SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 HIS A  78
TYR A  81
ALA A 115
GLU A 117
 None
 0.88A 1dmaB-1sp3A:
undetectable		 1dmaB-1sp3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		5 / 12 GLU A 117
LEU A  99
TYR A 108
GLY A  80
GLY A 116
 None
 1.27A 1httD-1sp3A:
undetectable		 1httD-1sp3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 SER A  16
THR A  94
PHE A  88
GLY A  82
 None
 1.10A 1icuA-1sp3A:
undetectable
1icuB-1sp3A:
undetectable		 1icuA-1sp3A:
19.38
1icuB-1sp3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 PHE A  88
GLY A  82
SER A  16
THR A  94
 None
 1.03A 1icuA-1sp3A:
undetectable
1icuB-1sp3A:
undetectable		 1icuA-1sp3A:
19.38
1icuB-1sp3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 SER A  16
THR A  94
PHE A  88
GLY A  82
 None
 1.02A 1icuC-1sp3A:
undetectable
1icuD-1sp3A:
undetectable		 1icuC-1sp3A:
19.38
1icuD-1sp3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 5 PHE A  88
GLY A  82
SER A  16
THR A  94
 None
 1.10A 1icuC-1sp3A:
undetectable
1icuD-1sp3A:
undetectable		 1icuC-1sp3A:
19.38
1icuD-1sp3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 5 PHE A  88
GLY A  82
SER A  16
THR A  94
 None
 1.09A 1icvA-1sp3A:
undetectable
1icvB-1sp3A:
undetectable		 1icvA-1sp3A:
19.38
1icvB-1sp3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 SER A  16
THR A  94
PHE A  88
GLY A  82
 None
 1.16A 1kqbA-1sp3A:
undetectable
1kqbB-1sp3A:
undetectable		 1kqbA-1sp3A:
18.86
1kqbB-1sp3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 SER A  16
THR A  94
PHE A  88
GLY A  82
 None
 1.13A 1kqbC-1sp3A:
undetectable
1kqbD-1sp3A:
undetectable		 1kqbC-1sp3A:
18.86
1kqbD-1sp3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 PHE A  88
GLY A  82
SER A  16
THR A  94
 None
 1.17A 1kqbC-1sp3A:
undetectable
1kqbD-1sp3A:
undetectable		 1kqbC-1sp3A:
18.86
1kqbD-1sp3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 TYR A 314
GLY A 317
ASP A 321
ASN A 292
 None
 1.08A 2g70A-1sp3A:
undetectable		 2g70A-1sp3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 TYR A 314
GLY A 317
ASP A 321
ASN A 292
 None
 1.08A 2g70B-1sp3A:
undetectable		 2g70B-1sp3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 TYR A 314
GLY A 317
ASP A 321
ASN A 292
 None
 1.07A 2g72A-1sp3A:
undetectable		 2g72A-1sp3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 TYR A 314
GLY A 317
ASP A 321
ASN A 292
 None
 1.08A 2g72B-1sp3A:
undetectable		 2g72B-1sp3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		5 / 9 GLY A 369
ILE A 337
THR A 392
VAL A  65
ILE A  60
 None
 1.24A 2nnhB-1sp3A:
undetectable		 2nnhB-1sp3A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		5 / 12 VAL A 170
PRO A 328
ASP A 169
CYH A 209
TYR A 327
 HEM  A 806 ( 4.5A)
None
None
HEM  A 806 (-1.9A)
None
 1.41A 3p6gA-1sp3A:
undetectable		 3p6gA-1sp3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		5 / 12 ASP A 205
ASP A 156
ILE A 237
ARG A 397
HIS A 154
 HEM  A 805 (-3.8A)
None
None
HEM  A 805 ( 3.9A)
HEM  A 802 (-4.1A)
 1.48A 3phaC-1sp3A:
undetectable		 3phaC-1sp3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		5 / 12 ASP A 205
ASP A 156
ILE A 237
ARG A 397
HIS A 154
 HEM  A 805 (-3.8A)
None
None
HEM  A 805 ( 3.9A)
HEM  A 802 (-4.1A)
 1.43A 3phaD-1sp3A:
undetectable		 3phaD-1sp3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 6 HIS A 332
MET A 394
THR A 313
ARG A  54
 None
HEM  A 802 ( 4.9A)
None
HEM  A 802 ( 4.8A)
 1.15A 3thrB-1sp3A:
undetectable		 3thrB-1sp3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		3 / 3 ASP A 339
GLU A 386
GLY A 385
 None
 0.50A 3w9tA-1sp3A:
undetectable		 3w9tA-1sp3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 HIS A  78
TYR A  81
ALA A 115
GLU A 117
 None
 0.80A 4hyfA-1sp3A:
undetectable		 4hyfA-1sp3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 8 HIS A  78
TYR A  81
ALA A 115
GLU A 117
 None
 0.82A 4hyfB-1sp3A:
undetectable		 4hyfB-1sp3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 8 HIS A  78
TYR A  81
ALA A 115
GLU A 117
 None
 0.80A 4hyfC-1sp3A:
undetectable		 4hyfC-1sp3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		3 / 3 SER A 159
TYR A 145
PRO A 164
 None
 0.96A 4lbgA-1sp3A:
undetectable		 4lbgA-1sp3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		3 / 3 SER A 159
TYR A 145
PRO A 164
 None
 0.97A 4lbgB-1sp3A:
undetectable		 4lbgB-1sp3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 7 ASP A  92
GLY A  80
THR A  94
TRP A  39
 None
 1.04A 4zxiA-1sp3A:
undetectable		 4zxiA-1sp3A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 4 ASP A 137
GLY A 106
ASP A 103
ASP A  97
 None
 1.17A 5e72A-1sp3A:
undetectable		 5e72A-1sp3A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		4 / 5 TYR A 108
LYS A 110
GLU A 117
GLY A  15
 None
 1.36A 5jhdJ-1sp3A:
0.0		 5jhdJ-1sp3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		5 / 10 ARG A  50
ASP A 339
ASN A 343
TYR A 383
ALA A 366
 None
 1.41A 5x66D-1sp3A:
undetectable		 5x66D-1sp3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1sp3 CYTOCHROME C,
PUTATIVE
(Shewanella
oneidensis) 		5 / 12 TYR A 387
PHE A 389
ILE A 337
GLY A 256
ALA A 255
 None
 1.04A 5zwrA-1sp3A:
undetectable		 5zwrA-1sp3A:
21.19