SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1soi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 8 LEU A  72
ALA A 100
GLY A  17
ILE A  47
VAL A  74
 None
 1.16A 1d4sB-1soiA:
undetectable		 1d4sB-1soiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 4 ALA A 128
ARG A 124
GLN A 129
GLU A 125
 None
 1.20A 1lqtB-1soiA:
undetectable		 1lqtB-1soiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 4 ALA A 128
ARG A 124
GLN A 129
GLU A 125
 None
 1.22A 1lquB-1soiA:
undetectable		 1lquB-1soiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 7 ALA A  62
ALA A  66
THR A  70
LEU A  28
 None
 0.88A 2wx2A-1soiA:
undetectable		 2wx2A-1soiA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 8 ALA A  62
ALA A  66
THR A  70
LEU A  28
 None
 0.93A 2wx2B-1soiA:
undetectable		 2wx2B-1soiA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 8 ALA A  62
ALA A  66
THR A  70
LEU A  28
 None
 0.88A 3khmA-1soiA:
undetectable		 3khmA-1soiA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 8 ALA A  62
ALA A  66
THR A  70
LEU A  28
 None
 0.86A 3l4dA-1soiA:
undetectable		 3l4dA-1soiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 10 ARG A 150
ALA A 146
LEU A 149
GLY A 153
ALA A 119
 SM  A 302 (-3.5A)
None
None
None
None
 1.36A 4fe1A-1soiA:
undetectable
4fe1J-1soiA:
0.0		 4fe1A-1soiA:
11.94
4fe1J-1soiA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A 128
ALA A  62
ALA A  66
THR A  70
LEU A  28
 None
 1.32A 6aycA-1soiA:
undetectable		 6aycA-1soiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1soi MUTT/NUDIX FAMILY
PROTEIN
(Deinococcus
radiodurans) 		3 / 3 ARG A  86
PHE A  87
GLY A  90
 SM  A 303 ( 4.7A)
None
SM  A 303 (-4.8A)
 0.76A 6fgdA-1soiA:
undetectable		 6fgdA-1soiA:
18.61