SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 8 ILE A 289
PHE A 101
ARG A 114
THR A 159
LEU A 158
 None
 1.46A 1v55N-1sngA:
undetectable
1v55W-1sngA:
undetectable		 1v55N-1sngA:
21.31
1v55W-1sngA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 10 SER A  35
LEU A 353
PHE A 354
LEU A  83
HIS A 301
 None
 1.30A 1y7iB-1sngA:
undetectable		 1y7iB-1sngA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 12 VAL A 221
LEU A 213
LEU A 219
PHE A 172
LEU A 305
 None
 1.09A 2aylA-1sngA:
0.0		 2aylA-1sngA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 5 LEU A 305
PHE A 259
VAL A 221
ALA A 166
 None
 1.22A 2cizA-1sngA:
0.0		 2cizA-1sngA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 12 LEU A 213
ALA A 166
VAL A 346
VAL A 223
VAL A 221
 None
 0.77A 2ieoB-1sngA:
undetectable		 2ieoB-1sngA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 6 LEU A 240
LEU A 243
ILE A 352
ARG A 347
 None
 1.15A 2rlfB-1sngA:
undetectable
2rlfC-1sngA:
undetectable		 2rlfB-1sngA:
5.42
2rlfC-1sngA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 6 HIS A  12
ALA A 237
THR A 241
PHE A   7
 None
 1.04A 2xfhA-1sngA:
undetectable		 2xfhA-1sngA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 11 THR A 212
MET A 210
LEU A 243
PRO A 235
LEU A  17
 None
 1.27A 3a51A-1sngA:
undetectable		 3a51A-1sngA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 12 LEU A   8
GLY A 350
ARG A   9
ALA A  40
ASP A  11
 None
None
None
CAF  A  41 ( 3.1A)
None
 1.09A 3gwwA-1sngA:
0.0		 3gwwA-1sngA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 8 ALA A 359
GLY A 356
ILE A  33
VAL A  27
 None
 0.70A 3nu9A-1sngA:
undetectable		 3nu9A-1sngA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		6 / 12 VAL A 296
ALA A 284
THR A  54
SER A 290
GLY A  49
GLY A  44
 None
None
None
None
None
CAF  A  41 ( 3.6A)
 1.33A 4rzvB-1sngA:
undetectable		 4rzvB-1sngA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		3 / 3 ALA A 116
TRP A  90
VAL A  91
 None
 0.43A 4w9nC-1sngA:
undetectable		 4w9nC-1sngA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 12 LEU A 286
GLY A  44
PRO A  68
LEU A  69
LEU A  58
 None
CAF  A  41 ( 3.6A)
None
None
None
 1.31A 4x61A-1sngA:
undetectable		 4x61A-1sngA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 5 ARG A 114
ARG A 126
GLY A 124
GLU A 123
 None
 1.15A 4z3oA-1sngA:
undetectable
4z3oB-1sngA:
undetectable		 4z3oA-1sngA:
20.51
4z3oB-1sngA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 6 ARG A 114
ARG A 126
GLY A 124
GLU A 123
 None
 0.97A 5btcA-1sngA:
0.0
5btcC-1sngA:
undetectable
5btcD-1sngA:
undetectable		 5btcA-1sngA:
24.76
5btcC-1sngA:
24.76
5btcD-1sngA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 6 ARG A 126
GLY A 124
GLU A 123
ARG A 114
 None
 0.91A 5btcA-1sngA:
0.0
5btcB-1sngA:
undetectable
5btcC-1sngA:
0.0		 5btcA-1sngA:
24.76
5btcB-1sngA:
20.98
5btcC-1sngA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		3 / 3 ARG A   9
THR A  64
ASP A  11
 None
 0.89A 5g5gA-1sngA:
undetectable
5g5gB-1sngA:
undetectable		 5g5gA-1sngA:
21.52
5g5gB-1sngA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		5 / 7 GLY A   6
LEU A 213
GLY A 350
LEU A   8
ILE A 344
 None
 1.37A 5vkqA-1sngA:
undetectable
5vkqB-1sngA:
undetectable		 5vkqA-1sngA:
12.34
5vkqB-1sngA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 5 LEU A   8
THR A 212
ARG A 245
ARG A 206
 None
 1.25A 6ew0B-1sngA:
0.0		 6ew0B-1sngA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 5 LEU A   8
THR A 212
ARG A 245
ARG A 206
 None
 1.25A 6ew0D-1sngA:
0.0		 6ew0D-1sngA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 5 LEU A   8
THR A 212
ARG A 245
ARG A 206
 None
 1.25A 6ew0H-1sngA:
0.0		 6ew0H-1sngA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1sng COG4826: SERINE
PROTEASE INHIBITOR
(Thermobifida
fusca) 		4 / 5 LEU A   8
THR A 212
ARG A 245
ARG A 206
 None
 1.25A 6ew0I-1sngA:
0.2		 6ew0I-1sngA:
12.36