SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1smq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 187
LEU A 315
SER A 246
ILE A 250
LEU A 262
 None
 1.11A 1drfA-1smqA:
undetectable		 1drfA-1smqA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		7 / 11 GLU A 176
HIS A 179
GLU A 239
SER A 246
PHE A 247
ILE A 269
GLU A 273
 None
 1.05A 1rnrA-1smqA:
26.6		 1rnrA-1smqA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		6 / 12 GLU A 176
HIS A 179
GLU A 239
PHE A 247
ILE A 269
GLU A 273
 None
 0.73A 1rnrB-1smqA:
26.6		 1rnrB-1smqA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		6 / 12 GLU A 176
HIS A 179
TYR A 183
GLU A 239
ILE A 269
GLU A 273
 None
 0.80A 1rnrB-1smqA:
26.6		 1rnrB-1smqA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 229
PRO A 291
ILE A 295
ILE A 299
 None
 0.84A 2q9rA-1smqA:
undetectable		 2q9rA-1smqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 331
ALA A 303
VAL A 334
GLY A 245
ILE A 269
 None
 0.89A 2v0zO-1smqA:
undetectable		 2v0zO-1smqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 265
ASN A 266
ILE A 269
TYR A 190
 None
 1.12A 2v57A-1smqA:
undetectable		 2v57A-1smqA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 265
ASN A 266
ILE A 269
TYR A 190
 None
 1.13A 2v57C-1smqA:
0.0		 2v57C-1smqA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 137
TYR A 183
SER A 144
GLY A 245
SER A 249
 None
 1.23A 3kk6B-1smqA:
0.0		 3kk6B-1smqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 247
PHE A 251
ASN A 359
THR A 277
 None
 1.12A 3t3sB-1smqA:
undetectable		 3t3sB-1smqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 284
VAL A 296
ILE A 299
ILE A 221
 None
 0.65A 3uqbA-1smqA:
undetectable		 3uqbA-1smqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 251
SER A 265
HIS A 179
TYR A 183
LEU A 138
 None
 1.23A 3vn2A-1smqA:
0.0		 3vn2A-1smqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 267
ASN A 266
GLU A 307
VAL A 334
 None
 1.11A 4ejwB-1smqA:
1.3		 4ejwB-1smqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 159
VAL A 160
GLY A 229
LEU A 287
 None
 1.07A 5syjA-1smqA:
undetectable		 5syjA-1smqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 244
ALA A 236
TRP A 216
TYR A 348
GLY A 240
 None
 1.35A 5tzoA-1smqA:
undetectable		 5tzoA-1smqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 338
LEU A 339
LEU A 232
GLY A 229
 None
 0.88A 6ce2A-1smqA:
undetectable		 6ce2A-1smqA:
14.21