB-1smkA:
18.52
2j9cC-1smkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 7 GLY A 218
GLY A 219
VAL A 302
LEU A 325
 None
 0.82A 2oa1B-1smkA:
undetectable		 2oa1B-1smkA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		3 / 3 LEU A  60
PRO A  59
LEU A  63
 None
 0.59A 2po5B-1smkA:
2.3		 2po5B-1smkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ILE A  88
ALA A  95
ILE A 117
LEU A  60
THR A  93
 None
 1.22A 2zzaA-1smkA:
undetectable		 2zzaA-1smkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 11 ILE A  88
ALA A  95
ILE A 117
LEU A  60
THR A  93
 None
 1.23A 2zzaB-1smkA:
undetectable		 2zzaB-1smkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		3 / 3 LEU A 186
GLU A 173
ILE A 170
 None
 0.60A 3czhA-1smkA:
undetectable		 3czhA-1smkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ALA A 109
ILE A 116
LEU A 186
LEU A 144
GLY A 147
 None
 1.12A 3k2hB-1smkA:
undetectable		 3k2hB-1smkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 7 PRO A 183
ILE A 319
LEU A 314
ASN A 158
 None
 0.97A 3p50A-1smkA:
undetectable		 3p50A-1smkA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 7 PRO A 183
ILE A 319
LEU A 314
ASN A 158
 None
 0.98A 3p50B-1smkA:
undetectable		 3p50B-1smkA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 7 PRO A 183
ILE A 319
LEU A 314
ASN A 158
 None
 0.98A 3p50C-1smkA:
undetectable		 3p50C-1smkA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 7 PRO A 183
ILE A 319
LEU A 314
ASN A 158
 None
 0.97A 3p50D-1smkA:
undetectable		 3p50D-1smkA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 7 PRO A 183
ILE A 319
LEU A 314
ASN A 158
 None
 0.98A 3p50E-1smkA:
undetectable		 3p50E-1smkA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 THR A 143
GLY A  51
ILE A 140
LEU A  75
LEU A  60
 None
 1.16A 3q87B-1smkA:
7.2		 3q87B-1smkA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 7 LEU A 228
GLY A 219
ALA A 309
PHE A 297
 None
 0.98A 3tehB-1smkA:
undetectable		 3tehB-1smkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 4 LEU A 286
GLY A 285
LEU A 314
GLU A 320
 None
 1.03A 3tgvB-1smkA:
undetectable		 3tgvB-1smkA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 10 ALA A 281
ARG A 284
GLY A 285
LEU A 187
ILE A 319
 None
 1.14A 3wdmB-1smkA:
3.7		 3wdmB-1smkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 9 ILE A  88
THR A  85
LEU A  75
VAL A  72
LEU A  73
 None
 1.09A 4g1bC-1smkA:
2.0		 4g1bC-1smkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 11 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.92A 4j6cA-1smkA:
undetectable		 4j6cA-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 10 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.93A 4j6cB-1smkA:
undetectable		 4j6cB-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.93A 4j6dA-1smkA:
undetectable		 4j6dA-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.93A 4j6dB-1smkA:
undetectable		 4j6dB-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.94A 4jbtA-1smkA:
undetectable		 4jbtA-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 11 ALA A  81
ALA A  53
ALA A  52
VAL A 118
LEU A 144
 None
 0.93A 4jbtB-1smkA:
0.0		 4jbtB-1smkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 9 LEU A 305
PRO A 306
ASN A 165
ALA A 221
GLU A 342
 None
 1.46A 4omwD-1smkA:
0.0		 4omwD-1smkA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 11 ILE A  88
ALA A  95
ILE A 117
LEU A  60
THR A  93
 None
 1.22A 4qi9C-1smkA:
undetectable		 4qi9C-1smkA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 11 ILE A  88
ALA A  95
ILE A 117
LEU A  60
THR A  93
 None
 1.19A 4qlfA-1smkA:
undetectable		 4qlfA-1smkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 8 LEU A 205
VAL A 204
ILE A 243
LEU A 229
 None
 0.85A 4qrcA-1smkA:
undetectable		 4qrcA-1smkA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 6 TYR A  76
THR A 143
LEU A 144
GLN A 103
 None
 1.30A 4qztA-1smkA:
undetectable		 4qztA-1smkA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 4 LEU A 144
ILE A 140
PRO A 119
LEU A 159
 None
 1.23A 5eb3A-1smkA:
4.0		 5eb3A-1smkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 ILE A  88
ALA A  95
ILE A 117
LEU A  60
THR A  93
 None
 1.16A 5hi6B-1smkA:
undetectable		 5hi6B-1smkA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		4 / 4 GLY A 315
ARG A 185
ASN A 317
LEU A 286
 None
 1.50A 6b58A-1smkA:
3.6		 6b58A-1smkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL
(Citrullus
lanatus) 		5 / 12 THR A 199
VAL A 204
ASP A 193
PHE A 238
TYR A 245
 None
 1.48A 6iblA-1smkA:
undetectable		 6iblA-1smkA:
25.34