SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		5 / 10 LEU A  72
LEU A  70
LEU A  57
GLU A  54
LEU A  60
 None
 1.36A 1ie4A-1souA:
undetectable
1ie4C-1souA:
undetectable		 1ie4A-1souA:
21.84
1ie4C-1souA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 160
PRO A 161
LEU A 129
 None
 0.47A 2po5B-1souA:
undetectable		 2po5B-1souA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 160
PRO A 161
LEU A 129
 None
 0.44A 2po7B-1souA:
undetectable		 2po7B-1souA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 129
TRP A 165
TYR A 127
 None
 0.96A 3aicA-1souA:
undetectable		 3aicA-1souA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 129
TRP A 165
TYR A 127
 None
 0.95A 3aicB-1souA:
undetectable		 3aicB-1souA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 129
TRP A 165
TYR A 127
 None
 0.93A 3aicE-1souA:
undetectable		 3aicE-1souA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 129
TRP A 165
TYR A 127
 None
 0.92A 3aicF-1souA:
undetectable		 3aicF-1souA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 129
TRP A 165
TYR A 127
 None
 0.96A 3aicG-1souA:
undetectable		 3aicG-1souA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A 129
TRP A 165
TYR A 127
 None
 0.92A 3aicH-1souA:
undetectable		 3aicH-1souA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 TYR A  48
GLY A  97
ALA A  95
ILE A  80
 None
 0.84A 3jusA-1souA:
undetectable		 3jusA-1souA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 TYR A  48
GLY A  97
ALA A  95
ILE A  80
 None
 0.84A 3jusA-1souA:
undetectable		 3jusA-1souA:
19.74