SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1snx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 ILE A 571
GLY A 574
PRO A 527
ASN A 592
None
0.92A 1oniG-1snxA:
undetectable
1oniI-1snxA:
undetectable
1oniG-1snxA:
19.92
1oniI-1snxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.79A 1v54C-1snxA:
1.3
1v54J-1snxA:
undetectable
1v54C-1snxA:
19.44
1v54J-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.80A 1v54P-1snxA:
1.3
1v54W-1snxA:
undetectable
1v54P-1snxA:
19.44
1v54W-1snxA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 ALA A 389
GLY A 441
CYH A 442
ASP A 445
LEU A 489
PHE A 501
None
0.45A 1xkkA-1snxA:
22.7
1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 ALA A 389
MET A 410
ASP A 445
LEU A 489
ASP A 500
PHE A 501
None
0.86A 1xkkA-1snxA:
22.7
1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 ALA A 389
MET A 410
GLY A 441
ASP A 445
LEU A 489
PHE A 501
None
0.77A 1xkkA-1snxA:
22.7
1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 MET A 410
ASP A 445
ARG A 448
LEU A 489
ASP A 500
PHE A 501
None
1.12A 1xkkA-1snxA:
22.7
1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 MET A 410
GLY A 441
ASP A 445
ARG A 448
LEU A 489
PHE A 501
None
1.07A 1xkkA-1snxA:
22.7
1xkkA-1snxA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.79A 2dyrC-1snxA:
0.9
2dyrJ-1snxA:
undetectable
2dyrC-1snxA:
19.44
2dyrJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.79A 2dyrP-1snxA:
1.3
2dyrW-1snxA:
undetectable
2dyrP-1snxA:
19.44
2dyrW-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.75A 2eikC-1snxA:
2.3
2eikJ-1snxA:
undetectable
2eikC-1snxA:
19.44
2eikJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.74A 2eikP-1snxA:
2.5
2eikW-1snxA:
0.0
2eikP-1snxA:
19.44
2eikW-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.79A 2eilC-1snxA:
1.4
2eilJ-1snxA:
undetectable
2eilC-1snxA:
19.44
2eilJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.76A 2eilP-1snxA:
undetectable
2eilW-1snxA:
undetectable
2eilP-1snxA:
19.44
2eilW-1snxA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 ALA A 389
LYS A 391
MET A 410
VAL A 419
PHE A 437
GLY A 441
LEU A 489
None
0.73A 2gqgA-1snxA:
31.3
2gqgA-1snxA:
41.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 ALA A 389
LYS A 391
LEU A 433
GLY A 441
ASP A 445
LEU A 489
None
0.63A 2itoA-1snxA:
29.8
2itoA-1snxA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
GLY A 441
ASP A 445
LEU A 489
ASP A 500
None
0.69A 2itzA-1snxA:
29.8
2itzA-1snxA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
3 / 3 ALA A 389
GLY A 441
SER A 499
None
0.46A 2ivuA-1snxA:
22.5
2ivuA-1snxA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 5 VAL A 409
LEU A 413
MET A 438
ARG A 481
None
0.83A 2oiqA-1snxA:
22.4
2oiqA-1snxA:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
3 / 3 ARG A 394
GLU A 395
GLN A 373
None
1.09A 2p16A-1snxA:
undetectable
2p16A-1snxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 12 ILE A 369
VAL A 377
ALA A 389
PHE A 435
MET A 438
GLY A 441
LEU A 489
ASP A 500
None
0.83A 2y7jA-1snxA:
23.8
2y7jA-1snxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 10 ILE A 369
VAL A 377
ALA A 389
PHE A 435
MET A 438
GLY A 441
LEU A 489
ASP A 500
None
0.83A 2y7jB-1snxA:
24.3
2y7jB-1snxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 10 ILE A 369
VAL A 377
ALA A 389
PHE A 435
MET A 438
GLY A 441
ASP A 445
LEU A 489
None
0.68A 2y7jC-1snxA:
24.0
2y7jC-1snxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 10 ILE A 369
VAL A 377
ALA A 389
PHE A 435
MET A 438
GLY A 441
ASP A 445
LEU A 489
None
0.65A 2y7jD-1snxA:
18.0
2y7jD-1snxA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 ALA A 389
MET A 438
GLY A 441
LEU A 489
None
0.31A 2yfxA-1snxA:
30.2
2yfxA-1snxA:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 ALA A 389
LYS A 391
MET A 410
VAL A 419
MET A 438
GLY A 441
LEU A 489
None
0.69A 2zvaA-1snxA:
21.9
2zvaA-1snxA:
41.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.74A 3ag2C-1snxA:
2.5
3ag2C-1snxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.76A 3ag2P-1snxA:
2.0
3ag2W-1snxA:
undetectable
3ag2P-1snxA:
19.44
3ag2W-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.81A 3ag4C-1snxA:
undetectable
3ag4J-1snxA:
undetectable
3ag4C-1snxA:
19.44
3ag4J-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.79A 3ag4P-1snxA:
2.5
3ag4W-1snxA:
undetectable
3ag4P-1snxA:
19.44
3ag4W-1snxA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 10 ALA A 389
LYS A 391
VAL A 419
MET A 438
GLY A 441
LEU A 489
None
0.58A 3aoxA-1snxA:
22.6
3aoxA-1snxA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.80A 3asnC-1snxA:
1.3
3asnJ-1snxA:
undetectable
3asnC-1snxA:
19.44
3asnJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.80A 3asoC-1snxA:
undetectable
3asoJ-1snxA:
undetectable
3asoC-1snxA:
19.44
3asoJ-1snxA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LEU A 421
GLY A 441
LEU A 489
ASP A 500
PHE A 501
None
0.70A 3bbtB-1snxA:
24.4
3bbtB-1snxA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 12 VAL A 377
ALA A 389
LYS A 391
LEU A 433
GLY A 441
LEU A 489
ASP A 500
PHE A 501
None
0.75A 3bbtD-1snxA:
24.8
3bbtD-1snxA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
5 / 12 ALA A 389
LEU A 418
GLY A 441
HIS A 480
LEU A 489
None
0.41A 3cs9A-1snxA:
22.5
3cs9A-1snxA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
5 / 9 VAL A 377
LYS A 391
VAL A 419
LEU A 489
VAL A 498
None
0.82A 3cs9B-1snxA:
31.2
3cs9B-1snxA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
5 / 12 ALA A 389
LEU A 418
PHE A 437
GLY A 441
HIS A 480
None
0.48A 3cs9D-1snxA:
22.6
3cs9D-1snxA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 ALA A 389
LYS A 391
MET A 410
VAL A 419
GLY A 441
LEU A 489
SER A 499
None
0.74A 3k54A-1snxA:
24.4
3k54A-1snxA:
53.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 11 ALA A 389
VAL A 419
PHE A 435
MET A 438
GLY A 441
LEU A 489
SER A 499
ASP A 500
None
0.80A 3miyA-1snxA:
27.7
3miyA-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 11 ILE A 369
ALA A 389
LYS A 391
PHE A 437
MET A 438
GLY A 441
LEU A 489
None
0.85A 3miyA-1snxA:
27.7
3miyA-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
9 / 11 ILE A 369
ALA A 389
VAL A 419
PHE A 435
PHE A 437
MET A 438
GLY A 441
LEU A 489
SER A 499
None
0.73A 3miyA-1snxA:
27.7
3miyA-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 9 ILE A 369
ALA A 389
LYS A 391
PHE A 435
PHE A 437
MET A 438
GLY A 441
LEU A 489
None
0.75A 3miyB-1snxA:
25.9
3miyB-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 9 ILE A 369
ALA A 389
PHE A 435
PHE A 437
MET A 438
GLY A 441
LEU A 489
SER A 499
None
0.67A 3miyB-1snxA:
25.9
3miyB-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
MET A 410
VAL A 419
GLY A 441
LEU A 489
None
0.68A 3octA-1snxA:
14.9
3octA-1snxA:
56.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
5 / 12 ILE A 369
VAL A 377
ALA A 389
LYS A 391
PHE A 501
None
0.58A 3og7A-1snxA:
29.3
3og7A-1snxA:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 ALA A 389
MET A 410
LEU A 418
VAL A 419
GLY A 441
HIS A 480
None
0.82A 3oxzA-1snxA:
22.4
3oxzA-1snxA:
40.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LYS A 391
LEU A 413
VAL A 478
LEU A 489
None
0.76A 3rgfA-1snxA:
20.8
3rgfA-1snxA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 9 ILE A 369
ALA A 389
VAL A 419
PHE A 435
PHE A 437
ASP A 500
None
0.94A 3ti1A-1snxA:
23.7
3ti1A-1snxA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 9 ILE A 369
ALA A 389
VAL A 419
PHE A 435
PHE A 437
LEU A 489
None
0.63A 3ti1A-1snxA:
23.7
3ti1A-1snxA:
27.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 ALA A 389
LYS A 391
VAL A 419
PHE A 437
MET A 438
GLY A 441
LEU A 489
None
0.42A 3ue4A-1snxA:
31.5
3ue4A-1snxA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 12 VAL A 377
ALA A 389
LYS A 391
LEU A 433
MET A 438
GLY A 441
ASP A 445
LEU A 489
None
0.72A 3ug2A-1snxA:
24.1
3ug2A-1snxA:
32.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 5 LYS A 391
VAL A 419
LEU A 489
ASP A 500
None
0.95A 3wzdA-1snxA:
24.4
3wzdA-1snxA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.83A 3x2qC-1snxA:
1.3
3x2qJ-1snxA:
undetectable
3x2qC-1snxA:
19.44
3x2qJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.85A 3x2qP-1snxA:
2.5
3x2qW-1snxA:
undetectable
3x2qP-1snxA:
19.44
3x2qW-1snxA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
5 / 11 ALA A 389
VAL A 419
PHE A 437
GLY A 441
LEU A 489
None
0.51A 4agdA-1snxA:
29.7
4agdA-1snxA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
GLY A 441
CYH A 442
LEU A 489
ASP A 500
None
0.81A 4hjoA-1snxA:
31.4
4hjoA-1snxA:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
MET A 438
GLY A 441
CYH A 442
LEU A 489
None
0.71A 4hjoA-1snxA:
31.4
4hjoA-1snxA:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 12 GLY A 370
VAL A 377
ALA A 389
LYS A 391
LEU A 433
GLY A 441
ASP A 445
LEU A 489
None
0.58A 4i22A-1snxA:
24.4
4i22A-1snxA:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 10 ILE A 369
ALA A 389
VAL A 419
GLY A 441
LEU A 489
SER A 499
ASP A 500
None
0.70A 4ks8A-1snxA:
24.2
4ks8A-1snxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 10 ILE A 369
ALA A 389
VAL A 419
PHE A 437
GLY A 441
LEU A 489
SER A 499
None
0.60A 4ks8A-1snxA:
24.2
4ks8A-1snxA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
VAL A 419
MET A 438
GLY A 441
LEU A 489
None
0.48A 4mxxB-1snxA:
23.7
4mxxB-1snxA:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 11 GLY A 370
VAL A 377
ALA A 389
LYS A 391
ASN A 487
LEU A 489
ASP A 500
None
0.91A 4o0sA-1snxA:
24.7
4o0sA-1snxA:
29.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 VAL A 377
LYS A 391
HIS A 480
LEU A 489
None
0.83A 4qrcA-1snxA:
29.7
4qrcA-1snxA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 11 ALA A 389
LYS A 391
MET A 438
GLY A 441
ASN A 487
LEU A 489
None
0.99A 4wa9A-1snxA:
27.8
4wa9A-1snxA:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 12 VAL A 377
ALA A 389
LYS A 391
MET A 410
VAL A 419
PHE A 437
GLY A 441
LEU A 489
None
0.58A 4xeyA-1snxA:
31.5
4xeyA-1snxA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
VAL A 419
PHE A 437
GLY A 441
LEU A 489
None
0.41A 4xeyB-1snxA:
13.5
4xeyB-1snxA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
3 / 5 GLY A 372
GLY A 370
GLU A 368
None
0.48A 4z2eA-1snxA:
3.7
4z2eD-1snxA:
undetectable
4z2eA-1snxA:
19.92
4z2eD-1snxA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
5 / 8 GLY A 370
VAL A 377
ALA A 389
MET A 438
GLY A 441
None
0.70A 4zauA-1snxA:
30.0
4zauA-1snxA:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 10 VAL A 377
ALA A 389
LYS A 391
MET A 438
GLY A 441
LEU A 489
None
0.47A 5aacA-1snxA:
15.3
5aacA-1snxA:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.89A 5b1aC-1snxA:
undetectable
5b1aJ-1snxA:
undetectable
5b1aC-1snxA:
19.44
5b1aJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.84A 5b1aP-1snxA:
2.5
5b1aW-1snxA:
undetectable
5b1aP-1snxA:
19.44
5b1aW-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.82A 5b1bP-1snxA:
1.3
5b1bW-1snxA:
undetectable
5b1bP-1snxA:
19.44
5b1bW-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.84A 5b3sC-1snxA:
undetectable
5b3sJ-1snxA:
undetectable
5b3sC-1snxA:
19.44
5b3sJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.86A 5b3sP-1snxA:
2.5
5b3sP-1snxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 8 LEU A 612
ILE A 590
PRO A 603
LEU A 608
None
0.88A 5g48A-1snxA:
undetectable
5g48A-1snxA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 ILE A 369
ALA A 389
LYS A 391
GLY A 441
LEU A 489
SER A 499
None
0.64A 5i9yA-1snxA:
24.8
5i9yA-1snxA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.85A 5iy5C-1snxA:
undetectable
5iy5J-1snxA:
undetectable
5iy5C-1snxA:
19.58
5iy5J-1snxA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 GLY A 370
VAL A 377
ALA A 389
VAL A 419
PHE A 435
LEU A 489
None
0.50A 5l2iA-1snxA:
8.4
5l2iA-1snxA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 GLY A 370
VAL A 377
ALA A 389
VAL A 419
PHE A 435
LEU A 489
None
0.86A 5l2tA-1snxA:
8.5
5l2tA-1snxA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
5 / 12 ALA A 389
LEU A 418
VAL A 419
HIS A 480
LEU A 489
None
0.64A 5mo4A-1snxA:
25.2
5mo4A-1snxA:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 VAL A 377
ALA A 389
GLY A 441
LEU A 489
SER A 499
PHE A 501
None
0.61A 5p9iA-1snxA:
25.8
5p9iA-1snxA:
54.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 LEU A 379
ALA A 389
VAL A 419
PHE A 437
GLY A 441
LEU A 489
None
0.53A 5te0A-1snxA:
23.2
5te0A-1snxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 LEU A 379
MET A 410
VAL A 419
PHE A 437
GLY A 441
LEU A 489
None
0.76A 5te0A-1snxA:
23.2
5te0A-1snxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 4 VAL A 377
LYS A 391
VAL A 419
ASN A 487
None
1.22A 5vc3A-1snxA:
23.9
5vc3A-1snxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 GLY A 370
VAL A 377
ALA A 389
LYS A 391
LEU A 433
CYH A 442
LEU A 489
None
0.77A 5yu9A-1snxA:
24.1
5yu9A-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 GLY A 370
VAL A 377
ALA A 389
LEU A 433
CYH A 442
ASP A 445
LEU A 489
None
0.73A 5yu9B-1snxA:
24.5
5yu9B-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LEU A 433
CYH A 442
ASP A 445
LEU A 489
ASP A 500
None
0.78A 5yu9B-1snxA:
24.5
5yu9B-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
LEU A 433
GLY A 441
ASP A 445
ASP A 500
None
0.93A 5yu9C-1snxA:
22.6
5yu9C-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
LYS A 391
LEU A 433
GLY A 441
CYH A 442
ASP A 445
None
0.83A 5yu9C-1snxA:
22.6
5yu9C-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
7 / 12 VAL A 377
ALA A 389
GLY A 441
CYH A 442
ASP A 445
LEU A 489
ASP A 500
None
0.63A 5yu9D-1snxA:
23.0
5yu9D-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
6 / 12 VAL A 377
ALA A 389
LYS A 391
CYH A 442
ASP A 445
ASP A 500
None
0.91A 5yu9D-1snxA:
23.0
5yu9D-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.84A 5z84C-1snxA:
undetectable
5z84J-1snxA:
undetectable
5z84C-1snxA:
19.44
5z84J-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.87A 5z85C-1snxA:
0.8
5z85J-1snxA:
undetectable
5z85C-1snxA:
19.44
5z85J-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.88A 5zcoC-1snxA:
2.1
5zcoJ-1snxA:
undetectable
5zcoC-1snxA:
19.44
5zcoJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.84A 5zcqC-1snxA:
2.4
5zcqJ-1snxA:
undetectable
5zcqC-1snxA:
19.44
5zcqJ-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 7 LEU A 418
GLN A 420
PHE A 501
LEU A 473
None
0.88A 5zcqP-1snxA:
1.4
5zcqW-1snxA:
undetectable
5zcqP-1snxA:
19.44
5zcqW-1snxA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
8 / 12 ILE A 369
VAL A 377
ALA A 389
LYS A 391
MET A 438
GLY A 441
LEU A 489
SER A 499
None
0.89A 6fnmA-1snxA:
24.9
6fnmA-1snxA:
38.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 5 VAL A 409
PHE A 437
MET A 438
GLY A 441
None
0.72A 6hd4A-1snxA:
29.5
6hd4A-1snxA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo
sapiens)
4 / 6 VAL A 409
PHE A 437
MET A 438
GLY A 441
None
0.76A 6hd4B-1snxA:
29.5
6hd4B-1snxA:
11.15