SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1smr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)
1smr RENIN
(Mus
musculus)
3 / 3 THR A 295
PRO A 297
PRO A 294
None
0.81A 2d55C-1smrA:
undetectable
2d55C-1smrA:
7.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)
1smr RENIN
(Mus
musculus)
11 / 12 GLN A  13
ASP A  32
GLY A  34
SER A  35
TYR A  75
PRO A 111
PHE A 117
VAL A 120
ASP A 215
GLY A 217
SER A 219
None
0.41A 2v0zC-1smrA:
51.3
2v0zC-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)
1smr RENIN
(Mus
musculus)
6 / 12 VAL A 120
ASP A  32
GLY A  34
PRO A 111
PHE A 117
ASP A 215
None
1.48A 2v0zC-1smrA:
51.3
2v0zC-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)
1smr RENIN
(Mus
musculus)
7 / 12 VAL A 213
ASP A 215
GLY A 217
SER A 218
VAL A 300
ASP A  32
GLY A  34
None
0.58A 2v0zC-1smrA:
51.3
2v0zC-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)
1smr RENIN
(Mus
musculus)
10 / 12 GLN A  13
ASP A  32
GLY A  34
ALA A 115
PHE A 117
VAL A 120
ASP A 215
GLY A 217
SER A 219
ILE A 291
None
0.77A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)
1smr RENIN
(Mus
musculus)
6 / 12 VAL A 213
ASP A 215
GLY A 217
VAL A 300
ASP A  32
GLY A  34
None
0.43A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)
1smr RENIN
(Mus
musculus)
6 / 12 VAL A 213
ASP A 215
VAL A 300
ASP A  32
GLY A  34
ILE A  73
None
1.49A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_2
(RENIN)
1smr RENIN
(Mus
musculus)
4 / 8 SER A  35
TYR A  75
PRO A 111
THR A 295
None
0.60A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_2
(RENIN)
1smr RENIN
(Mus
musculus)
4 / 8 TYR A  14
SER A  35
TYR A  75
PRO A 111
None
0.46A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_2
(RENIN)
1smr RENIN
(Mus
musculus)
4 / 8 TYR A  14
TYR A  75
PRO A 111
LEU A 114
None
0.60A 2v0zO-1smrA:
50.8
2v0zO-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)
1smr RENIN
(Mus
musculus)
8 / 12 GLN A  13
ASP A  32
GLY A  34
PHE A 117
ASP A 215
SER A 219
SER A 222
HIS A 287
None
0.41A 3d91A-1smrA:
51.2
3d91A-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)
1smr RENIN
(Mus
musculus)
5 / 12 GLY A  34
PHE A 112
ASP A 215
SER A 222
HIS A 287
None
1.20A 3d91A-1smrA:
51.2
3d91A-1smrA:
69.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)
1smr RENIN
(Mus
musculus)
8 / 12 GLN A  13
ASP A  32
GLY A  34
VAL A 120
ASP A 215
SER A 219
SER A 222
HIS A 287
None
0.44A 3d91B-1smrA:
50.9
3d91B-1smrA:
69.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)
1smr RENIN
(Mus
musculus)
5 / 10 SER A  61
LEU A  38
ILE A  18
SER A  88
GLY A  19
None
1.39A 3ijxB-1smrA:
undetectable
3ijxD-1smrA:
undetectable
3ijxB-1smrA:
20.00
3ijxD-1smrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)
1smr RENIN
(Mus
musculus)
5 / 10 ILE A  18
SER A  88
GLY A  19
SER A  61
LEU A  38
None
1.41A 3ik6B-1smrA:
undetectable
3ik6E-1smrA:
undetectable
3ik6B-1smrA:
20.00
3ik6E-1smrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)
1smr RENIN
(Mus
musculus)
5 / 10 SER A  61
LEU A  38
ILE A  18
SER A  88
GLY A  19
None
1.41A 3iluB-1smrA:
undetectable
3iluE-1smrA:
undetectable
3iluB-1smrA:
20.00
3iluE-1smrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)
1smr RENIN
(Mus
musculus)
5 / 8 GLY A  34
SER A  35
ILE A  73
TYR A  75
ASP A 215
None
0.26A 3pwwA-1smrA:
37.7
3pwwA-1smrA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)
1smr RENIN
(Mus
musculus)
5 / 12 ILE A  30
ASP A  32
GLY A  34
GLY A  76
ASP A 215
None
0.57A 3q70A-1smrA:
10.8
3q70A-1smrA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)
1smr RENIN
(Mus
musculus)
6 / 12 ILE A  30
ASP A  32
GLY A  34
ILE A  73
GLY A  76
ASP A 215
None
0.53A 3tneA-1smrA:
35.8
3tneA-1smrA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)
1smr RENIN
(Mus
musculus)
5 / 12 ASP A  32
GLY A  34
ILE A  73
GLY A  76
ASP A 215
None
0.25A 3tneB-1smrA:
35.7
3tneB-1smrA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)
1smr RENIN
(Mus
musculus)
5 / 12 ILE A  30
ASP A  32
GLY A  34
GLY A  76
ASP A 215
None
0.43A 3tneB-1smrA:
35.7
3tneB-1smrA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
1smr RENIN
(Mus
musculus)
4 / 8 ASP A  87
ILE A  20
GLY A  21
VAL A  29
None
0.76A 4acbB-1smrA:
undetectable
4acbC-1smrA:
undetectable
4acbB-1smrA:
22.88
4acbC-1smrA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)
1smr RENIN
(Mus
musculus)
5 / 12 PHE A 305
ILE A 192
SER A 218
PHE A 322
GLY A 263
None
1.07A 4dm8B-1smrA:
undetectable
4dm8B-1smrA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.84A 4k8cA-1smrA:
undetectable
4k8cA-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.84A 4kahA-1smrA:
undetectable
4kahA-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.84A 4kahB-1smrA:
undetectable
4kahB-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.83A 4kanA-1smrA:
undetectable
4kanA-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.86A 4kanB-1smrA:
undetectable
4kanB-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.88A 4kbeA-1smrA:
undetectable
4kbeA-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.86A 4kbeB-1smrA:
undetectable
4kbeB-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.84A 4lbgA-1smrA:
undetectable
4lbgA-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
1smr RENIN
(Mus
musculus)
3 / 3 SER A  35
TYR A  75
PRO A 135
None
0.83A 4lbgB-1smrA:
undetectable
4lbgB-1smrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)
1smr RENIN
(Mus
musculus)
5 / 9 ILE A 221
ALA A 285
THR A 283
VAL A 247
ALA A 237
None
1.31A 4oqrA-1smrA:
undetectable
4oqrA-1smrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)
1smr RENIN
(Mus
musculus)
3 / 3 ASP A 215
ASP A  32
ASN A  37
None
0.71A 4q5mA-1smrA:
5.3
4q5mA-1smrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)
1smr RENIN
(Mus
musculus)
4 / 7 ILE A 258
LEU A 255
ALA A 234
ILE A 231
None
0.84A 4y03A-1smrA:
undetectable
4y03A-1smrA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1smr RENIN
(Mus
musculus)
5 / 12 GLY A  93
PHE A  71
ILE A  73
PHE A  31
THR A  95
None
1.13A 4zdyA-1smrA:
undetectable
4zdyA-1smrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)
1smr RENIN
(Mus
musculus)
5 / 10 ALA A 237
LEU A 205
LEU A 228
LEU A 230
THR A 203
None
1.32A 4zmeB-1smrA:
undetectable
4zmeB-1smrA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1smr RENIN
(Mus
musculus)
5 / 12 GLY A  93
PHE A  71
ILE A  73
PHE A  31
THR A  95
None
1.20A 5eslA-1smrA:
undetectable
5eslA-1smrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
1smr RENIN
(Mus
musculus)
4 / 5 ILE A  18
ILE A 140
HIS A 139
VAL A 136
None
0.89A 5jmnA-1smrA:
0.5
5jmnA-1smrA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)
1smr RENIN
(Mus
musculus)
5 / 12 GLY A 158
GLY A 217
ILE A  30
GLY A 163
GLY A 162
None
0.93A 5koxA-1smrA:
undetectable
5koxA-1smrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUR_A_STRA201_1
(AVIDIN)
1smr RENIN
(Mus
musculus)
5 / 10 MET A 232
TYR A 274
VAL A 197
PHE A 260
THR A 304
None
1.49A 5lurA-1smrA:
0.0
5lurA-1smrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)
1smr RENIN
(Mus
musculus)
4 / 5 PHE A 101
PHE A  71
LEU A  84
LEU A 121
None
1.28A 5veuH-1smrA:
undetectable
5veuH-1smrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)
1smr RENIN
(Mus
musculus)
4 / 6 GLN A  99
ASN A  37
VAL A 136
LEU A 141
None
1.25A 5xdhA-1smrA:
undetectable
5xdhC-1smrA:
undetectable
5xdhA-1smrA:
14.01
5xdhC-1smrA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1smr RENIN
(Mus
musculus)
3 / 3 ASN A  37
VAL A  96
HIS A 139
None
0.84A 6a5yD-1smrA:
undetectable
6a5yD-1smrA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
1smr RENIN
(Mus
musculus)
5 / 10 SER A  61
LEU A  38
ILE A  18
SER A  88
GLY A  19
None
1.30A 6dlzA-1smrA:
undetectable
6dlzD-1smrA:
undetectable
6dlzA-1smrA:
11.88
6dlzD-1smrA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
1smr RENIN
(Mus
musculus)
5 / 10 ILE A  18
SER A  88
GLY A  19
SER A  61
LEU A  38
None
1.31A 6dlzB-1smrA:
undetectable
6dlzC-1smrA:
undetectable
6dlzB-1smrA:
11.88
6dlzC-1smrA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
1smr RENIN
(Mus
musculus)
5 / 10 SER A  61
LEU A  38
ILE A  18
SER A  88
GLY A  19
None
1.27A 6dm0B-1smrA:
undetectable
6dm0C-1smrA:
undetectable
6dm0B-1smrA:
11.88
6dm0C-1smrA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
1smr RENIN
(Mus
musculus)
5 / 10 SER A  61
LEU A  38
ILE A  18
SER A  88
GLY A  19
None
1.32A 6dm1A-1smrA:
undetectable
6dm1D-1smrA:
undetectable
6dm1A-1smrA:
11.88
6dm1D-1smrA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
1smr RENIN
(Mus
musculus)
5 / 10 ILE A  18
SER A  88
GLY A  19
SER A  61
LEU A  38
None
1.32A 6dm1B-1smrA:
undetectable
6dm1C-1smrA:
undetectable
6dm1B-1smrA:
11.88
6dm1C-1smrA:
11.88