SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1so8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		8 / 11 GLY A  17
ALA A  19
SER A  20
ASP A  41
LEU A  42
VAL A  65
ALA A  92
VAL A 120
 NA  A 302 (-3.6A)
None
NA  A 302 (-3.6A)
None
None
None
None
None
 0.42A 1uayA-1so8A:
23.8		 1uayA-1so8A:
57.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		8 / 10 GLY A  17
ALA A  19
SER A  20
ASP A  41
LEU A  42
VAL A  65
ALA A  92
VAL A 120
 NA  A 302 (-3.6A)
None
NA  A 302 (-3.6A)
None
None
None
None
None
 0.46A 1uayB-1so8A:
24.0		 1uayB-1so8A:
57.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 7 GLY A  46
GLY A  47
ALA A  19
PHE A  60
 None
 0.66A 2ha4B-1so8A:
4.1		 2ha4B-1so8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 5 LEU A  30
ILE A 151
ILE A 240
ALA A 239
 None
 0.69A 2i2zA-1so8A:
0.6		 2i2zA-1so8A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 4 LEU A  30
ILE A 151
ILE A 240
ALA A 239
 None
 0.70A 2i30A-1so8A:
undetectable		 2i30A-1so8A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		5 / 12 GLY A  17
ALA A  19
ALA A  25
LEU A  42
VAL A  65
 NA  A 302 (-3.6A)
None
None
None
None
 0.89A 2nyuA-1so8A:
10.0		 2nyuA-1so8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		5 / 12 GLY A  17
ALA A  19
LEU A  42
VAL A  65
THR A  66
 NA  A 302 (-3.6A)
None
None
None
None
 0.51A 2nyuB-1so8A:
10.0		 2nyuB-1so8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		5 / 10 THR A  16
VAL A 128
VAL A 132
VAL A  38
ILE A  15
 None
 1.48A 2qboA-1so8A:
0.0		 2qboA-1so8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 4 LYS A 229
LEU A 253
ALA A 234
LEU A 236
 None
 1.50A 2roxA-1so8A:
undetectable		 2roxA-1so8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		5 / 12 THR A  66
SER A 155
THR A 195
ASN A 152
ALA A  92
 None
CL  A 303 (-4.8A)
None
None
None
 1.28A 2x2iC-1so8A:
undetectable		 2x2iC-1so8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 4 LEU A  39
ASP A  86
VAL A  89
THR A  26
 None
 1.16A 3cyxB-1so8A:
undetectable		 3cyxB-1so8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 7 THR A 179
ILE A 182
ILE A 129
THR A 195
 None
 0.87A 3deuA-1so8A:
undetectable		 3deuA-1so8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		6 / 11 GLY A  17
GLY A  18
THR A  26
ASP A  41
LEU A  42
ASP A  64
 NA  A 302 (-3.6A)
None
None
None
None
None
 1.32A 4pghA-1so8A:
6.6		 4pghA-1so8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		5 / 12 GLY A  17
THR A  26
ASP A  41
LEU A  42
ASP A  64
 NA  A 302 (-3.6A)
None
None
None
None
 1.42A 4pghB-1so8A:
6.8		 4pghB-1so8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		3 / 3 ASP A 142
ARG A 192
PRO A 244
 None
 0.87A 4wanC-1so8A:
undetectable		 4wanC-1so8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		3 / 3 LEU A  75
VAL A  12
ASP A  86
 None
 0.67A 4y8wC-1so8A:
undetectable		 4y8wC-1so8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		5 / 8 LEU A  24
GLY A  21
ALA A  27
LEU A  54
GLY A  47
 None
NA  A 302 ( 4.3A)
None
None
None
 0.80A 4zauA-1so8A:
undetectable		 4zauA-1so8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 4 VAL A  87
ILE A  15
ASN A 152
VAL A 128
 None
 1.22A 5ajqA-1so8A:
undetectable		 5ajqA-1so8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		5 / 12 ALA A  27
GLY A  17
GLY A  23
GLY A  21
LEU A  40
 None
NA  A 302 (-3.6A)
NA  A 302 ( 4.5A)
NA  A 302 ( 4.3A)
None
 0.83A 5c0oH-1so8A:
6.9		 5c0oH-1so8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens) 		4 / 5 ILE A 189
GLN A 138
ARG A 147
GLU A 135
 None
 1.33A 5fseC-1so8A:
3.1		 5fseC-1so8A:
19.16