SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		3 / 3 GLN A  27
HIS A   1
PRO A  29
 None
 0.82A 1d8cA-1snyA:
undetectable		 1d8cA-1snyA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 9 CYH A  10
LEU A  16
THR A 220
ILE A 223
THR A   8
 None
 1.36A 1hzeA-1snyA:
0.0
1hzeB-1snyA:
0.0		 1hzeA-1snyA:
15.18
1hzeB-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 9 LEU A  84
LEU A 130
ILE A 150
THR A  34
ILE A   7
 None
 1.31A 1hzeA-1snyA:
0.0
1hzeB-1snyA:
0.0		 1hzeA-1snyA:
15.18
1hzeB-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 9 THR A   8
CYH A  10
LEU A  16
THR A 220
ILE A 223
 None
 1.36A 1hzeA-1snyA:
0.0
1hzeB-1snyA:
0.0		 1hzeA-1snyA:
15.18
1hzeB-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 9 THR A  34
ILE A   7
LEU A  84
LEU A 130
ILE A 150
 None
 1.31A 1hzeA-1snyA:
0.0
1hzeB-1snyA:
0.0		 1hzeA-1snyA:
15.18
1hzeB-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 10 CYH A  10
LEU A  16
THR A 220
ILE A 223
THR A   8
 None
 1.41A 1i18A-1snyA:
undetectable
1i18B-1snyA:
undetectable		 1i18A-1snyA:
15.18
1i18B-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 10 LEU A  84
LEU A 130
ILE A 150
THR A  34
ILE A   7
 None
 1.43A 1i18A-1snyA:
undetectable
1i18B-1snyA:
undetectable		 1i18A-1snyA:
15.18
1i18B-1snyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 11 LEU A 177
ILE A 149
LEU A 184
TYR A  68
THR A 114
 None
None
None
None
NAP  A 400 ( 4.0A)
 1.29A 1jomA-1snyA:
undetectable		 1jomA-1snyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 10 LEU A 177
ILE A 149
LEU A 184
TYR A  68
THR A 114
 None
None
None
None
NAP  A 400 ( 4.0A)
 1.33A 1tdrB-1snyA:
undetectable		 1tdrB-1snyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		4 / 8 VAL A 239
THR A 226
GLY A 221
THR A 220
 None
 0.86A 2a1hA-1snyA:
undetectable
2a1hB-1snyA:
undetectable		 2a1hA-1snyA:
20.55
2a1hB-1snyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		3 / 3 ASP A  66
TYR A  68
LYS A 124
 None
 1.12A 2othA-1snyA:
undetectable		 2othA-1snyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		4 / 7 ALA A  91
ASP A  61
LEU A  62
ARG A  63
 NAP  A 400 (-3.7A)
NAP  A 400 (-3.7A)
NAP  A 400 (-3.9A)
NAP  A 400 (-4.9A)
 0.82A 2uyqA-1snyA:
5.7		 2uyqA-1snyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 11 SER A 153
GLN A 222
SER A 197
LEU A 198
ASN A 240
 None
 0.91A 2xn5A-1snyA:
undetectable		 2xn5A-1snyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 177
ALA A 176
ILE A 149
LEU A 184
TYR A  68
 None
 0.82A 3dauA-1snyA:
undetectable		 3dauA-1snyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 12 ALA A 247
SER A 158
ILE A 155
LEU A 214
ASP A 242
 None
 1.08A 3k2hA-1snyA:
1.7		 3k2hA-1snyA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 12 ALA A 247
SER A 158
ILE A 155
LEU A 214
ASP A 242
 None
 1.10A 3k2hB-1snyA:
2.3		 3k2hB-1snyA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 177
ALA A 176
ILE A 149
LEU A 184
TYR A  68
 None
 0.87A 4pssA-1snyA:
undetectable		 4pssA-1snyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 177
ALA A 176
ILE A 149
LEU A 184
TYR A  68
 None
 0.89A 4psyA-1snyA:
undetectable		 4psyA-1snyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		4 / 8 LEU A  16
VAL A  19
ILE A  57
ALA A  42
 None
 0.71A 4qrcA-1snyA:
undetectable		 4qrcA-1snyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 10 SER A 153
GLN A 222
SER A 197
LEU A 198
ASN A 240
 None
 0.85A 4yiaA-1snyA:
0.0		 4yiaA-1snyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 12 LEU A  22
ASN A  54
LEU A  16
THR A  34
ILE A   7
 None
 1.28A 5b8hA-1snyA:
2.1
5b8hB-1snyA:
2.1		 5b8hA-1snyA:
25.67
5b8hB-1snyA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		3 / 3 ALA A  21
ASN A  24
LEU A  25
 None
 0.28A 5i1nB-1snyA:
undetectable		 5i1nB-1snyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		3 / 3 ALA A  21
ASN A  24
LEU A  25
 None
 0.38A 5i1oC-1snyA:
undetectable		 5i1oC-1snyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		3 / 3 ALA A  21
ASN A  24
LEU A  25
 None
 0.26A 5i1oA-1snyA:
undetectable		 5i1oA-1snyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		3 / 3 ALA A  21
ASN A  24
LEU A  25
 None
 0.32A 5i1pD-1snyA:
undetectable		 5i1pD-1snyA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		4 / 7 SER A 154
ILE A 155
LEU A 156
MET A 167
 NAP  A 400 (-3.7A)
None
None
None
 0.89A 5u4sA-1snyA:
24.9		 5u4sA-1snyA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 7 GLY A  17
LEU A  14
LEU A  87
ILE A 223
GLY A 221
 None
NAP  A 400 (-4.1A)
None
None
None
 1.40A 5vkqA-1snyA:
undetectable
5vkqB-1snyA:
undetectable		 5vkqA-1snyA:
9.83
5vkqB-1snyA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		4 / 6 ILE A   5
ILE A  60
LEU A  58
HIS A  56
 None
 1.04A 5vkqB-1snyA:
undetectable
5vkqC-1snyA:
undetectable		 5vkqB-1snyA:
9.83
5vkqC-1snyA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		4 / 6 ILE A   5
ILE A  60
LEU A  58
HIS A  56
 None
 1.02A 5vkqC-1snyA:
undetectable
5vkqD-1snyA:
undetectable		 5vkqC-1snyA:
9.83
5vkqD-1snyA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 10 GLY A 145
GLY A 143
LEU A 129
ILE A 193
ALA A 133
 None
 1.01A 5vm8B-1snyA:
2.1		 5vm8B-1snyA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 1sny SNIFFER CG10964-PA
(Drosophila
melanogaster) 		5 / 8 SER A 154
TYR A 170
HIS A 199
TRP A 202
MET A 207
 NAP  A 400 (-3.7A)
NAP  A 400 (-4.7A)
NAP  A 400 (-4.5A)
None
NAP  A 400 (-3.5A)
 0.59A 5wqpA-1snyA:
29.3		 5wqpA-1snyA:
29.21