SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1snn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A 123
LEU A 126
VAL A 130
 None
 0.28A 1mz9B-1snnA:
undetectable		 1mz9B-1snnA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 6 MET A 187
ALA A 193
GLU A  28
GLU A 185
 None
None
None
5RP  A 401 (-3.8A)
 1.44A 1qhyA-1snnA:
undetectable		 1qhyA-1snnA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A  32
ILE A 216
ILE A  17
LEU A  18
 None
 0.80A 3hegA-1snnA:
undetectable		 3hegA-1snnA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 213
ARG A 161
GLU A 166
LEU A 211
HIS A 164
 None
5RP  A 401 (-3.1A)
5RP  A 401 ( 4.5A)
None
ZN  A 402 ( 3.2A)
 1.29A 4azsA-1snnA:
undetectable		 4azsA-1snnA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 216
ALA A   7
LEU A  18
THR A 181
ILE A 183
 None
None
None
None
5RP  A 401 (-4.9A)
 0.96A 4ej1B-1snnA:
undetectable		 4ej1B-1snnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A   4
LEU A 171
LEU A 174
ILE A 217
 None
 0.81A 4lzrA-1snnA:
undetectable		 4lzrA-1snnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A  23
TYR A 210
TYR A  20
SER A  22
GLY A 213
 None
 1.36A 4mmcA-1snnA:
0.0		 4mmcA-1snnA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 216
ALA A   7
LEU A  18
THR A 181
ILE A 183
 None
None
None
None
5RP  A 401 (-4.9A)
 0.95A 4x5jA-1snnA:
undetectable		 4x5jA-1snnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A  23
TYR A 210
TYR A  20
SER A  22
GLY A 213
 None
 1.44A 4xpbA-1snnA:
undetectable		 4xpbA-1snnA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 161
HIS A 164
ARG A  25
 5RP  A 401 (-3.1A)
ZN  A 402 ( 3.2A)
5RP  A 401 (-2.9A)
 1.10A 5iaoC-1snnA:
undetectable		 5iaoC-1snnA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 161
HIS A 164
ARG A  25
 5RP  A 401 (-3.1A)
ZN  A 402 ( 3.2A)
5RP  A 401 (-2.9A)
 1.15A 5iaoF-1snnA:
undetectable		 5iaoF-1snnA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  70
ARG A 161
ALA A  57
 None
5RP  A 401 (-3.1A)
None
 0.69A 6ecfB-1snnA:
undetectable		 6ecfB-1snnA:
20.32